The Evaluation and Comparison of Oxidative Stress in Hemorrhagic and Ischemic Stroke

Shoeibi, Ali; Razmi, Nilufar; Juibary, Ali Ghabeli; Hashemy, Seyed Isaac

doi:10.29252/nirp.cjns.3.11.206

Cited by 7 publications

(5 citation statements)

References 30 publications

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“…This is in agreement with the results of Mendioroz et al [19] who stated that 59.9% of patients (on admission) showed NIHSS score (16)(17)(18)(19)(20). Also, Mansour et al [20] recorded in a cohort study that their patients NIHSS median value at 24 h was 22 (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) and at 72 h was 20 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), otherwise Soliman et al [21] reported that 61.7% of their patients show NIHSS moderate score (5)(6)(7)(8)(9)(10)…”

Section: Discussionsupporting

confidence: 88%

“…In the current study, concerning relationship between MDA and National Institutes of Health Stroke Scale (NIHSS), we found no significant relation between level of MDA and stroke severity when assessed by NIHSS score on admission. Our result goes in hand with Shoeibi et al [25] who reported that there was a non-significant relation between NIHSS and MDA (p = 0.791). Also, Ferhat et al [26] who reported that there were no significant relations between the NIHSS value and oxidative stress biomarkers.…”

Section: Discussionsupporting

confidence: 49%

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The relationship between oxidative stress and acute ischemic stroke severity and functional outcome

ElSayed

Abd-Elgawad

Mesallam

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

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Background: Cerebral ischemia initiates an oxidative stress response in the brain which is a composite process that involves many oxidative stress biomarkers. High levels of malondialdehyde (MDA) in patients with acute ischemic stroke had been found. The evaluation of oxidative stress in the acute stage may contribute to improve the post ischemic stroke outcome. Objective: The aim of the current study to assess MDA level, as an oxidative stress biomarker, in acute ischemic stroke on admission and its relation with stroke severity on admission and also, its relation with three months shortterm outcome. Methods: Forty-two patients (20 males and 22 females) with acute ischemic stroke were prospectively enrolled in follow-up cohort study. Serum MDA was measured within 24 h after admission. We studied the relationship between MDA and stroke severity and functional outcome after 3 months assessed by National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) respectively. Results: Serum MDA levels correlated significantly with clinical short-term stroke outcome after 3 months (p < 0.001). Conclusion(s): These data provide evidence that the MDA (an oxidative stress biomarker) may be used as predictor for functional outcome in acute ischemic stroke.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 49%

The relationship between oxidative stress and acute ischemic stroke severity and functional outcome

ElSayed

Abd-Elgawad

Mesallam

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

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“…The elevated tRNA derivative values in both ischemic and hemorrhagic stroke patients remained high for a week, suggesting that subsequent brain damage, following the initial event, such as excitotoxicity [16], oxidative stress [17], and inflammation continued around the lesions [18]. Postischemic inflammation persists for several weeks [19].…”

Section: Discussionmentioning

confidence: 99%

“…tiR-NA [20] is abnormally expressed in various human diseases, not only stroke [21]. RNA derivatives in serum are closely related to aging and calorie intake [17]. Any comorbidities and general condition should be considered.…”

Section: Limitationsmentioning

confidence: 99%

Prediction of Functional Outcome in Patients with Acute Stroke by Measuring tRNA Derivatives

