The Evaluation of Neutrophil-Lymphocyte Ratio in Alzheimer’s Disease

Abstract

Background/Aim: There is growing consensus in the literature that inflammation plays a significant role in the pathophysiology of Alzheimer’s disease (AD). The blood neutrophil-lymphocyte ratio (NLR) is a new, inexpensive and easily applicable marker of inflammation. The aim of this study was to investigate the association between NLR, as an inflammatory biomarker, and AD. Methods: 241 AD patients and 175 patients with normal cognitive function were evaluated in this study. Results: The mean ± SD NLR of AD patients was significantly higher than that of patients with normal cognitive function (3.21 ± 1.35 vs. 2.07 ± 0.74, p < 0.001, respectively). Receiver operating characteristic curve analysis suggested that the optimum NLR cutoff point for AD was 2.48 with 69.29% sensitivity, 79.43% specificity, 82.30% positive predictive values and 65.30% negative predictive values. Logistic regression analysis showed that elevated NLR (OR: 4.774, 95% CI: 2.821–8.076, p < 0.001) was an independent variable for predicting AD. Conclusion: Elderly people with AD have higher NLR than healthy controls. Elevated NLR levels are usually considered as an inflammatory marker. The results of this study suggested that inflammation plays a role in the pathogenesis of AD.

The Relationship Between Neutrophil to Lymphocyte Ratio and Recurrent Aphthous Stomatitis

“…In previous studies, increased NLR was demonstrated in cardiovascular and cerebrovascular diseases such as hypertension, unstable angina pectoris, myocardial infarction, transient ischemic attacks and stroke [9][10][11][12][13]. Moreover NLR has been found as a valuable index for predicting clinical outcomes in oncology [14][15][16][17] and inflammatory diseases such as Alzheimer, ulcerative colitis and appendicitis [18][19][20] . To our knowledge, this is the first study investigating the relationship between NLR levels and RAS.In this study we found that NLR levels in patients with RAS were higher than the control group.…”

The Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Markers for Prognosis in Idiopathic Sudden Sensorineural Hearing Loss

“…PTA: pure tone average. cardiology (acute coronary syndromes, heart failure, and coronary revascularization procedures); end-stage renal disease; and inflammatory diseases such as Alzheimer, ulcerative colitis, and appendicitis [21,22]. A higher NLR indicates a higher level of inflammation [23].…”

Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder

“…(3) There was no difference among the patient groups (manic, depressed, and euthymic) in terms of NLR and PLR. NLR has been reported in recent years as a peripheral inflammation marker in several neuropsychiatric disorders [29][30][31][32]36]. NLR was reported to be significantly higher in Alzheimer's disease and schizophrenia when compared to controls [29,30].…”

“…NLR has been reported in recent years as a peripheral inflammation marker in several neuropsychiatric disorders [29][30][31][32]36]. NLR was reported to be significantly higher in Alzheimer's disease and schizophrenia when compared to controls [29,30]. Studies in which inflammatory mechanisms play a role in the aetiology of BD are becoming increasingly important.…”

“…Increased levels of NLR were reported to be indicative enhanced cytokine production [28]. NLR was investigated as a systemic inflammation marker in neuropsychiatric disorders such as Alzheimer's disease [29] and schizophrenia [30]. There have also been studies investigated NLR and PLR in BD.…”