The evaluation of superoxide dismutase activity, neutrophil function, and metabolic profile in cows with retained placenta

Yazlık, Murat Onur; Çolakoğlu, Hatice Esra; Pekcan, Mert; Kaya, Ufuk; Kaçar, Cihan; Vural, Mehmet Rıfat; Kurt, Serdal; Baş, Ahmet Yağmur; Küplülü, Şükrü

doi:10.1016/j.theriogenology.2019.01.020

Cited by 12 publications

(13 citation statements)

References 39 publications

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“…Moreover, it has been well-known that there is a close interaction between oxidation state and inflammation in the process of expelling fetal membranes ( 25 , 26 , 38 ). Oxidative stress increases the risk of placental retention ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

“…The separation and expulsion of the placenta from the maternal uterus is a coordinated, regulated multi-system and multi-factor process. It has been demonstrated that the immune response plays a vital role in the process of separation and discharge of the placenta (16,26,27). During the perinatal period, Th1 cells are gradually derived from Th2 cells and secrete proinflammatory cytokines to initiate an inflammatory response, which induces apoptosis of trophoblast cells and endometrial epithelial cells and promotes placental separation (27,(35)(36)(37).…”

Section: Discussionmentioning

confidence: 99%

“…A growing body of evidence supports the utilization of alterations in biochemical profiles, antioxidant ability, cytokines, and hormones as biological indicators of RP ( 3 , 25 , 26 ). It has also recognized that several reproductive hormones and Th1 and Th2 cells participate in the process of separation and discharge of the placenta ( 16 , 26 , 27 ). Besides, oxidative stress and alterations in biochemical profiles as reasons or results of RP have been extensively attended.…”

Section: Introductionmentioning

confidence: 99%

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Plasma Metabolomics Reveals Pathogenesis of Retained Placenta in Dairy Cows

Zhao

et al. 2021

Front. Vet. Sci.

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The complex etiology and pathogenesis of retained placenta (RP) bring huge challenges for researchers and clinical veterinarians in investigating the pathogenesis and treatment schedule. This study aims to investigate the pathogenesis of RP in dairy cows by plasma metabolomics. As subjects, 10 dairy cows with RP and 10 healthy dairy cows were enrolled according to strict enrollment criteria. Imbalanced antioxidant capacity, reduced Th1/Th2 cytokine ratio, and deregulation of total bilirubin (T-bil), alkaline phosphatase (ALP), and reproductive hormones were shown in dairy cows with RP by detecting biochemical indicators, oxidation and antioxidant markers, and cytokines in serum. Plasma metabolites were detected and analyzed by a liquid chromatography–mass spectrometry (LC–MS) system coupled with multivariate statistical analysis software. A total of 23 potential biomarkers were uncovered in the plasma of dairy cows with RP. The metabolic pathways involved in these potential biomarkers are interconnected, and the conversion, utilization, and excretion of nitrogen were disturbed in dairy cows with RP. Moreover, these potential biomarkers are involved in the regulation of antioxidant capacity, inflammation, and autocrine or paracrine hormone. All of these findings suggest that an imbalance of these potential biomarkers might be responsible for the imbalanced antioxidant capacity, reduced Th1/Th2 cytokine ratio, and deregulation of reproductive hormones in dairy cows with RP. The regulation of metabolic pathways involved in these potential biomarkers represents a promising therapeutic strategy for RP.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Plasma Metabolomics Reveals Pathogenesis of Retained Placenta in Dairy Cows

Zhao

et al. 2021

Front. Vet. Sci.

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“…Except for total antioxidant activity (TAC) and vitamin A, the contents of oxidative and antioxidative blood constituents did not differ between cows with and without RP. Moreover, the recent study carried out by Yazlık et al (2019) concluded that high SOD antepartum in cows was an indicator of a higher incidence of RP occurrence. This indicates that pre-partum oxidative metabolism and metabolic status are associated with the occurrence of RP in cows, and the periparturient metabolic oxidative markers might be used as screening biomarkers for these cows.…”

Section: Metabolomics Includes Biomarkers Of Inflammationmentioning

confidence: 97%

Latest update on predictive indicators, risk factors and ‘Omic’ technologies research of retained placenta in dairy cattle – A review

Amin

Hussein

2022

Reprod Domestic Animals

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Retained placenta is a pathological condition defined as failure to expel foetal membranes within 12–24 h after parturition. It instigates important financial losses to the dairy industry causing considerable economic loss. It is a multifactorial disorder. Although different hypotheses have been proposed, contradictory results and no single factor explains the development of the disease. This indicates that there are overall significant gaps in our knowledge about the various factors affecting the aetiopathology and pathobiology of the retained placenta. Thus, it will be of great interest to investigate the potential contributing factors that influence the occurrence of RP which provide us with the mechanisms to avoid the occurrence of the disease. In addition, different predictive indicators of RP should be a part of our research, thus providing the essential procedures applied to deal with the disease and the development of novel therapeutic and prophylactic strategies in its management. Furthermore, lately, the molecular role takes attention to understanding its effect in the occurrence of the disease. Such information might help dairy scientists in the future to design better management and preventive practices for RP in dairy cows.

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“…Therefore, it can increase susceptibility to diseases (Lykkesfeldt and Svendsen, 2007). Oxidative stress may be associated with uterine infections in the periparturient period (Yazlık et al, 2019;Mikulková et al, 2020). On the other hand, it is known that cytokines such as TNF-α are closely linked to the inflammation caused by the infection.…”

Section: Introductionmentioning

confidence: 99%

Monitoring of oxidative stress and TNF-α status during the healing process in hair goats with metritis

Kurt

Eşki

MİS

2022

Turkish Journal of Veterinary Research

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Objective: This study aimed to monitor oxidative stress parameters including total antioxidant status (TAS) and total oxidant status (TOS), and tumor necrosis factor-alpha (TNF-α) level during the healing process in hair goats with metritis. Materials and Methods:This study was carried out on a total of 25 hair goats with metritis (n=10; Group 1) and healthy (n=15; Group 2). The beginning of the study was accepted as day 0. In both Group 1 and Group 2, blood samples were collected on days 0 (first measurement day), 14 (second measurement day) and 28 (third measurement day) of the study for TAS, TOS and TNF-α analyzes. In addition, oxidative stress index (OSI) was calculated using TAS and TOS values.Results: It was found that TAS level decreased in Group 1 compared to Group 2 at the first measurement day (p<0.05). However, TOS, OSI and TNF-α levels increased in Group 1 compared to Group 2 (p<0.01). At the second measurement day, TOS and OSI values were higher in Group 1 than Group 2 (p<0.05). Conclusion:In conclusion, the antioxidant system weakened, oxidative stress and TNF-α levels increased in animals with metritis compared to healthy animals. However, at the third measurement time, all parameters became similar between groups.

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The evaluation of superoxide dismutase activity, neutrophil function, and metabolic profile in cows with retained placenta

Cited by 12 publications

References 39 publications

Plasma Metabolomics Reveals Pathogenesis of Retained Placenta in Dairy Cows

Plasma Metabolomics Reveals Pathogenesis of Retained Placenta in Dairy Cows

Latest update on predictive indicators, risk factors and ‘Omic’ technologies research of retained placenta in dairy cattle – A review

Monitoring of oxidative stress and TNF-α status during the healing process in hair goats with metritis

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