The evaluation of left ventricular dyssynchronization in patients with hypertension by phase analysis of myocardial perfusion-gated SPECT

Özdemir, Semra; Kırılmaz, Bahadır; Barutçu, Ahmet; Tan, Yusuf Ziya; Çelik, Fatmanur; Akgöz, Semra

doi:10.1007/s12149-014-0933-7

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…Previous studies for detecting LV systolic functions in EHT patients depend mainly on tissue Doppler imaging (TDI), cardiac magnetic resonance imaging (cardiac MRI), and cardiac radionuclide imaging. [2][3][4] However, these techniques all have limitations, like angle dependence in TDI, 5,6 long-term examination in cardiac MRI, and radioactivity of cardiac radionuclide imaging. Two-dimensional speckle-tracking echocardiography (2D-STE) has become one of the leading reliable diagnostic techniques for the assessment of cardiac functions because of its non-invasiveness, convenience, and repeatability.…”

Section: Introductionmentioning

confidence: 99%

Global myocardial work: A new way to detect subclinical myocardial dysfunction with normal left ventricle ejection fraction in essential hypertension patients: Compared with myocardial layer‐specific strain analysis

et al. 2021

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Objectives:The aim of this study was to determine whether global myocardial work (MW), derived from non-invasive left ventricle (LV) pressure-strain loops (PSL) at rest, could predict subclinical LV myocardial dysfunction in preserved left ventricular ejection fraction (LVEF) essential hypertension (EHT) patients. Methods: A total of 105 untreated EHT patients and 55 normal controls were enrolled in this study. Apical 4-, 3-and 2-chamber views were acquired by two-dimensional echocardiography. The peak systolic myocardial layer-specific longitudinal strain (epimyocardial: GLSEpi; middle layer: GLSMid; and endomyocardial: GLSEndo), global myocardial work index (GWI), global constructive work (GCW), global wasted work (GWW), and myocardial work efficiency (GWE) were generated by speckle-tracking echocardiography (STE).Results: The values of GLSEpi, GLSMid, and GLSEndo were significantly lower in EHT patients with LVH than in EHT patients without LVH and normal controls. GWW was significantly increased in EHT patients with LVH compared with without LVH and normal subjects, while GWE was significantly reduced in EHT patients with LVH compared with without LVH and normal subjects. ROC analysis showed that combined global MW values were a more sensitive predictor for detecting the accuracy of LV subclinical dysfunction in EHT patients than layer-specific GLS. Conclusion:From the research, we conclude that global MW is more sensitive to layer-specific GLS in its ability to detect subclinical LV dysfunction even in EHT patients even without LVH.

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Section: Introductionmentioning

confidence: 99%

Global myocardial work: A new way to detect subclinical myocardial dysfunction with normal left ventricle ejection fraction in essential hypertension patients: Compared with myocardial layer‐specific strain analysis

et al. 2021

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“…A study conducted by Ozdemir evaluated 196 normal myocardial perfusion scintigraphy scans of patients with and without SAH and showed statistically significant differences between the groups. The SAH group showed higher standard deviations (SD) and histogram bandwidth (HBW) (p < 0.005 and p < 0.001, respectively) 28 . Besides, by analyzing the subgroup of patients with SAH and diabetes mellitus (DM), we observed higher levels of SD and HBW than in the SAH subgroup only.…”

Section: Use Of Gated Spect With Phase Analysis In the Evaluation Of mentioning

confidence: 99%

Applicability of Myocardial Perfusion Scintigraphy in the Evaluation of Cardiac Synchronization

Reis¹,

Nascimento²,

Dias³

et al. 2017

Arquivos Brasileiros De Cardiologia - Imagem Cardiovascular

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To systematically assess the literature on the applicability of myocardial perfusion scintigraphy with phase analysis in the investigation of cardiac dyssynchrony and in the selection of patients for cardiac resynchronization therapy (CRT), manuscripts published on the PubMed database over the past five years have been reviewed. The following MeSH terms were used: heart failure, left ventricular, dyssynchrony, gated-spect, phase analysis and resynchronization therapy. Altogether, 99 manuscripts were included for discussion. Speckle-tracking echocardiography is still widely used in the evaluation of dyssynchrony, but the advent of myocardial perfusion scintigraphy with the phase analysis technique has been gaining ground, as besides being operatorindependent, it can evaluate myocardial viability in the same test. Its use became more widespread in patients with left bundle branch block, with recommendation of CRT. Phase analysis also allows evaluating, in a highly reproducible way, the last ventricular segment to contract, hence allowing the best positioning of the CRT electrode. Knowing that the presence, location and extent of fibrosis in the left ventricle, associated with dyssynchrony are determinants of response to resynchronization therapy, gated-SPECT can provide this information in a single test and in a reproducible and accurate way. Phase histogram offers several parameters that provide greater sensitivity and specificity to the method. It seems that the technique is able to add value both in the selection and in the evaluation of response of patients eligible to CRT. Further studies are being conducted to demonstrate its clinical applicability.

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Left ventricular mechanical dyssynchrony assessment in obese patients using the cadmium-zinc telluride SPECT camera

Zhang

Fan

Qin

et al. 2020

Int J Cardiovasc Imaging

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The evaluation of left ventricular dyssynchronization in patients with hypertension by phase analysis of myocardial perfusion-gated SPECT

Abstract: This study suggested that routine use of phase analysis-gated SPECT imaging will be beneficial for the diagnosis of LVD.

Cited by 6 publications

References 35 publications

Global myocardial work: A new way to detect subclinical myocardial dysfunction with normal left ventricle ejection fraction in essential hypertension patients: Compared with myocardial layer‐specific strain analysis

Global myocardial work: A new way to detect subclinical myocardial dysfunction with normal left ventricle ejection fraction in essential hypertension patients: Compared with myocardial layer‐specific strain analysis

Applicability of Myocardial Perfusion Scintigraphy in the Evaluation of Cardiac Synchronization

Left ventricular mechanical dyssynchrony assessment in obese patients using the cadmium-zinc telluride SPECT camera

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