The Evaluation of p53 Polymorphism at Codon 72 and Association With Breast Cancer in Iran: A Systematic Review and Meta-analysis

Soleimani, Abozar; Rahmani, Yousef; Farshchian, Nazanin; Delpisheh, Ali; Khassi, Kivan; Shahmohammadi, Afshar; Amirifard, Nasrin

doi:10.15430/jcp.2016.21.4.288

Cited by 9 publications

(9 citation statements)

References 21 publications

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“…Two separate meta-analyses by Jia et al (36) and Lao et al (37) suggested that the homozygote and heterozygote genotypes of Pro participated in the development of endometriosis in Asian and Caucasian populations. Analysis of this variant among an Iranian population revealed that the Arg genotype increased the risk of breast cancer while Pro served as a protective factor (38). As study limitations, the two population groups were not matched based on age or gender, and there was no evaluation of H. pylori infections, lifestyle or dietary regime.…”

Section: Discussionmentioning

confidence: 99%

Association of P53 gene polymorphism with gastric cancer in Northern Iran as a high‑risk region

et al. 2018

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Abstract. Gastric cancer has the fourth highest morbidity rate of all cancers worldwide. Genetic factors including alterations in oncogenes and tumor suppressor genes serve an important role in gastric cancer development and progression. The P53 gene acts as a tumor suppressor gene by regulating the cell cycle, DNA transcription and repair, apoptosis, senescence and genome stability. In addition to somatic P53 mutations in cancer development, germline polymorphisms are also involved in different malignancies. The polymorphism of P53 at codon 72 (Arg72Pro) is established as a common variant that increases susceptibility to various cancers. The present case-control study was conducted to evaluate the possible association between this P53 polymorphism and gastric cancer in the Iranian population. A total of 59 patients with gastric cancer and 59 healthy controls were enrolled in the present study. Genomic DNA was extracted from peripheral blood mononuclear cells and genotype analysis was performed using a polymerase chain reaction-based restriction fragment length polymorphism assay. Genotype frequencies did not differ significantly between the patients and controls (P=0.4); the frequencies of the three genotypes Arg/Arg, Arg/Pro and Pro/Pro in gastric cancer patients were 28.8, 49.2 and 22.0%, and in controls were 37.3, 49.2 and 13.6%. Additionally, there were no differences in genotype frequencies based on tumor location, histological differentiation or tumor stage. Based on these findings, it may be concluded that the P53 codon 72 polymorphism does not contribute to gastric cancer susceptibility in Northern Iran. IntroductionGastric cancer has the third highest mortality and fourth highest morbidity rates of all cancers worldwide (1). In 2012, GloboCan statistics reported almost 1 million new cases of gastric cancer, and more than 700,000 mortalities caused by gastric cancer (1). Gastric cancer is a multifactorial disorder, in which genetic and environmental interactions serve an important role in development and progression (2). Increasing age, gender, lifestyle, dietary regime, environmental factors and Helicobacter pylori infections are among the known risk factors for stomach cancer (3,4). While dietary regime and lifestyle are the most recognized factors, more effective identification of the genetic risk factors is expected to improve understanding of the basic molecular events involved in tumorigenesis (5). Various genetic and epigenetic changes that have the potential to convert normal epithelial cells in the stomach into malignant neoplasms may be responsible for the development of both familial and sporadic gastric cancer (6,7). Studies performed recently have demonstrated that a high number of genes and various environmental factors are the causal agents of gastric cancer, and the presence of different forms of alleles in genes (polymorphisms) may promote the development of cancers; in this regard, the P53 gene has been a research focus due to its role as a major tumor suppressor gene (8,9). The P53 ge...

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Section: Discussionmentioning

confidence: 99%

Association of P53 gene polymorphism with gastric cancer in Northern Iran as a high‑risk region

et al. 2018

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“…The Arg72Pro functional polymorphism of TP53 has been widely assessed in cancer susceptibility studies that have yielded contradictory results. In Iran, investigations on this SNP in primary open angle glaucoma (50) and breast (25) and colorectal (21) cancers have indicated associations with disease risk, but no evidence of association has been identified in gastric (51,52) and head and neck (53) cancer, oral squamous cell carcinoma (54) and also hepatitis C infection (55).…”

