The European Registry on Cushing's syndrome: 2-year experience. Baseline demographic and clinical characteristics

Valassi, Elena; Santos, Alicia; Yaneva, Maria; Tóth, Miklós; Strasburger, Christian J.; Chanson, Philippe; Wass, John; Chabre, Olivier; Pfeifer, Marija; Feelders, Richard A; Tsagarakis, Stylianos; Trainer, Peter J; Franz, Holger; Zopf, Kathrin; Zacharieva, Sabina; Lamberts, Steven W. J.; Tabarin, Antoine; Webb, Susan M.

doi:10.1530/eje-11-0272

Cited by 324 publications

(326 citation statements)

References 31 publications

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“…Cushing syndrome (CS) is a clinical state of prolonged exposure to inappropriately high levels of exogenous or endogenous glucocorticoids and is associated with significant morbidity and mortality (1)(2)(3)(4)(5). Surgical resection of the causal tumor(s) remains the first-line therapy for endogenous CS.…”

Section: Introductionmentioning

confidence: 99%

Association Between Mifepristone Dose, Efficacy, and Tolerability in Patients With Cushing Syndrome

Yuen

Williams

Kushner³

et al. 2015

Endocrine Practice

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Section: Introductionmentioning

confidence: 99%

Association Between Mifepristone Dose, Efficacy, and Tolerability in Patients With Cushing Syndrome

Yuen

Williams

Kushner³

et al. 2015

Endocrine Practice

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“…The diagnostic latency of Cushing's syndrome (CS) in general is reported with a median of 2 years in two recent studies, but studies which focus exclusively on the latency between symptom occurrence and diagnosis of pituitary-dependent CD are lacking so far (5,6). Also, no data exist which elucidate the reasons for the long diagnostic process of patients with CD or CS.…”

Section: Introductionmentioning

confidence: 99%

From first symptoms to final diagnosis of Cushing's disease: experiences of 176 patients

Kreitschmann-Andermahr¹,

Psaras²,

Tsiogka³

et al. 2015

European Journal of Endocrinology

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Objective: To obtain structured information on the diagnostic delay in patients with Cushing's disease (CD) from the patients perspective to provide leverage points for earlier diagnosis. Design: The study includes 176 patients with ACTH-dependent CD who had received pituitary surgery completed a self-developed questionnaire on their symptomatology before the illness was diagnosed, the course and length of the diagnostic process, and the role of the involved health care professionals. Methods: Data were analyzed statistically. Answers in free text options were categorized and counted. Results: The overall diagnostic process took 3.8G4.8 years (median 2 years), during which 4.6G3.8 (1-30) physicians were consulted, most frequently the family physician (FP; 83.0%). The presented symptoms were various and often vague, e.g. 'poor general condition' (at FPs), or very common in the field of the visited specialist (i.e. 'skin changes' at dermatologists). Women recognized the first CD symptoms themselves significantly more frequently than men, whereas physicians recognized CD symptoms significantly more frequently in males. Conclusion: A clear difficulty of diagnosing CD seems that patients describe isolated symptoms to the FP or the respective specialists according to their fields of specialization. As FPs are contacted most frequently, they should be trained to recognize the broad spectrum of CD symptoms, especially in female patients with weight gain, and initiate endocrinological referral.

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“…These pathognomonic signs can be detected by face classification software and could hypothetically be used for early diagnosis. Recent studies have found that CS is currently diagnosed with a latency of about 2-6 years (1,2). This may partly be due to an overlap of clinical features with the more common metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic use of facial image analysis software in endocrine and genetic disorders: review, current results and future perspectives

Kosilek

Frohner

Würtz

et al. 2015

European Journal of Endocrinology

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Cushing's syndrome (CS) and acromegaly are endocrine diseases that are currently diagnosed with a delay of several years from disease onset. Novel diagnostic approaches and increased awareness among physicians are needed. Face classification technology has recently been introduced as a promising diagnostic tool for CS and acromegaly in pilot studies. It has also been used to classify various genetic syndromes using regular facial photographs. The authors provide a basic explanation of the technology, review available literature regarding its use in a medical setting, and discuss possible future developments. The method the authors have employed in previous studies uses standardized frontal and profile facial photographs for classification. Image analysis is based on applying mathematical functions evaluating geometry and image texture to a grid of nodes semi-automatically placed on relevant facial structures, yielding a binary classification result. Ongoing research focuses on improving diagnostic algorithms of this method and bringing it closer to clinical use. Regarding future perspectives, the authors propose an online interface that facilitates submission of patient data for analysis and retrieval of results as a possible model for clinical application.

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The European Registry on Cushing's syndrome: 2-year experience. Baseline demographic and clinical characteristics

Cited by 324 publications

References 31 publications

Association Between Mifepristone Dose, Efficacy, and Tolerability in Patients With Cushing Syndrome

Association Between Mifepristone Dose, Efficacy, and Tolerability in Patients With Cushing Syndrome

From first symptoms to final diagnosis of Cushing's disease: experiences of 176 patients

Diagnostic use of facial image analysis software in endocrine and genetic disorders: review, current results and future perspectives

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