The Evaluation of the Role of Androgens in Hirsutism and the Use of a New Anti-androgen “Cyproterone Acetate” for Therapy

Ismail, A. A. A.; Davidson, D. W.; Souka, A. R.; Barnes, Erin; Irvine, W. J.; Kilimnik, H.; Vanderbeeken, Y.E.

doi:10.1210/jcem-39-1-81

Cited by 63 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Individual cases, however, had no clinical benefit, in spite of the depression of plasma T, as observed by other investigators (4, 14,20). It is likely that the hair growth, once stimulated, continues to be maintained even by small amounts of androgens.…”

Section: Discussionmentioning

confidence: 64%

Simultaneous Estimation of Four Plasma Androgens Before and After Dynamic Tests in Women with Hirsutism: Correlation with Long-Term Therapy

Sciarra¹,

Toscano²,

Concolino³

et al. 1976

Horm Res

View full text Add to dashboard Cite

Concentrations of testosterone, △⁴-androstenedione, dihydrotestosterone and Δ⁵-androstenediol were measured in 12 patients affected by hirsutism associated with menstrual disorders. Testosterone was elevated in 9 cases, in whom high levels of Δ⁴-androstenedione and dihydrotestosterone were found, and normal in 3 cases, 2 of which presented high values of dihydrotestosterone and one high levels of Δ⁵-androstenediol. In some hirsute females therefore, other androgens, such as dihydrotestosterone and Δ⁵-androstenediol, play a role in the pathogenesis of hirsutism. Dexamethasone and estrogen progestin combinations were administered for dynamic tests, and results in most cases provided useful information in the selection of suitable long-term therapy.

show abstract

Section: Discussionmentioning

confidence: 64%

Simultaneous Estimation of Four Plasma Androgens Before and After Dynamic Tests in Women with Hirsutism: Correlation with Long-Term Therapy

Sciarra¹,

Toscano²,

Concolino³

et al. 1976

Horm Res

View full text Add to dashboard Cite

show abstract

“…Man agement may include local treatment or sys temic therapy with combined oral contracep tives [1], spironolactone [2] or cyproterone acetate (CA) [3,4], The results of treatment with such agents are difficult to assess objec tively and are usually reported in terms of subjective patient improvement. In 1978, Burgess and Edwards [5] described a photo graphic technique for assessment of hair growth.…”

Section: Introductionmentioning

confidence: 99%

Objective Assessment of Treatment Response in Hirsutism

et al. 1985

View full text Add to dashboard Cite

A simple photographic technique was used to assess the objective response of hirsute women to treatment with cyproterone acetate (CA). The skin in front of the left ear was shaved and photographs taken immediately and after 1 week, and hair growth per week estimated by averaging the length of 20 hairs in the magnified photographs. The precision, repeatability and patient acceptance of the method were found to be satisfactory. Basal hair growth rates were 2.28 ± 0.4 mm/week (mean ± SD, n = 34) and showed a significant correlation with hirsutism scores derived from a standard physician-rated scale. During therapy with CA the mean ( ± SD) improvement in hair growth rate was 19 ± 13%, whereas physician-rated hirsutism scores improved by 33 ± 20%. The reduction in hair growth rate showed no significant correlation with improvement assessed using subjective rating by either physician or patient. The greater improvement in physician-rated scores compared with hair growth rate assessment suggests that hair shaft width, colour and other factors may be as important as hair length when assessing treatment response.

show abstract

“…The antiandrogen cyproteroneacetate (CA; 1,2 a-methylene-6-chloro-A4,6-pregnadiene-17 a-ol-3,20-dione-acetate), synthesized by Wiechert et al [1969], became available and appears to be effective [Ismail et al, 1974;Braendle et al, 1974;Barnes et al, 1975;Laschinsky et al, 1976]. CA being chemically related to progesterone and testosterone, it competes with androgenic steroids for binding to the receptors in target organs such as the gonads and mammary glands [Neumann et al, 1970] and especially the pilosebaceous organs of the skin [Neumann and Eiger, 1966], as has been dem onstrated in animal experiments [Neumann and Eiger, 1966].…”

Section: Introductionmentioning

confidence: 99%

“…CA has an antiandrogenic, progestative and antigonadotropic action. Various authors [Ismail et al, 1974;Braendle et al, 1974;Barnes et al, 1975;Laschinsky et al, 1976;Hammerstein and Cupceaucu, 1969;Leo-Roszberg et al, 1971;Bettendorf, 1968;Lebeau and Vokaer, 1972;Winkler, 1968] report favorable results of treatment of idiopathic hirsutism with this medication, using the reverse sequential method, as originally described by Hammerstein and Cupceaucu [1969].…”

Section: Introductionmentioning

confidence: 99%

“…The following parameters have been used by several authors for evalua tion of the results of this treatment: (1) photographs and subjective clinical findings [Hammerstein and Cupceaucu, 1969]; (2) photographs, quantification of production of sebaceous glands and hair state investigation [Leo-Roszberg et al, 1971]; (3) frequency of shaving, growth rate of hair and number of growing follicles [Ismail et al, 1974;Zaun, 1972], and (4) semi-quantitative scores for regional hair growth according to Ferriman and Galhvay [1961].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Cyproterone Acetate Orally on Hair Density and Diameter and Endocrine Factors in Women with Idiopathic Hirsutism

Peereboom-Wynia¹,

Boekhorst²

1980

Dermatology

View full text Add to dashboard Cite

The effect of oral cyproterone acetate on hair density and diameter was studied in a clinically homogeneous group of 11 women with idiopathic hirsutism. Therapy was continued for 12 cycles of treatment. Hair density and mean hair diameter on the chin and left upper leg were measured before, immediately after and 3 months after therapy. Generally, the effect of treatment consisted of a quantitative reduction of both parameters, but the effect was not permanent after termination of therapy. Concurrently, the possible influence on plasma androgen was studied. No significant differences were found between the concentrations of plasma testosterone, dehydroepiandrosterone and androstenedione before and after treatment.

show abstract

The Evaluation of the Role of Androgens in Hirsutism and the Use of a New Anti-androgen “Cyproterone Acetate” for Therapy

Cited by 63 publications

References 0 publications

Simultaneous Estimation of Four Plasma Androgens Before and After Dynamic Tests in Women with Hirsutism: Correlation with Long-Term Therapy

Simultaneous Estimation of Four Plasma Androgens Before and After Dynamic Tests in Women with Hirsutism: Correlation with Long-Term Therapy

Objective Assessment of Treatment Response in Hirsutism

Effect of Cyproterone Acetate Orally on Hair Density and Diameter and Endocrine Factors in Women with Idiopathic Hirsutism

Contact Info

Product

Resources

About