The Evaluation of Pancreatic Function by Use of I131 Labeled Fat

Serum studies in man after administration of vitamin A acetate and vitamin A alcohol: II In subjects suffering from disturbances of absorption and digestion

“…2 and 3 are shown comparisons between vitamin A absorption and triolein 1131 and vitamin A absorption and fat balance tests. Shingleton, Baylin, Isley, Sanders, and Ruffin (1957) referred to the contrast in triolein and oleic acid absorption in four cases of pancreatic deficiency. In Fig.…”

“…It has already been pointed out that serum tolerance tests depend on factors other than absorption alone, so it is to be expected that there would be closer correlation between one serum tolerance test and another rather than between a serum tolerance test and a balance test. DISCUSSION Because of the variation in results obtained with vitamin A absorption tests in both normals and abnormals noted by some-authors (Mendeloff, 1954;Hillman and Becker, 1957) this test has been less frequently used than other absorption tests, such as fat balance or the more recently introduced 1131 tagged fats, both of which have been much used (Shingleton et al, 1957;Beres, Wenger, and Kirsner, 1957;Duffy and Turner, 1958). Our experience with the vitamin A tests has led us to conclude that it is a satisfactory test and may have certain advantages over other tests for the following reasons:-It is less laborious than the commonly used fat balance test, both for patients and medical personnel.…”

A Screening Test for Steatorrhoea Using131I-labelled Triolein

“…Since then, most workers have endeavoured to find some relationship between blood radioactivity and disease, following doses of iodinated fat ranging from 25 to 100 ,uc. (Baylin, Sanders, Isley, Shingleton, Hymans, Johnston, and Ruflin, 1955;Malm, Reemtsma, and Barker, 1956;Sanders, Isley, Sharpe, Baylin, Shingleton, Hymans, Ruffin, and Reeves, 1956;Ruffin, Shingleton, Baylin, Hymans, Isley, Sanders, and Sohmer, 1956;Shingleton, Baylin, Isley, Sanders, and Ruffin, 1957;McKenna, Bourne, and Matzko, 1957;Beres, Wenger, and Kirsner, 1957). In a few cases, radioactivity measurements were made on the faeces and in still fewer cases parallel determinations of radioactivity and fat were carried out.…”

Resorption von J131-markierten Fetten und radioaktivem Vitamin B12

“…Aus diesem Grunde sind die J 131 -Blutwerte normal, was auch durch normale Fettbilanzen bestätigt wird. Wenn die Störung in einer ungenügenden Fettverdauung liegt, wie es bei der chronischen Pankreatitis, bei partiellen Magenresektionen u. a. der Fall ist, so werden die Triglyzeride (Triolein) ungenügend, dagegen Fettsäuren normal resorbiert (17,37,54,60,61,62,63,47). Wenn die Resorption abnormal ist, wie es bei der Steatorrhoe, der regionalen Enteritis, der partiellen Dünndarmresektion, der gastrokolischen Fistel u. a. der Fall ist, so werden sowohl Triolein als auch Fettsäuren ungenügend resorbiert (37,60,61,62,63,42,21,24).…”