The Evaluation of Albumin Use in an Iranian University Hospital

Shafiee, Elaheh; Rezaee, Haleh; Entezari, Taher; Hamishehkar, Hadi

doi:10.15171/ps.2016.29

Cited by 9 publications

(26 citation statements)

References 12 publications

(18 reference statements)

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“…Previous albumin use evaluations revealed a substantial need for educational, administrative or regulatory actions to address common inappropriate uses of albumin . In spite of uncertainty regarding the effectiveness of the approaches to optimize medication use in the hospitals, a combination of interventions is assumed to be more effective .…”

Section: Resultsmentioning

confidence: 99%

“…In the first and second phases of the study, the most common use in terms of orders Previous albumin use evaluations revealed a substantial need for educational, administrative or regulatory actions to address common inappropriate uses of albumin. [17][18][19][20][21][22] In spite of uncertainty regarding the effectiveness of the approaches to optimize medication use in the hospitals, a combination of interventions is assumed to be more effective. 23 In this study, we assessed the effect of two sequential interventions (institutional albumin guideline followed by albumin order sheet) on albumin use in our hospital.…”

Section: Oncology and Hematopoietic Stem Cell Transplantation (Hsct) mentioning

confidence: 99%

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Effect of hospital-wide interventions to optimize albumin use in a tertiary hospital

et al. 2017

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The pattern and amount of albumin use changed following guideline implementation and order-sheet consideration, and inappropriate albumin use was reduced in our hospital. There was still room for improvement, particularly for indications that were not included in the guideline. Hence, a more comprehensive guideline, frequent audit, feedback and interactive educational approaches might be necessary to achieve results that are of a greater magnitude.

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Section: Resultsmentioning

confidence: 99%

Section: Oncology and Hematopoietic Stem Cell Transplantation (Hsct) mentioning

confidence: 99%

Effect of hospital-wide interventions to optimize albumin use in a tertiary hospital

et al. 2017

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Section: Discussionmentioning

confidence: 99%

“…In the past three decades, clinical studies from different countries have indicated that at least 50% to more than 90% of albumin prescriptions are inappropriate [ 10 – 13 ]. Overuse of albumin can be challenging for healthcare systems due to its high cost, limited availability, and potential risk of pathogen transmission [ 10 ]. Regarding the costs, a report by the Iranian Food and Drug Organization of Health Ministry indicated that 472,089 vials of albumin 20% have been used within the first 9 months of 2008, which amounts to $21,600,000 (13).…”

Section: Discussionmentioning

confidence: 99%

“…Tanzi et al in a study on 1672 patients from 53 different healthcare facilities in the USA showed that all 142 indications of albumin for individuals with serum albumin levels below 2 g/dL were inappropriate [ 12 ]. It has been demonstrated that enteral and/or parenteral nutrition with amino acids, along with adequate calorie intake rather than albumin, can improve serum albumin level in malnourished patients [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

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Clinical and economical impacts of guideline implementation by the pharmaceutical care unit for high cost medications in a referral teaching hospital

Vazin

Karimzadeh

Karamikhah

et al. 2018

BMC Health Serv Res

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BackgroundIrrational drug use is a global health challenge in all healthcare settings, such as hospitals. This study evaluated the impact of an intervention by the pharmaceutical care unit on the use pattern of high-value medications and their direct costs in a referral hospital.MethodsThis interventional, prospective study was carried out in clinical wards of Namazi Hospital (Shiraz University of Medical Sciences) during six months from May 2015 to October 2015. Clinical pharmacists completed the checklists for albumin, intravenous (IV) pantoprazole, and IV immune globulin (IVIG), as three high-cost medications. When ordering these medications, the physicians were asked to complete the checklists. Then, trained pharmacists examined the checklists, based on the clinical and paraclinical conditions.ResultsThe total number of administered medications and their relative cost decreased by 50.76% through guideline implementation; the difference was significant (P < 0.001). In addition, the direct cost of albumin and IV pantoprazole significantly decreased (55.8% and 83.92%, respectively). In contrast, the direct cost of IVIG increased by 40.9%. After guideline implementation, the monthly direct cost of all three medications decreased by $77,720 (55.88%). The all-cause in-hospital mortality rate did not change significantly due to the intervention. The median length of hospital stay was six and seven days, respectively in the pre- and post-intervention periods.ConclusionBased on the findings, implementation of guidelines by the pharmaceutical care unit caused a significant reduction in albumin and IV pantoprazole consumption and reduced their direct costs in a referral center in Iran.Electronic supplementary materialThe online version of this article (10.1186/s12913-018-3627-3) contains supplementary material, which is available to authorized users.

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Prescribers’ Compliance to Human Serum Albumin Usage Criteria and Its Implication on Cost Saving

Sukkha,

Sangroongruangsri,

Malaphan

et al. 2023

Journal of Health Management

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Human serum albumin (HSA) is a commonly used product with high impact on healthcare expenditure. Little is known regarding the appropriateness of HSA use in healthcare system. This study aimed to assess prescriber’s compliance to the approved HSA criteria. Potential cost saving was also estimated. A cross-sectional study was performed in a tertiary care, university hospital in Bangkok in 2019. Prescriptions for HSA for all adult patients along with corresponding medical records were reviewed and assessed against the approved HSA criteria. Deviation from the criteria was used to estimate the potential cost saving. A total of 688 prescriptions were reviewed, 200 prescriptions met the inclusion criteria and were included in the analysis. Among six indications in the approved criteria for HSA, the rates of criteria compliance ranged from 48 to 90%. Hypoalbuminemia was found to be the main reason for inappropriate use. The estimated cost saving from inappropriate HSA use was €3,543 (€59 per prescription). Significant deviation from the approved criteria of HSA use was seen in a Thai hospital and significant cost saving can be made by increasing the compliance to the criteria. A practice improvement initiative to promote rational use of HSA is warranted.

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The Evaluation of Albumin Use in an Iranian University Hospital

Cited by 9 publications

References 12 publications

Effect of hospital-wide interventions to optimize albumin use in a tertiary hospital

Effect of hospital-wide interventions to optimize albumin use in a tertiary hospital

Clinical and economical impacts of guideline implementation by the pharmaceutical care unit for high cost medications in a referral teaching hospital

Prescribers’ Compliance to Human Serum Albumin Usage Criteria and Its Implication on Cost Saving

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