The Evaluation and Management of Toxic Shock Syndrome in the Emergency Department: A Review of the Literature

Gottlieb, Michael; Long, Brit; Koyfman, Alexander

doi:10.1016/j.jemermed.2017.12.048

Cited by 73 publications

(56 citation statements)

References 109 publications

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“…It is of cumbersome signifi cance to diagnose and treat STSS timely 14 . The presence of STSS in adults sometimes reveals some condition or disease that disturbs the host's immune system.…”

Section: Resultsmentioning

confidence: 99%

“…Depending on cycle, STSS is historically divided into menstrual and non-menstrual form. The menstrual form of STSS is associated with vaginal tampon use, while the non-menstrual form can be caused by focal infections, burns, soft tissue injuries, postsurgical and postpartum wounds and infections 6,13,14 . The prevalence of antibodies against TSST-1 is over 90% in adults, but in children is signifi cantly lower 12,15 .…”

Section: Discussionmentioning

confidence: 99%

“…The patients should be aggressively managed according to the current sepsis guidelines 12,17 . Antibiotics should include a penicillinase-resistant penicillins, cephalosporins, or vancomycin along with either clindamycin or linezolid 14 . Despite antimicrobial and other resuscitation therapy, the overall mortality rates are high.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

An old fox is trapped: The staphylococcal toxic shock syndrome in male adult: Case report

Gluvić¹,

Mitrović²,

Lačković³

et al. 2018

Materia medica

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1 Kliničko bolnički centar Zemun, Služba endokrinologije, dijabetesa i internističke intenzivne nege, Medicinski fakultet, Univerzitet u Beogradu, Srbija 2 Kliničko bolnički centar Zemun, Služba gastroenterologije sa hepatologije, Medicinski fakultet, Univerzitet u Beogradu, Srbija 3 Institut za nuklearne nauke "Vinča", Laboratorija za radiobiologiju i molekularnu genetiku, Univerzitet u Beogradu, Srbija ApstraktStafilokokni toksični šok sindrom (STŠS) se obično javlja kod novorođenčadi i dece, ali se povremeno može javiti i kod odraslih. U tom slučaju, obično ukazuje na disfunkciju imunog sistema. Prikazan je slučaj kritično-obolelog odraslog muškarca sa STŠS i simptomima i znacima životno-ugrožavajuće sistemske infekcije (hemodinamska nestabilnost, akutna insuficijencija bubrega, konfuzija). Nakon završenog lečenja (anti-stafilokoni antibiotici, hemodijaliza, vazopresori, suportivna i simptomatska terapija), postignuta je potpuna remisija kod obolelog. Pravovremena dijagnostika i adekvatan tretman je glavno uporište u lečenju STŠS kod odraslih.Ključne reči: vezikule, stafi lokoke, toksični šok. AbstractStaphylococcal toxic shock syndrome (STSS) is typically detected in newborns and children but can be seen in adults occasionally. In such a case, it points out usually on some immune system dysfunction. We present a case of a critically-ill adult male with STSS and symptoms and signs of serious systemic infection (hemodynamic instability, acute renal failure, mental confusion). After the completion of applied treatment (antistaphylococcal antimicrobials, hemodialysis, vasopressor, supportive, and symptomatic therapy), complete restoration of presented patients' derangements was achieved. Timely diagnosis and appropriate treatment is the mainstay in the management of STSS in adults.

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“…It is of cumbersome signifi cance to diagnose and treat STSS timely 14 . The presence of STSS in adults sometimes reveals some condition or disease that disturbs the host's immune system.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

An old fox is trapped: The staphylococcal toxic shock syndrome in male adult: Case report

Gluvić¹,

Mitrović²,

Lačković³

et al. 2018

Materia medica

View full text Add to dashboard Cite

show abstract

“…Given the potential for Methicillin-resistant Staphylococcus aureus (MRSA), vancomycin, or linezolid should be considered in cases of suspected staphylococcal TSS. 51 Linezolid has the added benefit of reducing exotoxin release, including TSST-1. 4 , 52 In cases of suspected streptococcal TSS, penicillin G remains an antibiotic of choice.…”

Section: Discussionmentioning

confidence: 99%

“… 4 , 49 , 53 In addition to linezolid, clindamycin, erythromycin, rifampin, and fluoroquinolones have all been demonstrated to reduce bacterial exotoxin release by up to 90%. 51 Clindamycin is a common choice in combination with vancomycin or penicillin G. 4 , 51 …”

Section: Discussionmentioning

confidence: 99%