Section: Discussionmentioning

confidence: 99%

“…TP53 mutations may increase cellular expansion, loss of apoptosis and genetic instability (23,24). In this regard, a single nucleotide polymorphism (SNP) on codon 72 of TP53 (rs1042522), which encodes proline (CCC) or arginine (CGC), appears to be associated not only with the risk of certain malignant (e.g., cancers of the breast and gastrointestinal system) (25,26) and chronic diseases (e.g., diabetic nephropathy) (15,27) but also with patient survival and treatment response (28,29 characteristics of these two varieties are distinct, which may influence the ability of the final protein to induce inflammation or apoptosis (30). When considering the role of TP53 in the regulation of cell growth, proliferation and inflammatory processes, previous studies have identified inconclusive results in patients with CAD (31)(32)(33).…”

Section: Introductionmentioning

confidence: 99%

TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease

et al. 2018

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Abstract. Chronic diseases including coronary artery disease (CAD) impose a high burden in terms of mortality and disability particularly in developing countries. Both genetic and environmental risk factors confer susceptibility to CAD. Meanwhile, a functional polymorphism in the tumor protein p53 (TP53) gene (codon 72, exon 4) has been reported to be associated with a wide range of cancers and inflammatory disorders. There are controversies regarding CAD and involvement of the TP53 codon 72 single nucleotide polymorphism; therefore, the present case-control study was conducted to evaluate the potential association between this TP53 polymorphism and CAD in an Iranian population. A total of 153 subjects (including 70 patients diagnosed with CAD and 83 subjects with normal coronary parameters, determined by angiography) were genotyped for the TP53 (rs1042522) polymorphism by the polymerase chain reaction-restriction fragment length polymorphism technique. Clinical and laboratory findings were also evaluated. The χ 2 test and unpaired Student's t-test were applied to compare genotype and allele distributions and clinical characteristics between the two groups. Significant associations of the Pro72 allele [odds ratio (OR)=1.66, P=0.027] and Pro/Pro genotype (OR=2.91, P=0.022) with CAD were identified. No associations between patients' clinical findings and genotypes were apparent. Therefore, according to present findings, the TP53 Pro72 allele may be involved in the development of CAD along with conventional risk factors in patients from Northern Iran.

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“…[4] Several risk factors have been explained for BC developing, including genetic background, environmental factors, family history, menstrual and pregnancy status, early menarche, age of menopause, alcohol consumption, and also the previous history of cancer. [4] BC grading and staging play an important role in the prognosis of BC and have been discussed about for many years. Further investigations led to the discovery of human epidermal growth factor receptor-2 (Her-2) marker that acts as an important therapeutic and prognostic factor.…”

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confidence: 99%

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Naimi¹

2018

AJP

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Introduction: Difference in human epidermal growth factor receptor-2 (Her-2) expression in metastatic axillary lymph nodes and primary breast tumor may affect treatment response, as studies have shown that change of therapy according to lymph node metastasis biomarker expression, improved patient prognosis. The aim of current study is to evaluate the Her-2 expression in primary breast cancer (BC) and its accordance with metastatic axillary lymph nodes. Materials and Methods: This is a cross-sectional study on 70 patients with BC conducted in Isfahan University of Medical Sciences. Age, number of involved lymph nodes, Her-2, estrogen receptor (ER), and progesterone receptor expression and in case of Her-2 expression, its grade in primary BC were recorded. Her-2 expression was evaluated in the metastatic axillary lymph node by immunohistochemistry method. Results: The mean age of patients who had concordance was 51.2 ± 13.1 and those who did not have this association was 48.9 ± 12.1 (P = 0.45). 48.6% of samples showed discordance of primary BC and lymph node metastasis. In ER-positive patients, 42.9%, and in ER-negative group, 60%, revealed concordance. In discordance group, 50% revealed Grade 1, 43.2% Grade 2 and 61.5% Grade 3. Discussion: Lower number of metastatic lymph nodes was significantly associated with Her-2 expression concordance. Our study found positive conversion in 12.5% of patients who have primary BC negative results with positive metastatic lymph nodes and 42.1% of negative conversion. In the current study, we found a high rate of discordance of Her-2 expression in primary BC with metastatic lymph nodes. The number of metastatic lymph nodes affected Her-2 expression concordance diversely.

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The Evaluation of p53 Polymorphism at Codon 72 and Association With Breast Cancer in Iran: A Systematic Review and Meta-analysis

Cited by 9 publications

References 21 publications

Association of P53 gene polymorphism with gastric cancer in Northern Iran as a high‑risk region

Association of P53 gene polymorphism with gastric cancer in Northern Iran as a high‑risk region

TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease

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