The evaluation of endocrine regulators after intramuscular and oral application of cyanogenic glycoside amygdalin in rabbits

Abstract

The present

Potential toxicity of cyanogenic glycoside amygdalin and bitter apricot seed in rabbits—Health status evaluation

“…Results of our previous apricot seeds/amygdalin studies described variety of effects, for example, small weight loss in humans after daily consumption of bitter apricot seeds (Kopčeková et al, ), significant decreasing effect on total cholesterol and LDL cholesterol levels in humans after 12 weeks of consumption (Kopčeková et al, ), effect on mineral management of the human body (Tušimová, Kováčik et al, ; Tušimová, Zbyňovská et al, ), potential impact on steroidogenesis in porcine granulose cells in vitro (Halenár, Medveďová, Maruniaková, & Kolesárová, ), but no effect on endocrine regulators in vivo (Halenár et al, ) and a slight increase in renal parenchyma dystrophy of rabbits fed apricot seeds (Kolesárová et al, ).…”

Assessment of rabbit spermatozoa characteristics after amygdalin and apricot seeds exposure in vivo

“…Previous studies describe the effect of AMG on reproductive functions in animals [19] , [20] , [21] , [22] , [13] , [23] , [10] . In our in vivo study on rabbit model the effects of intramuscular application of AMG and oral consumption of apricot seeds were evaluated.…”

“…Based on the amygdalin content in apricot seeds, the experimental groups P3 and P4 received 3.12 and 15.6 mg/kg b.w. of amygdalin, corresponding to 0.18 and 0.92 mg/kg HCN, respectively [13] . The body weight of each experimental animal was recorded weekly during the whole study.…”

The Effect of Apricot Seeds on Microscopic Structure of Rabbit Liver

“…Thin Layer Chromatography (TLC) was performed for the analysis of amygdalin content in bitter apricot seeds used in our experiment. The chemical composition of the apricot seeds was carried out (Halenar et al, 2017). Animals 45 days old were randomly divided into four groups (C-control, P1, P2, P3-experimental groups) leading to 4 male rabbits in each group.…”

“…The field of nutritional research focuses on phytonutrients and their beneficial properties on health. Phytonutrients, which include in particular polyphenols, flavonoids (isoquercitrin, rutin, quercetin, and others) (Roychoudhury et al, 2018;Kolesarova et al, 2019), ellagitannins, especially punicalagin and ellagic acid (Packova et al, 2015), glycosides (amygdalin) (Halenar et al, 2015(Halenar et al, , 2017Kolesar et al, 2018;Kopcekova et al, 2018;Kovacikova et al, 2019) and others are known to possess potential antioxidant and antitumor activity and the ability to eliminate environmental stress-induced reprotoxicity (Kolesarova et al, 2012;Halenar et al, 2015). Cancer is a major public health problem worldwide and is the second leading cause of death in the United States (Siegel et al, 2018).…”