The Evaluation of Anti-wrinkle Effects in Oriental Herb Extract

강금석,; 김인덕,; 권륜희,; 허예영,; 오상훈,; 김민아,; 정혜진,; 강환열,; 하배진,

doi:10.5352/jls.2007.17.8.1147

Cited by 18 publications

(3 citation statements)

References 6 publications

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“…In the cosmetics market, senior generation women have emerged as a high consumer and a high purchasing power, and they are a big part of important consumers [2]. As the number of senior generation women who want young and resilient skin increases, the demand for functional cosmetics that improve wrinkles with excellent efficacy has increased, and the cosmetics industry is actively pursuing research on this [3].…”

Section: Introductionmentioning

confidence: 99%

A Clinical Study on Anti-wrinkle Efficacy of a Cosmetics Containing Oligoarginine Conjugation of Palmitoyl-GHK peptide for Skin Penetrating

Park¹,

Heo²,

Lee³

et al. 2021

TURCOMAT

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In this study, Arg 4 (R4) was conjugated with Pal-GHK to get palmitoyl heptapeptide, Pal-GHK‐R4 and wrinkle improvement clinical trials of cosmetics containing Pal-GHK‐R4 were conducted. As a result of total 21 subjects used the test products 4 weeks use on the face area; 1) measurement results of crow’s feet after 2 and 4 weeks of test products use, analysis value of crow’s feet statistically significantly decreased after 2 and 4 weeks of test products use compared to before use of products (p<0.05); 2) measurement results of skin moisturization after 2 and 4 weeks test products use, measured value of skin moisture content statistically significantly increased after 2 and 4 weeks use compared to before use of products (p<0.05); 3) measurement results of TEWL after 2 and 4 weeks use, measured value of TEWL statistically significantly decreased after 2 and 4 weeks use compared to before use of product(p<0.05); 4) there was no skin adverse event reported after using the products during the study period. Therefore, the test products containing both wrinkle improving and skin penetrating peptides, Pal-GHK‐R4 are considered to have beneficial effects on improvement of skin wrinkle, moisturization, transepidermal water loss(TEWL) after 2 and 4 weeks use of test product.

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Section: Introductionmentioning

confidence: 99%

A Clinical Study on Anti-wrinkle Efficacy of a Cosmetics Containing Oligoarginine Conjugation of Palmitoyl-GHK peptide for Skin Penetrating

Park¹,

Heo²,

Lee³

et al. 2021

TURCOMAT

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“…멜라닌은 melanosome 내부에서 생성되고 아미노산인 L-tyrosine 이 효소인 tyrosinase에 의해 dopaquinone으로 전환된다. 그러나 과도한 멜라닌 생성은 흑색증, 염증 후 색소 침착, 주근깨 또는 종자와 같은 상태에서 상당한 문제를 일으킬 수 있다 [10]. 기능 성화장품 개발 관련 연구에서는 피부 미백과 주름 개선 효능이 있는 다양한 소재 연구가 활발하게 진행되고 있으며 특히 웰빙 트렌드 확산으로 안전하고 우수한 효능을 함유한 천연 소재 개 발에 초점을 맞추고 있다 [11,12].…”

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Whitening and anti-wrinkle effect ofSpirodela polyrhizaextracts

Kim

Park

Kim

2019

JABC

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The antioxidant, whitening, and anti-wrinkle activity of Spirodela polyrhiza extracts and fractions were evaluated to determine its efficacy as a functional cosmetic material. 1,1diphenyl-2-picrylhydrazyl and 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid radical scavenging activities were 44.2 and 74.3%, respectively, at 100 µg/mL of SE-E (the ethyl acetate fraction of 70% ethanol extract). To measure anti-wrinkle effects, procollagen biosynthesis and matrix metalloproteinase-1 (MMP-1) inhibition activity were determined. At 25 µg/mL of SE (70% ethanol extract), the biosynthesis activity was 48.5%, and SE-E showed the best activity (57.8%) at the same concentration. MMP-1 inhibition activity of SE and SE-E was 13.4 and 28.5%, respectively, at 25 ìg/mL. Finally, the inhibition of cellular melanin synthesis and cellular tyrosinase were measured to determine the whitening effect; at 25 µg/mL, the inhibition activities of SE were 9.6 and 13.8%, respectively, and those for SE-E were 15.4 and 22.0%, respectively. Our results confirmed the possibility of SE and SE-E as effective functional materials. Further research investigating the antimicrobial, anti-inflammatory, and anticancer activities of S.polyrhiza is necessary to confirm its potential use in the food, cosmetics, and drug industries.

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“…ascorbic acid, α-tocopherol, carotenoid, flavonoid, butylated hydroxy toluene (BHT), butylated hydroxy anisole (BHA), propylene glycol (PG) 등 이 있 으 며 (Dziezak, 1986), (Rim et al, 2005;Branen, 1975;Jung et al, 2004;Kang et al, 2007). (Park, 1997).…”

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confidence: 99%