et al. 2020

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Background and Purpose: Transfer RNA (tRNA) is a noncoding RNA that delivers amino acids to ribosomes for protein synthesis. tRNA is also involved in cell stress response programs. Oxidative stress induces direct conformational change in tRNA structure that promotes subsequent tRNA fragmentation. Using an antibody against tRNA-specific modified nucleoside 1-methyladenosine (m1A), we can detect tRNA derivatives such as conformationally changed tRNA, tRNA-derived fragments, and mononucleotide-free m1A. Based on these findings, tRNA derivatives may have potential as an early tissue damage marker. The purpose of this study was to investigate the plasma tRNA derivatives in stroke patients to clarify whether tRNA derivatives in the acute phase can detect early brain damage and then predict the functional outcome. Methods: Patients (75 patients with ischemic and 66 with hemorrhagic stroke) and 22 healthy volunteers were prospectively enrolled for this study between November 2016 and February 2019. Plasma samples were collected within 24 h and at 1 day, 7 days, and 30 days from the onset. Plasma tRNA derivative concentrations were measured by ELISA kit using the anti-m1A antibody. Results: The plasma tRNA derivative level on admission was significantly increased in both ischemic (mean ± standard error, 232.2 ± 33.1 ng/mL) and hemorrhagic stroke patients (212 ± 23.4 ng/mL) compared to the healthy volunteers (86.0 ± 7.9 ng/mL) (p = 0.00042 and p = 0.00018, respectively). The infarction size (r = 0.445, p = 0.00018) and hematoma volumes (r = 0.33, p = 0.0072) were also significantly correlated with tRNA derivatives. The concentrations of tRNA derivatives were associated with poor functional outcome (Modified Rankin Scale score 3–6 at 30 days from the onset) in patients with ischemic stroke at 7 days after onset (p = 0.020). Conclusions: Stress-induced tRNA derivatives can detect brain tissue damage, predicting functional outcome in patients with ischemic stroke.

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“…21 Hamzei Moqaddam, et al study shows that opium abuse can increase plasma fibrinogen which can independently cause and progress atherosclerosis in coronary, peripheral, and brain vessels. 9 Its effect on oxidative stress which play role in stroke 22 is not yet established. It is predicted that opium can have the same damaging effect on brain vessels similar to coronary vessels.…”

Section: Discussionmentioning

confidence: 99%

Cerebral hemodynamic abnormalities of patients with ischemic stroke who are opium addicted: A study by transcranial doppler ultrasonography

Moadabi

Saberi

Hoseini

et al. 2019

CJN

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Background: Ischemic stroke as the major cause of mortality and morbidity worldwide has different risk factors. One of its modifiable risk factors is opium addiction whose role is not clear yet. This study aimed at assessing the hemodynamic parameters in ischemic stroke patients addicted to opium using transcranial Doppler (TCD) ultrasonography and comparing them with non-addicted patients. Methods: This comparative cross-sectional study was conducted in an academic hospital in the north of Iran in 2016. All the patients diagnosed as ischemic stroke underwent cerebrovascular ultrasound in the first 4 days of symptoms onset. Frequency of hemodynamic abnormalities confirmed by pulsatility index (PI) and mean flow velocity (MFV) were determined and compared between the two groups. The data were analyzed by chi-square test, t-test, and multiple logistic regression models using SPSS software. Results: A total of 353 patients with ischemic stroke (92 addicted and 261 non-addicted patients) were enrolled in the study. Univariate analysis indicated that the PI and MFV differences were statistically significant between two groups of addicted and nonaddicted patients (P = 0.0001). By multivariate logistic regression model, the age [odds ratio (OR) = 1.143], diabetes mellitus (DM) (OR = 3.875), hypertension (HTN) (OR = 2.557), and opium usage (OR = 9.615) had influence on PI and only opium usage (OR = 3.246) had influence on MFV. Conclusion: Opium usage affects the cerebral hemodynamic parameters and increases the chance of having abnormal PI as ten-fold and abnormal MFV as three-fold.

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The Evaluation and Comparison of Oxidative Stress in Hemorrhagic and Ischemic Stroke

Cited by 7 publications

References 30 publications

The relationship between oxidative stress and acute ischemic stroke severity and functional outcome

The relationship between oxidative stress and acute ischemic stroke severity and functional outcome

Prediction of Functional Outcome in Patients with Acute Stroke by Measuring tRNA Derivatives

Cerebral hemodynamic abnormalities of patients with ischemic stroke who are opium addicted: A study by transcranial doppler ultrasonography

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