The evaluation of second line drug susceptibilities and molecular epidemiological profiles of multidrug resistance Mycobacterium tuberculosis isolates isoleted from different region of Turkey

Abstract

Introduction:This study was planned to determine the second line drug resistance and molecular epidemiological profiles of multidrug resistant Mycobacterium tuberculosis isolates isolated from different geographical regions of Turkey. Material and Method:In our study, 63 MDR M. tuberculosis isolates were evaluated for the drug susceptibility sent from different tuberculosis laboratories of Turkey. Secondary antituberculosis drugs resistance was evaluated by indirect proportion method. Epidemiological origins were evaluated by using IS6110-RFLP and spoligotyping methods.

Genotyping of Mycobacterium tuberculosis Complex Isolates from Patients with Tuberculosis by MIRU-VNTR and Spoligotyping Methods

“…10 izolatın U spoligotip ailesinin özelliklerini gösterdiği, 11 farklı patern oluşturan 11 izolattan sekizinin Haarlem ve T ailesi, ikisinin Orphan, birinin BOV ailesine ait özellikler taşıdığının tespit edildiği vurgulanmıştır. Çalışma sonucunda LAM7-TUR, LAM9 ve T ailelerinin ülkemizde ve dünyada en yaygın olan aileler olduğu belirtilmiştir (20) . Bizim çalışmamızda ise sırasıyla T, Haarlem ve TUR aileleri en yaygın aileler olarak bulunmuştur.…”