The evaluation of serum vitamin B12, folic acid and hemoglobin levels in patients with recurrent minor aphthous stomatitis

Aynali, Giray; Özkan, Mustafa; Aynalı, Ayşe; Ceyhan, Betül Mermi; Armağan, Hakan; Yariktaş, Murat; Doğan, Mustafa

doi:10.5606/kbbihtisas.2013.64426

Cited by 8 publications

(6 citation statements)

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“…However, in our study, in serum iron, ferritin, vitamin B12 and folic acid and hemogram tests of the patients with RAS, the average values were found to be within the normal limits; in comparisons of individuals who did not have RAS, no statistically significant results were obtained (Table 1). In the literature, there are in similar results to those reported by our study, but the cause of these different outcomes is not clear (15)(16)(17). It is known that the RAS prevalence is higher in women and the young than in men (10).…”

Section: Recurrent Aphthous Stomatitissupporting

confidence: 81%

Investigation of Behçet's Disease and Recurrent Aphthous Stomatitis Frequency: The Highest Prevalence in Turkey

et al. 2016

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Methods: Overall, 85 separate exemplification groups were formed to reflect the population density, and the demographic data of the region they represent. In the first stage, the individuals, who were selected in random order, were invited to a Family Physician Unit at a certain date and time. The dermatological examinations of the volunteering individuals were performed by only 3 dermatology specialists. In the second stage, those individuals who had symptoms of BD were invited to our hospital, and the Pathergy Test and eye examinations were performed. Results:The annual prevalence of RAS was determined as 10.84%. The annual prevalence was determined to be higher in women than in men (p=0.000). It was observed that the prevalence was at the peak level in the 3 rd decade, and then decreased proportionally in the following decades (p=0.000). It was also observed that the aphtha recurrence decreased in the following decades (p=0.048). The Behçet's prevalence was found to be 0.60%. The prevalence in women was found to be higher than in men (0.86% female, 0.14% male; p=0.022). Conclusion: While the RAS prevalence ratio was at an average value when compared with the other societies; the BD prevalence was found as the highest ratio in the world according to the literature.

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Section: Recurrent Aphthous Stomatitissupporting

confidence: 81%

Investigation of Behçet's Disease and Recurrent Aphthous Stomatitis Frequency: The Highest Prevalence in Turkey

et al. 2016

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“…Hematinic deficiency has been found in 14.1% to 56.2% of RAS patients . Previous studies have also demonstrated deficiencies of vitamin B12 , red blood cell folate , serum folate , iron , ferritin , vitamin B1 , vitamin B2 , vitamin B6 , Hb , and hematocrit in a portion of RAS patients. The results of diet history questionnaire study indicate a significantly lower daily intake of vitamin B12 and folate in MiRAS patients than in control subjects .…”

Section: Discussionmentioning

confidence: 98%

“…In addition to immune dysregulation, multiple nutritional deficiencies, separately or in combination, are also reported to be the possible etiologies of RAS. Deficiencies of vitamin B12 , folate , iron , ferritin , vitamin B1 , vitamin B2 , and vitamin B6 have been reported in a portion of RAS patients. Therefore, the aim of this study was to assess whether there was an intimate association of the deficiencies of hemoglobin (Hb), iron, vitamin B12, and folic acid as well as high blood homocysteine level with RAS.…”

Section: Introductionmentioning

confidence: 99%

Significant association of deficiencies of hemoglobin, iron, vitamin B12, and folic acid and high homocysteine level with recurrent aphthous stomatitis

Sun

Chen

Cheng

et al. 2014

J Oral Pathology Medicine

110

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“…RAS group had low serum folate 51.7% as well as serum ferritin, serum B12 levels in comparison, healthy subjects [26]. However, Aynali and colleagues have indicated that B12 deficiency may play a role in Folate in Dentistry http://dx.doi.org/10.5772/intechopen.74055 etiology underlying RAS [27]. In their study folate and hemoglobin levels were not statistically different with that of healthy group.…”

Section: Folate In Recurrent Aphthous Stomatitismentioning

confidence: 87%

Folate in Dentistry

Alpan¹,

Karakan²

2018

B Group Vitamins - Current Uses and Perspectives

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Balanced nutrition is the key point of a healthy life includes intake of vitamins and minerals. Vitamins such as folate (B9) have an important role in system homeostasis. Vitamin B derivatives, also folate are water-soluble vitamin class which plays a key role in cell metabolism. Folate is necessary to produce new cells via stimulating DNA and RNA methylation. Folate has positive effect on recurrent aphthous stomatitis, gingival hyperplasia, preventing early childhood caries and periodontal diseases. Alveolar bone and periodontal ligament development are related to sufficient concentrations of folate. Folate reduces gum bleeding, and increases osteoblastic activity and bone mineral density, also decreases osteoclastic activity. Effect on DNA and RNA metabolism causes the reduction of reactive oxygen species. In early stages of pregnancy, folate deficiency may cause birth anomalies due to neural tube defects such as lip, alveolar and palatal clefts. Folate deficiency effects on DNA and RNA metabolism negatively. DNA and RNA repair, production and methylation system is being interrupted. Therefore chromosal abnormalities occur and that situation may cause cancer and leukemia. Folate is mainly provides systemic homeostasis and important for maintaining chromosomal activities. Consequently adequate concentrations of folate must be taken regularly.

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The evaluation of serum vitamin B12, folic acid and hemoglobin levels in patients with recurrent minor aphthous stomatitis

Cited by 8 publications

References 0 publications

Investigation of Behçet's Disease and Recurrent Aphthous Stomatitis Frequency: The Highest Prevalence in Turkey

Investigation of Behçet's Disease and Recurrent Aphthous Stomatitis Frequency: The Highest Prevalence in Turkey

Significant association of deficiencies of hemoglobin, iron, vitamin B12, and folic acid and high homocysteine level with recurrent aphthous stomatitis

Folate in Dentistry

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