2006
DOI: 10.3109/2000-1967-026
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The Evaluation and Treatment of Therapy-Resistant Enuresis: A Review

Abstract: Children with enuresis that neither responds to the alarm or to desmopressin medication usually have nocturnal detrusor over-activity combined with high arousal thresholds as a cause for their bedwetting.The evaluation of these children is focused on 1) excluding underlying pathology such as kidney disease, urinary tract infection or neurogenic bladder, 2) looking for concomitant day-time bladder problems or constipation, and 3) detecting possible reasons for failure of alarm treatment. A bladder diary is esse… Show more

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Cited by 31 publications
(16 citation statements)
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References 27 publications
(28 reference statements)
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“…Los niños con enuresis tienen más probabilidades de desarrollar sintomatología de la esfera psicológica, generalmente subclínica, como disminución de autoestima, timidez, irritabilidad y aislamiento social (6)(7)(8).…”
Section: Introductionunclassified
“…Los niños con enuresis tienen más probabilidades de desarrollar sintomatología de la esfera psicológica, generalmente subclínica, como disminución de autoestima, timidez, irritabilidad y aislamiento social (6)(7)(8).…”
Section: Introductionunclassified
“…Therefore, the synthetic AVP analogue desmopressin is widely used to treat children with MNE [6]. Its antidiuretic action results from an increased renal reabsorption of water, leading to a reduced volume and more concentrated urine.…”
Section: Introductionmentioning
confidence: 99%
“…If these causes can be ruled out, the most commonly recommended first-line therapies are pharmacological treatment with desamino-arginine vasopressin (dDAVP) and ⁄ or alarm therapy with alarm devices, which both constitute treatments of first choice (2). However, because of its side effect profile, the initiation of this treatment should be limited to specialized centres (2,6). If neither pharmacological nor alarm treatment is efficient in the older child with relevant psychosocial impact, an individual therapeutic trial with imipramine can be undertaken.…”
Section: Introductionmentioning
confidence: 99%