The EurValve model execution environment

Abstract

The goal of this paper is to present a dedicated high-performance computing (HPC) infrastructure which is used in the development of a so-called reduced-order model (ROM) for simulating the outcomes of interventional procedures which are contemplated in the treatment of valvular heart conditions. Following a brief introduction to the problem, the paper presents the design of a model execution environment, in which representative cases can be simulated and the parameters of the ROM fine-tuned to enable subsequent deployment of a decision support system without further need for HPC. The presentation of the system is followed by information concerning its use in processing specific patient cases in the context of the EurValve international collaboration.

Computational biomedicine. Part II: organs and systems

“…With necessary legal protections of patient data preventing its export to more powerful machines, one approach to overcome this is to develop reduced-order models based on pre-simulated data that can be run cheaply by clinicians. Bubak et al [26] present an infrastructure for conducting detailed fluid dynamics simulations of valvular heart conditions to generate the data necessary to develop a suitable reduced-order model and discuss the technical considerations surrounding this. They report that 73% of surveyed clinicians felt that the information generated from their framework was useful and would aid clinical management.…”