The Evaluation Incidence and Risk Factors of Mortality among Patients with End Stage Renal Disease in Southeast Turkey

Şit, Dede; Kadiroglu, Ali Kemal; Kayabaşı, Hasan; Kara, İsmail Hamdi; Yılmaz, Zülfükar; Yılmaz, Mehmet Emin

doi:10.1080/08860220701741965

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…It’s suggested to measure hemoglobin in patients with impaired renal function to identify those with a higher risk of having or developing anemia, and to assess renal function using a simple and reliable formula based on their mutual relationship, which accords with our study . Furthermore, anemia and hypoalbuminemia were associated with increased risk of morbidity and mortality in end‐stage renal disease, which seems to fit in with our findings.…”

Section: Discussionsupporting

confidence: 90%

Clinical features and potential relevant factors of renal involvement in primary Sjögren’s syndrome

Luo

et al. 2018

Int J of Rheum Dis

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Objective To investigate distinct features of renal involvement in patients with primary Sjögren’s syndrome (pSS) and to identify potential factors associated with renal involvement. Methods Four hundred and thrity‐four pSS patients from the Rheumatology Department of the First Affiliated Hospital of Wenzhou Medical University from 2013 to 2017 were included in a cross‐sectional study. Patients with renal involvement were compared with their age‐ and gender‐matched controls (pSS without renal involvement). Demographic, clinical, histological, nephritic, immunological features of renal involvement in pSS were systematically analyzed. Possible factors related to renal involvement were identified using multivariate logistic regression analyses. Results One hundred and ninety‐two pSS patients (88.48%) with renal involvement were women with mean age of nearly 58 years and mean disease duration of above 4 years. Clinical manifestation, serologic and immunological features and renal biopsy class of the pSS patients with renal involvement were presented. By multivariate analyses, xerophthalmia, histological positivity for lower salivary gland biopsy (LSGB), anti‐SSA/Ro52‐positive, reduced complement 3 (C3) levels, hypoalbuminemia and anemia retained significant association with renal involvement in pSS (all P < 0.05). Conclusion In addition to LSGB pattern, anti‐SSA/Ro52‐positivity, reduced C3 levels, hypoalbuminemia and anemia, also indicate significant association with renal involvement in pSS. Therefore, early vigilance is required for patients with these clinical manifestations.

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Section: Discussionsupporting

confidence: 90%

Clinical features and potential relevant factors of renal involvement in primary Sjögren’s syndrome

Luo

et al. 2018

Int J of Rheum Dis

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“…1 Risk of CVD is 3.5-50 times higher in patients undergoing renal replacement therapy than in general population. 2,3 Augmentation in the risk of CVD in patients with ESRD is not only related to traditional risk factors, even when the traditional risk factors are fixed, but also related to untraditional and uremia-specific risk factors such as hypertension secondary to chronic hypervolemia, anemia, disorders of calcium-phosphorus (Ca-P) metabolism, hypercatabolism, hyperhomocysteinemia, and chronic microinflammation subsequent to oxidative stress (OS). 4 OS is described as dominance of pro-oxidants to antioxidant systems and plays an important role in the development of systemic diseases and related complications.…”

Section: Introductionmentioning

confidence: 99%

Parameters of oxidative stress and echocardiographic indexes in patients on dialysis therapy

Kayabaşı

Şit²,

Atay

et al. 2010

Renal Failure

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Aim: Quantity of oxidative stress (OS) is enhanced in every stage of chronic renal failure (CRF). OS and its effects on echocardiographic indexes in patients on hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) were evaluated. Materials and methods: Thirty-nine patients on CAPD, 32 patients on HD, and 30 healthy individuals with similar demographic features were included. Patients with diabetes mellitus and chronic inflammatory diseases were excluded. Blood samples were collected to examine hematological and biochemical parameters and levels of malonyldialdehyde (MDA), glutathione peroxidase (GSH-px), and superoxide dismutase (SOD) after a 12-hour fasting period in the middle of dialysis week. OS parameters were compared with ejection fraction (EF), interventricular septum diameter (IVSd), left ventricular posterior wall diameter (LVPWd), and left atrium diameter (LAd) determined in M-mod echocardiographic examination. Results: No significant difference was observed between MDA and GSH-px levels of patients and control group; however, SOD levels of patients group were significantly lower (p < 0.0001). SOD levels of patients on HD were lower than that of patients on CAPD (p = 0.039). No correlation was determined between antioxidants and cardiac indexes. Conclusion: SOD levels decreased significantly especially in patients on HD, and it was observed that lower levels of SOD would lead to OS in patients on HD and CAPD when compared to healthy individuals; MDA levels were independently influenced from EF.

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Is there an association between elevated or low serum levels of phosphorus, parathyroid hormone, and calcium and mortality in patients with end stage renal disease? A meta-analysis

et al. 2013

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BackgroundBiochemical markers of altered mineral metabolism have been associated with increased mortality in end stage renal disease patients. Several studies have demonstrated non-linear (U-shaped or J-shaped) associations between these minerals and mortality, though many researchers have assumed linear relationships in their statistical modeling. This analysis synthesizes the non-linear relationships across studies.MethodsWe updated a prior systematic review through 2010. Studies included adults receiving dialysis and reported categorical data for calcium, phosphorus, and/or parathyroid hormone (PTH) together with all-cause mortality. We performed 2 separate meta-analyses to compare higher-than-referent levels vs referent and lower-than-referent levels vs referent levels.ResultsA literature review showed that when a linear relationship between the minerals and mortality was assumed, the estimated associations were more likely to be smaller or non-significant compared to non-linear models. In the meta-analyses, higher-than-referent levels of phosphorus (4 studies, RR = 1.20, 95% CI = 1.15-1.25), calcium (3 studies, RR = 1.10, 95% CI = 1.05-1.14), and PTH (5 studies, RR = 1.11, 95% CI = 1.07-1.16) were significantly associated with increased mortality. Although no significant associations between relatively low phosphorus or PTH and mortality were observed, a protective effect was observed for lower-than-referent calcium (RR = 0.86, 95% CI = 0.83-0.89).ConclusionsHigher-than-referent levels of PTH, calcium, and phosphorus in dialysis patients were associated with increased mortality risk in a selection of observational studies suitable for meta-analysis of non-linear relationships. Findings were less consistent for lower-than-referent values. Future analyses should incorporate the non-linear relationships between the minerals and mortality to obtain accurate effect estimates.

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The Evaluation Incidence and Risk Factors of Mortality among Patients with End Stage Renal Disease in Southeast Turkey

Abstract: CVD are the most important preventable causes of morbidity and mortality in all stages of chronic kidney disease. Taking precaution against CVD and the associated complications will provide a positive contribution in reducing morbidity and mortality among ESRD patients.

Cited by 3 publications

References 22 publications

Clinical features and potential relevant factors of renal involvement in primary Sjögren’s syndrome

Clinical features and potential relevant factors of renal involvement in primary Sjögren’s syndrome

Parameters of oxidative stress and echocardiographic indexes in patients on dialysis therapy

Is there an association between elevated or low serum levels of phosphorus, parathyroid hormone, and calcium and mortality in patients with end stage renal disease? A meta-analysis

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