THE EVALUATION OF SELECTED BIOACTIVITIES OF FUNGAL MYCELIUM OF A WILD Schizophyllum commune Fr. FROM SUBMERGED CULTURES

Debnath, Sanjit; Hore, Samrat; Das, Pranab Kumar; Saha, Ajay Krishna

doi:10.55251/jmbfs.3250

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…S. commune is a kind of edible and medicinal fungus which contains many bioactive ingredients (Wirth et al 2021). It is a multifunctional fungal cell factory which can produce various metabolites such as hydrolase, bioethanol and biosurfactant, as well as cellulase, pectinase and other enzymes to carry out the hydrolysis of cellulose, hemicelluloses and lignin (Debnath et al 2022). The fermented grains of S. commune can effectively reduce cellular oxidative stress damage caused by UVA irradiation and H 2 O 2 induction through the PI3K-AKT signaling pathway (Cheng et al 2023).…”

Section: Introductionmentioning

confidence: 99%

Reparative Effects of Schizophyllum commune Oat Bran Fermentation Broth on UVB-induced Skin Inflammation via the JAK/STAT Pathway

Song,

Geng,

Wang

et al. 2024

Preprint

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Human immortal keratinocyte cells (HaCaT) are induced with UVB to establish an injury model, which is used as the basis to investigate whether oat bran fermentation broth (OBF) has reparative effect on skin inflammation and damage to the skin barrier due to UVB irradiation. The results show that compared with unfermented oat bran (OB), OBF has higher structural homogeneity, and increased molecular weight size, active substances content and in vitro antioxidant activity. OBF has a scavenging effect on excess ROS and increases the intracellular levels of antioxidant enzymes. In addition, it was found that OBF has a stronger inhibitory effect on the release of inflammatory factors than OB, and increase the synthesis of AQP3 and FLG proteins, and decrease the secretion of KLK-7. OBF can inhibit the transcription level of inflammatory factors by inhibiting the JAK/STAT signaling pathway. Safety experiments show that OBF has a high safety profile.

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Section: Introductionmentioning

confidence: 99%

Reparative Effects of Schizophyllum commune Oat Bran Fermentation Broth on UVB-induced Skin Inflammation via the JAK/STAT Pathway

Song,

Geng,

Wang

et al. 2024

Preprint

View full text Add to dashboard Cite

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Reparative effects of Schizophyllum commune oat bran fermentation broth on UVB-induced skin inflammation via the JAK/STAT pathway

Song,

Geng,

Wang

et al. 2024

Bioresour. Bioprocess.

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Human immortal keratinocyte cells (HaCaT) are induced with UVB to establish an injury model. This model is utilized to investigate whether oat bran fermentation broth (OBF) has a reparative effect on skin inflammation and damage to the skin barrier caused by UVB irradiation. The results show that compared with unfermented oat bran (OB), OBF exhibits higher structural homogeneity, increased molecular weight size, active substances content, and in vitro antioxidant activity. OBF has a scavenging effect on excess reactive oxygen species (ROS) and increases the intracellular levels of antioxidant enzymes. It was found that OBF has a stronger inhibitory effect on the release of inflammatory factors than OB. It increases the synthesis of AQP3 and FLG proteins while decreasing the secretion of KLK-7. OBF can inhibit the transcription level of inflammatory factors by suppressing the JAK/STAT signaling pathway. Safety experiments demonstrate that OBF has a high safety profile. Graphical Abstract

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Update on Mycochemical Profile and Selected Biological Activities of Genus Schizophyllum Fr. 1815

Mišković

Rašeta

Krsmanović

et al. 2023

Microbiology Research

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The aim of this systematic review was to investigate new research on the antioxidant, anti-acetylcholine, antimicrobial, and antitumor activity of genus Schizophyllum, as well as to describe the mycochemical profiles. A summary was made on the published studies in the five-year period from 2017 to 2022, with the focus on the most investigated species of this genus, S. commune. Data were obtained through various scientific online databases, including Google Scholar, Semantic Scholar, PubMed, Science Direct, Elsevier, and Wiley Online Library using specific keywords. Out of 918 records published between 2017 and 2022, a total of 44 peer-reviewed studies were included in qualitative synthesis. Most examined compounds were glucans isolated from the submerged cultivation of S. commune, even though many studies reported proteins, phenolics, and some other secondary metabolites such as flavonoids, saponins, steroids, tannins, triterpenoids, etc. Schizophyllan (SPG), one of the most studied β-glucans isolated from S. commune, has been utilized in clinical trials to treat patients receiving anticancer therapy as an immunopotentiator. Considering the enormous biopotential of genus Schizophyllum, specifically S. commune and S. radiatum, additional attention should be paid to identify the biomolecules more accurately and focus on their antitumor and anti-acetylcholinesterase properties, since they proved to have great prospects in the pharmaceutical and nutraceutical industries.

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THE EVALUATION OF SELECTED BIOACTIVITIES OF FUNGAL MYCELIUM OF A WILD Schizophyllum commune Fr. FROM SUBMERGED CULTURES

Cited by 3 publications

References 6 publications

Reparative Effects of Schizophyllum commune Oat Bran Fermentation Broth on UVB-induced Skin Inflammation via the JAK/STAT Pathway

Reparative Effects of Schizophyllum commune Oat Bran Fermentation Broth on UVB-induced Skin Inflammation via the JAK/STAT Pathway

Reparative effects of Schizophyllum commune oat bran fermentation broth on UVB-induced skin inflammation via the JAK/STAT pathway

Update on Mycochemical Profile and Selected Biological Activities of Genus Schizophyllum Fr. 1815

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