The evaluation of crown ether based niosomes as cation containing and cation sensitive drug delivery systems

Temperature-dependent IR spectroscopic and structural study of 18-crown-6 chelating ligand in the complexation with sodium surfactant salts and potassium picrate

“…The group of macrocyclic polyethers, known as crown ethers, have become valuable tools in organic synthesis due to their ability to solvate alkali, alkaline-earth, transition-metal, and ammonium cations [1][2][3][4]. Their selective cation binding makes them applicable for different environmental usage [5,6], drug delivery [7,8], recovery or removal of specific species, models for biological receptors [9], reaction catalysts as well as active sites in ion selective electrodes [10] or chromatographic agents [11]. Alkali metal elements have indispensable role in many biological processes, primarily to be as bulk electrolytes that stabilize surface charges on proteins and nucleic acids [12], and also play unique structural roles in biological systems [13,14].…”

Drug Delivery by Soft Matter: Matrix and Vesicular Carriers

“…[97] Notably, surfactant niosomes have been obtained with glycerol, [98] ethylene oxide, [99] crown ethers, [100] and polyhydroxylated [101] or sugar-based [102] polar headgroups.…”

Wirkstofftransport mit weicher Materie: Matrix‐ und Vesikelvektoren

“…In der Literatur wurden verschiedene Herstellungsmethoden für Niosome beschrieben. [97] Wie [97] Insbesondere wurden Niosome aus Tensiden hergestellt, die Glycerin-, [98] Ethylenoxid-, [99] Kronenether-, [100] polyhydroxylierte [101] oder von Zuckern abgeleitete [102] Hinsichtlich der Herstellung dieser Systeme muss man zwischen katanionischen Mischungen und katanionischen Tensiden (reinen Ionenpaarsystemen) [104] unterscheiden. Mit der zweiten Kategorie sind Systeme gemeint, in denen die anorganischen Gegenionen, die ursprünglich mit den amphiphilen Ionen assoziiert waren, entfernt wurden.…”