The Ets Factor Etv1 Interacts with Tpit Protein for Pituitary Pro-opiomelanocortin (POMC) Gene Transcription

Budry, Lionel; Couture, Catherine; Balsalobre, Aurélio; Drouin, Jacques

doi:10.1074/jbc.m110.202788

Cited by 17 publications

(5 citation statements)

References 42 publications

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“…Actually, studies in zebrafish and mammals have shown that Pax7 has a crucial role in the formation of the pars intermedia or the intermediate lobe (Guner et al, 2008 ; Hosoyama et al, 2010 ). Particularly in mammals, Pax7 constitutes a specific marker of a postnatal progenitor cell subpopulation and the melanotrope cells of the intermediate lobe of the hypophysis (Hosoyama et al, 2010 ; Budry et al, 2011 ). The cells in the intermediate lobe of Xenopus represent melanotrope cells that control the process of background adaptation (Tuinhof et al, 1993 ), and their intense Pax7 expression throughout development suggests that this transcription factor is required to accomplish such an important functional role.…”

Section: Discussionmentioning

confidence: 99%

Regional expression of Pax7 in the brain of Xenopus laevis during embryonic and larval development

Bandín¹,

Morona²,

Moreno³

et al. 2013

Front. Neuroanat.

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Pax7 is a member of the highly conserved Pax gene family that is expressed in restricted zones of the central nervous system (CNS) during development, being involved in early brain regionalization and the maintenance of the regional identity. Using sensitive immunohistochemical techniques we have analyzed the spatiotemporal pattern of Pax7 expression in the brain of the anuran amphibian Xenopus laevis, during development. Pax7 expression was first detected in early embryos in the basal plate of prosomere 3, roof and alar plates of prosomere 1 and mesencephalon, and the alar plate of rhombomere 1. As development proceeded, Pax7 cells were observed in the hypothalamus close to the catecholaminergic population of the mammillary region. In the diencephalon, Pax7 was intensely expressed in a portion of the basal plate of prosomere 3, in the roof plate and in scattered cells of the thalamus in prosomere 2, throughout the roof of prosomere 1, and in the commissural and juxtacommissural domains of the pretectum. In the mesencephalon, Pax7 cells were localized in the optic tectum and, to a lesser extent, in the torus semicircularis. The rostral portion of the alar part of rhombomere 1, including the ventricular layer of the cerebellum, expressed Pax7 and, gradually, some of these dorsal cells were observed to populate ventrally the interpeduncular nucleus and the isthmus (rhombomere 0). Additionally, Pax7 positive cells were found in the ventricular zone of the ventral part of the alar plate along the rhombencephalon and the spinal cord. The findings show that the strongly conserved features of Pax7 expression through development shared by amniote vertebrates are also present in the anamniote amphibians as a common characteristic of the brain organization of tetrapods.

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Section: Discussionmentioning

confidence: 99%

Regional expression of Pax7 in the brain of Xenopus laevis during embryonic and larval development

Bandín¹,

Morona²,

Moreno³

et al. 2013

Front. Neuroanat.

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“…Limb buds collected from E11.5 mouse embryos (CD1) were washed with PBS and mechanically homogenized. Cell extracts and Co-IP incubations were performed as described previously (Budry et al, 2011). PVDF membranes (Millipore) were blotted with a homemade anti-Tbx4 antibody (1/1000) raised in rabbits using 100 μg MBP-tagged Tbx4 epitope (aa 1-72) and anti-Hoxc10 antibody (Santa Cruz, sc-33003, 1/200).…”

Section: Co-immunoprecipitationmentioning

confidence: 99%

Regulatory integration of Hox factor activity with Tbox factors in limb development

et al. 2018

Self Cite

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In tetrapods, , and Hox cluster genes are crucial for forelimb and hindlimb development and mutations in these genes are responsible for congenital limb defects. The molecular basis of their integrated mechanisms of action in the context of limb development remains poorly understood. We studied Tbx4 and Hoxc10 owing to their overlapping loss-of-function phenotypes and colocalized expression in mouse hindlimb buds. We report an extensive overlap between Tbx4 and Hoxc10 genome occupancy and their putative target genes. Tbx4 and Hoxc10 interact directly with each other, have the ability to bind to a previously unrecognized T-box-Hox composite DNA motif and show synergistic activity when acting on reporter genes. Pitx1, the master regulator for hindlimb specification, also shows extensive genomic colocalization with Tbx4 and Hoxc10. Genome occupancy by Tbx4 in hindlimb buds is similar to Tbx5 occupancy in forelimbs. By contrast, another Hox factor, Hoxd13, also interacts with Tbx4/Tbx5 but antagonizes Tbx4/Tbx5-dependent transcriptional activity. Collectively, the modulation of Tbx-dependent activity by Hox factors acting on common DNA targets may integrate different developmental processes for the balanced formation of proportionate limbs.

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“…For example, additional factors, both positive and negative, are implicated in driving POU1F1 expressing cells towards the specialization in production of GH, PRL or TSH 72 . The glucocorticoid and estrogen receptors and ETS factors are examples of factors that promote specialization 73-75 . In addition, components of the combinatorial code of factors can change during development in order to achieve the fully differentiated hormone-producing cell or to maintain it (reviewed in 76 ).…”

Section: The Role Of Signature Transcription Factors In Cell Specificmentioning

confidence: 99%

Pituitary Gland Development and Disease

Davis

Ellsworth

Millán

et al. 2013

Current Topics in Developmental Biology

107

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Many aspects of pituitary development have become better understood in the last two decades. The signaling pathways regulating pituitary growth and shape have emerged, and the balancing interactions between the pathways are now appreciated. Markers for multi-potent progenitor cells are being identified, and signature transcription factors have been discovered for most hormone producing cell types. We now realize that pulsatile hormone secretion involves a 3-D integration of cellular networks. About a dozen genes are known to cause pituitary hypoplasia when mutated due to their essential roles in pituitary development. Similarly, a few genes are known that predispose to familial endocrine neoplasia, and several genes mutated in sporadic pituitary adenomas are documented. In the next decade we anticipate gleaning a deeper appreciation of these processes at the molecular level, insight into the development of the hypophyseal portal blood system, and evolution of better therapeutics for congenital and acquired hormone deficiencies and for common craniopharyngiomas and pituitary adenomas.

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The Ets Factor Etv1 Interacts with Tpit Protein for Pituitary Pro-opiomelanocortin (POMC) Gene Transcription

Abstract: Pro-opiomelanocortin (POMC) is expressed in two lineages

Cited by 17 publications

References 42 publications

Regional expression of Pax7 in the brain of Xenopus laevis during embryonic and larval development

Regional expression of Pax7 in the brain of Xenopus laevis during embryonic and larval development

Regulatory integration of Hox factor activity with Tbox factors in limb development

Pituitary Gland Development and Disease

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