The eukaryotic Initiation Factor 6 (eIF6) regulates ecdysone biosynthesis by modulating translation inDrosophila

Abstract

22Increases in ribosomal proteins and initiation factors are often observed in tumours 23 and required during development. Haploinsufficient models have shown that such 24 elevation is essential for tumour growth. Models with increased gene dosage of 25 initiation factors, addressing the effects of their forced overexpression are lacking. 26The eukaryotic Initiation Factor 6 (eIF6) gene is amplified in some cancers and