The evaluation of adverse drug reactions in Saudi Arabia: A retrospective observational study

Alenzi, Khalidah A.; Alanazi, Najah Salah F; Almalki, Mohammed; alomrani, Homoud; Alatawi, Fahad O.

doi:10.1016/j.jsps.2022.03.018

Cited by 4 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antimicrobials accounted for the majority of ADRs in the present study and similar which could be due to the fact that antimicrobial drugs are the commonly prescribed drugs. This was consistent with study by Alenzi et al whereas on the contrary antineoplastic drugs predominated in a study by Digra et al [10,23,24]. The skin and appendages constituted the most common organ system affected with commonest reaction between rash and urticaria.…”

Section: Discussionsupporting

confidence: 91%

“…The recent epidemiological studies have reported that ADR are the fourth to sixth leading causes of death [1,8,9]. The WHO defined "Pharmacovigilance" as "The science and activities related to the detection, assessment, understanding and prevention of adverse drug effects or any other possible drug-related problems [3,10]." Despite the various shortcomings of the spontaneous ADR reporting systems, they still remain as the most prevalent method within Pharmacovigilance centers across the world, which permits, ongoing evaluation, and continues to be one of the best ways for early detection and prevention of unexpected and uncommon ADRs [3,10,11].…”

Section: Introductionmentioning

confidence: 99%

“…The WHO defined "Pharmacovigilance" as "The science and activities related to the detection, assessment, understanding and prevention of adverse drug effects or any other possible drug-related problems [3,10]." Despite the various shortcomings of the spontaneous ADR reporting systems, they still remain as the most prevalent method within Pharmacovigilance centers across the world, which permits, ongoing evaluation, and continues to be one of the best ways for early detection and prevention of unexpected and uncommon ADRs [3,10,11]. In the absence of excellent ADR reporting systems, multiple preventable causes of ADRs may remain undetected for significant period of time, which amplifies the unexpected negative outcomes encountered in patient care [9,[12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…It is well known that elderly population are at higher risk of ADRs due to associated risk factors such as co-morbidities, polypharmacy, irrational use of prescriptions, and improper monitoring [10,11,15,16]. The WHO defines older adults (elderly or geriatrics) as those aged 60 years and older [11,17,18].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

An Analysis of the Pattern and the Risk Factors of Adverse Drug Reactions at a Tertiary Care Hospital

Kesavan¹,

RG²,

MATHEW³

et al. 2022

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The objective of the study was to analyze the pattern and risk factors of adverse drug reactions (ADR) in a tertiary care hospital. Methods: In this retrospective study, all the suspected ADRs reported to ADR monitoring center were analyzed for the demographic details, its temporal association, status of recovery, seriousness and outcome of reaction, details of the suspected and concomitant medications. Data on various predisposing factors responsible for an ADR, such as presence of co-morbidities, use of Fixed Dose Combinations (FDC), improper monitoring, presence of drug interactions, and presence of polypharmacy were also collected. Descriptive statistics and Chi-square were used for data analysis. A p value of <0.05 was taken as level of significance. Results: Out of the total 233ADRs, 48.9% were reported among geriatric patients. The study showed a female preponderance with 51.9%. The highest number of ADRs was reported from the therapeutic class of antimicrobials 18.9%. The skin and appendages constituted the most common organ system affected with 33.5%. Out of 106 serious ADRs, majority required prolonged hospitalization 62.3%. About 78.1 % of reactions were found to be predictable and 72.5% preventable. A positive association was found between ADR and co-exiting co-morbidity (60%), polypharmacy (66.5%), and use of FDC (18.45%). ADRs secondary to inadequate monitoring was 7.7% and those due to drug-drug interaction was 6.5%. Conclusion: Female population, age >60 years, and presence of concomitant co-morbidities were the patient related risk factors and polypharmacy, drug-drug interactions, and inadequate monitoring were the drug related risk factors for development of ADRs.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An Analysis of the Pattern and the Risk Factors of Adverse Drug Reactions at a Tertiary Care Hospital

Kesavan¹,

RG²,

MATHEW³

et al. 2022

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…Mounting studies published in KSA showed that antibiotics are the most frequent cause of ADRs [ 15 , 16 ]. However, the majority of the data are analyzed based on the hospital medical records and from ADR reports submitted to the Saudi Food and drug authority (SFDA), but reports from tertiary healthcare centers with respect to antibiotic-associated ADR are very scarce.…”

Section: Discussionmentioning

confidence: 99%

Antibiotics-Related Adverse Drug Reaction in a Tertiary Hospital in Saudi Arabia: A Cohort, Retrospective Study

Bakri¹,

Jaly²

2023

Cureus

View full text Add to dashboard Cite

Introduction: Adverse drug reactions (ADR) are caused by a wide range of drugs including antibiotics. Currently, the prevalence and pattern of antibiotic-related ADR in Saudi Arabia are not well reported. The present study aimed to evaluate the ADR pattern caused by antibiotics in a tertiary healthcare center. Methods: This was a retrospective study conducted on 85 patients admitted to tertiary care hospital medical wards during the period from 2015 to 2019. The following data such as patient demographics (age, gender, weight, height), reason for admission, number of antibiotics use, comorbid condition, antibiotic(s) involved in ADR, classification of ADR, and type of ADR were recorded. Naranjo’s scale was used to measure the probability of ADR. Results: Among the 85 patients, the most frequent type of antibiotic was cephalosporins in 36.47%, followed by penicillins in 31.76% of the patients. The major type of ADR was rash (52.95%), followed by anaphylaxis reactions (10.59%) of the patients. Based on the Naranjo scale, the ADR was possible in 80% and probable in 18.82% of the cases. The presence of medical conditions displayed a significant association with the development of rashes (p=0.03). In addition, the female gender (p=0.009) and the presence of medical conditions (p=0.03) showed significant association with the development of anaphylaxis. Conclusion: Cephalosporin and penicillins were the most common antibiotics responsible for ADR, and the rash was the most common ADR.

show abstract

Ritonavir: 25 Years’ Experience of Concomitant Medication Management. A Narrative Review

Quercia,

Di Perri,

Pein

et al. 2024

Infect Dis Ther

View full text Add to dashboard Cite

The evaluation of adverse drug reactions in Saudi Arabia: A retrospective observational study

Cited by 4 publications

References 27 publications

An Analysis of the Pattern and the Risk Factors of Adverse Drug Reactions at a Tertiary Care Hospital

An Analysis of the Pattern and the Risk Factors of Adverse Drug Reactions at a Tertiary Care Hospital

Antibiotics-Related Adverse Drug Reaction in a Tertiary Hospital in Saudi Arabia: A Cohort, Retrospective Study

Ritonavir: 25 Years’ Experience of Concomitant Medication Management. A Narrative Review

Contact Info

Product

Resources

About