The European Association for the Study of Diabetes

Increased DNA-Glycation in Type 2 Diabetic Patients: The Effect of Thiamine and Pyridoxine Therapy

“…In this respect, numerous studies have reported on the benefi cial eff ects of the derivatives of vitamins B 1 and B 6 which are both involved in the metabolism of carbonyl compounds ( La Selva et al, 1996 ;Booth et al, 1997 ;Pomero et al, 2001 ;Voziyan et al, 2002 ;Degenhardt et al, 2002 ;Amarnath et al, 2004 ;Thornalley et al, 2007 ;Nakamura et al, 2007 ). Importantly, the existence of a moderate defi ciency of vitamin B 1 in diabetic patients has been reported and an intake of 250-300 mg/day has been suggested at the thiamine symposium of the European Association of Study for Diabetes (EASD) ( Bloomgarden, 2005 ). In this study we primarily aimed to investigate whether the extent of glycation increases in DNA in diabetes mellitus and secondarily to observe the eff ects of vitamins B 1 and B 6 , on glycation in diabetic nephropathy patients.…”

“…The derivatives of vitamins B 1 and B 6 were reported to have inhibitory eff ects on protein glycation ( La Selva et al, 1996 ;Booth et al, 1997 ;Pomero et al, 2001 ;Degenhardt et al, 2002 ;Voziyan et al, 2002 ). Low plasma thiamine concentration has been reported to be prevalent in patients with type 1 and type 2 diabetes and a daily intake of 250-300 mg thiamine had been advised to the diabetic patients by EASD ( Bloomgarden, 2005 ).…”

Potential pharmacodynamic drug-drug interaction between concomitantly administered lisinopril and diclofenac sodium: a call for appropriate management in hypertensive osteoarthritic patients

“…Chronic infl ammation is an important risk factor involved in the pathophysiology of insulin resistance (30,37) . Chronic infl ammation is an important risk factor involved in the pathophysiology of insulin resistance (30,37) .…”

“…At the renal level, inhibition of PGs results in a drop in the renal blood fl ow, with reduced GFR and a consequent increase in serum urea, and S cr with a decrease in CLCR (20,30,32) . This is due to hypoperfusion secondary to volume depletion from overaggressive diuresis, low cardiac output seen in heart failure, or both.…”