The European Psychiatric Association (EPA) guidance on suicide treatment and prevention

Wasserman, Danuta; Rihmer, Zoltán; Rujescu, Dan; Sarchiapone, Marco; Sokolowski, Marcus; Titelman, David; Zalsman, Gil; Zemishlany, Zvi; Carli, Vladimir

doi:10.1016/j.eurpsy.2011.06.003

Cited by 296 publications

(231 citation statements)

References 166 publications

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“…El desarrollo y la implementación de intervenciones efectivas y basadas en la evidencia es fundamental a la hora de reducir los índices de suicidio o conductas relacionadas con el mismo (Brown & Jager-Hyman, 2014;Wasserman et al, 2012). Siguiendo esta línea, la investigación realizada se propuso indagar la producción empírica sobre el suicidio en Sudamérica, especialmente en Argentina.…”

Section: Discussionunclassified

El lugar de la psicología en las investigaciones empíricas del suicidio en Argentina: Un estudio bibliométrico

Flores-Kanter¹

2017

Interd

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RESuMEnEl suicidio constituye un problema de salud pública que tiene un gran impacto económico, social y psicológico a nivel mundial. Cada año se estima que mueren cerca de un millón de personas en todo el mundo debido al suicidio. De lo anterior se desprende la importancia de contar con investigaciones empíricas que sustenten todo tipo de accionar en la problemática del suicidio, desde políticas en salud pública hasta tratamientos psicológicos. Dada la relevancia del tema, el estudio bibliométrico realizado tuvo como principal objetivo verificar la producción empírica sobre el suicidio en Argentina, haciendo especial énfasis en el lugar de la Psicología en dicha producción. Sintetizando, los resultados permiten concluir que la producción empírica sobre el suicidio en los principales países de Sudamérica es muy baja; más aún si se considera solamente a Argentina. Otra conclusión importante tiene que ver con la menor implicancia de la ciencia psicológica en el abordaje empírico del suicidio, comparando los aportes desde un enfoque médico. Estas conclusiones invitan a reflexionar sobre la necesidad de un mayor abordaje empírico del suicidio en la región, y particularmente en Argentina.Palabras clave: Argentina; Estudio bibliomé-trico; Psicología basada en la evidencia; Suicidio; Investigaciones; Sudamérica. abSTRaCTSuicide is a major problem of public health lead ing to great economic, social, and psychol ogical costs worldwide. Around one million people die every year on the world due to suicide. Furthermore, suicide is responsible for half of violent deaths worldwide exceeding even the combination of deaths due to war or homicide. Taking into account the above, researchers around the world recommended concerted efforts to generate actions, research, and investigation with the objective of reduce risk to suicide. Therefore, evidence from empirical research supporting public health policies and psychological treatments is needed. The present article introduces a biblio metric study aim ed to examine the state of empirical research on suicide in Argentina, and specially the amount of psychological empirical research. Specifically, research methodology consists of the following aspects: As regards the criteria of inclusion / exclusion of articles, the search focused on the detection of empirical suicide articles. In this sense, the main criterion for inclusion in the analysis was based on studies that have been published or were being published in scientific journals. For the aforementioned reasons, they were excluded from this study theoretical article, books, book chapters, theses, and confer ence presentation. Also, those articles that used the term suicide to address problems outside the addressed (e.g., Suicide Gene Therapy) were ex-

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Section: Discussionunclassified

El lugar de la psicología en las investigaciones empíricas del suicidio en Argentina: Un estudio bibliométrico

Flores-Kanter¹

2017

Interd

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“…The evidence supports a clear advantage of clozapine therapy in terms of reduced mortality over other antipsychotic agents including FGAs, risperidone and quetiapine [39][40][41][42].…”

Section: Clozapine Effectiveness On Mortalitymentioning

confidence: 92%

“…It has also been suggested that earlier use (as a second line agent) can be recommended in individuals with persistent hostility/aggressive behaviour [47] and suicidalilty [39][40][41][42]. In fact the indication for recurrent suicidal behavior has been officially approved by the FDA [48].…”

Section: Discussionmentioning

confidence: 99%

“…Concerns over other adverse effects, which include weight gain, hyperglycemia, seizures, tachycardia, myocarditis and neuromalignant syndrome [61], can affect the decision making process and even less severe side effects (sedation, constipation, nocturnal hypersalivation) might result in patients' resistance to try this medication [42,62]. Clozapine has shown, however, a definite advantage in reversing tardive dyskinesia [13,17,34,58].…”

Section: Discussionmentioning

confidence: 99%

“…During phase 3 of the CATIE study, 51% of patients had previously discontinued medications due to ineffective therapeutic response, but only 11% of patients were offered clozapine during phase 3. Studies of clozapine utilization have shown that adherence to guidelines has been poor through the years with clozapine been consistently underutilized in the US, UK, Canada, New Zealand and Australia [9,[21][22][23][24][25][26][42][43][44][45][46]. In a study of the Veterans Health Administration, only 2% of patients affected by schizophrenia were receiving clozapine [22].…”

Section: Clozapine Prescribing Trendsmentioning

confidence: 99%

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A Case of Drug-Induced Acute Dyskinesia Treated with Korean Medicine

Lee¹,

Shin²,

Kim³

et al. 2017

J Int Korean Med

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Background: Clozapine effectiveness in the treatment of refractory schizophrenia has been sustained by published evidence in the last two decades, despite the introduction of safer options. Discussion: Current clinical practice guidelines have strongly recommended the use of clozapine in treatment-resistant schizophrenia, but prescribing trends do not appear to have followed such recommendations. Clozapine is still underutilized especially in patients at risk of suicide. It seems that physicians are hesitant in prescribing clozapine due to concerns about serious adverse effects. Recent reports have highlighted the need to inform health professionals about the benefits of treating patients with clozapine and have voiced concerns about the underutilization of clozapine especially in patients at risk of suicide. Summary: Guidelines and prescribing patterns reported in various countries worldwide are discussed. Suggestions on how to optimize clozapine utilization have been published but more efforts are needed to properly inform and support prescribers' practices.

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