2014
DOI: 10.1155/2014/754370
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The Evaluation of Red Cell Distribution Width in Chronic Hemodialysis Patients

Abstract: Background. Red cell distribution width (RDW) has been used as a marker of iron deficiency; however, it is accepted as a marker of cardiovascular survival. We aimed to study RDW levels in hemodialysis (HD) patients and the association between RDW and inflammatory, nutritional, and volume markers. Methods. We included 296 HD patients with sufficient iron storage and without anemia or hypervolemia. We grouped patients into four groups according to clinical parameters, albumin, and C-reactive protein (CRP). Resul… Show more

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Cited by 47 publications
(50 citation statements)
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“…In this study, the significant correlations, though weak, with dialysis vintage, nutritional and inflammatory factors observed were consistent with the previous findings in dialysis patients [12,14,15,34,38] . Besides, patients with higher RDW were more likely to be older and belonged to the female gender.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…In this study, the significant correlations, though weak, with dialysis vintage, nutritional and inflammatory factors observed were consistent with the previous findings in dialysis patients [12,14,15,34,38] . Besides, patients with higher RDW were more likely to be older and belonged to the female gender.…”
Section: Discussionsupporting
confidence: 93%
“…The pathogenesis of RDW increasing in dialysis patients is complex. As shown in previous studies, RDW may reflect anemia and anemia-related nutrient deficiency, abnormal erythropoietin production or erythropoietin hyporesponsiveness [26,27] , impaired renal function [28] , shorter telomere lengths [29] , hypoxia [30] , oxidative stress [31] , endothelial dysfunction [32] , inflammation [33] , malnutrition [34] , volume status [34] , aging [23,24] , reduced physiological reserve [35] , thrombosis [36] , increased erythrocyte fragmentation [37] , and so on. All these conditions are prevalent in dialysis patients and may influence erythropoiesis and erythrocyte survival by both direct and indirect effects, thus leading to an increased RDW.…”
Section: Discussionmentioning
confidence: 97%
“…Feng et al found that RDW was positively correlated with inflammation and malnutrition in a cohort of 1293 peritoneal dialysis patients, and it emerged as an independent predictor of cardiovascular mortality [28]. A similar association was also observed in hemodialysis patients [29]. Moreover, RDW was reported to be related to inflammation, nutrition and mortality in kidney transplant recipients [4].…”
Section: Discussionmentioning
confidence: 83%
“…When these patients were grouped into four categories according to clinical parameters, albumin, and CRP, the group with both low serum albumin (<3.5 g/dl) and high CRP (>5 mg/L) had the highest RDW value. This suggests that even in non-anemic HD patients, RDW levels vary depending on the degree of malnutrition and inflammation 19 .…”
Section: Discussionmentioning
confidence: 99%