The Evaluation of Roentgen Irradiation as an Adjunct in the Treatment of Acute Otitis Media

Dowdy, Andrew H.; Heatly, Clyde A.; Pierce, William W.

doi:10.1148/32.6.661

Cited by 3 publications

(2 citation statements)

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“…In a series of six cases, which had persisted for many months, the x-ray treatment was effective in only two cases. Dowdy et al 17 selected 27 cases of OM (purulent) treated with tympanostomy/myringotomy alone, 15 cases of OM (purulent) treated with tympanostomy/ myringotomy and low-dose radiation therapy (100 rad once or twice), and 15 cases of catarrhal OM (without pus discharge) treated with low-dose radiation therapy alone (100 rad once or twice). Their results revealed that the average disease duration was lowered from 27.2 to 21.2 days in cases of OM (purulent) treated with myringotomy and low-dose radiation therapy as compared to the cases of OM (purulent) treated with myringotomy alone.…”

Section: Historical Foundations Of Radiotherapy For Om and Mastoiditismentioning

confidence: 99%

Historical use of x-rays

Calabrese

Dhawan

2013

Hum Exp Toxicol

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Purpose: This article provides an historical assessment of the role of radiotherapy in the treatment of inner ear infections. Materials and methods: The research utilized a literature-based evaluation of the use of x-rays during the first half of the 20th century on the treatment of otitis media (OM), mastoiditis, and cervical adenitis and their impact on the occurrence of deafness. Results: X-Rays were consistently found to be effective as a treatment modality at relatively low doses, in the range of 10–20% of the skin erythema dose, rapidly reducing inflammation, and accelerating the healing process. The mechanistic basis of the clinical successes, while addressed by contemporary researchers, is evaluated in the present article in light of current molecular biology advances, which indicate that clinically effective low doses of ionizing radiation act via the creation of an anti-inflammatory phenotype in highly inflamed tissue. Conclusions: X-Ray treatment of OM, mastoiditis, and cervical adenitis was widely accepted in the first half of the 20th century by clinicians as an effective treatment when administered within an appropriate dosage range.

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