The etiology of poststroke-depression: a hypothesis involving HPA axis

Zhou, Lin; Wang, Tian; Yu, Yawen; Li, Mingan; Sun, Xiaohui; Song, Wenhao; Wang, Yunjie; Zhang, Ce; Fu, Fenghua

doi:10.1016/j.biopha.2022.113146

Cited by 26 publications

(11 citation statements)

References 108 publications

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“…PSD is the most common mental health problem, afflicting approximately 33% of stroke survivors, and PSD affects the recovery and quality of life of post-stroke patients ( Robinson and Jorge, 2016 ). A growing amount of research suggests a strong association between PSD and stroke, and that both physiology and psychology play an important role in PSD ( Zhou et al, 2022 ). Despite extensive efforts to study PSD, its pathogenesis is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Treatments to post-stroke depression, which is more effective to HAMD improvement? A network meta-analysis

et al. 2022

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Introduction: Post-stroke depression (PSD) is a common mental health problem after cerebrovascular accidents. There are several treatments that have been shown to be effective in treating post-stroke depression. However, it is not clear which treatment is more effective.Methods: In this meta-analysis, an appropriate search strategy was used to search eligible randomized controlled trials (RCTs) on different treatments to treat patients with Post-stroke depression published up to December 2021 from the CNKI, PubMed, and Cochrane Library. We assessed the mean difference or odds ratio between each treatment and placebo and summarized them as the average and 95% confidence interval (CI) by conducting Bayesian network meta-analyses.Results: By constructing a Bayesian network meta-analysis, we found that acupuncture combined with fluoxetine (vs placebo MD, −8.9; 95% CI, [−15, −2.9]) or paroxetine (vs placebo MD,—8.5; 95% CI, [−15, −2.5]) was the most effective for change in Hamilton depression scale (HAMD) at the end of the 4th week. For change in Hamilton depression scale at the end of the 8th week, rTMS combined with paroxetine (vs placebo MD, −13; 95% CI, [−17, −7.9]) had the greatest amount of change. The efficacy of medication combined with adjuvant therapy was also superior for the percentage of patients with Hamilton depression scale change over 50%.Discussion: The combination of antidepressants with adjuvant therapy may enhance the efficacy of antidepressants and achieve better results than antidepressant monotherapy in both Hamilton depression scale changes at the end of week 4 or 8 and 50% Hamilton depression scale improvement rate. Acupuncture combined with fluoxetine treatment was more effective in the treatment of post-stroke depression at week 4, while rTMS combined with paroxetine was more effective at week 8. Further research is needed to determine whether acupuncture combined with fluoxetine is better than rTMS combined with paroxetine for post-stroke depression at week 8.

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Section: Discussionmentioning

confidence: 99%

Treatments to post-stroke depression, which is more effective to HAMD improvement? A network meta-analysis

et al. 2022

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“…The major neuroendocrine stress response system involved in the regulation of mood, immunity, and metabolism because ofdysfunction of the hypothalamic-pituitary-adrenal (HPA) axis (Zhou et al, 2022). The hyperactivity of the HPA axis is one of the most consistent and signi cant biological ndings in major depressive psychiatry (Villa et al, 2018).…”

Section: Group 1: Study Of Risk Factors For Depression After Strokementioning

confidence: 99%

Bibliometric analysis of global research trends in post-stroke depression: hotspots and frontiers

Yang

et al. 2023

Preprint

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Background Post-stroke depression(PSD) is one of the most common complications of stroke which affects recovery and quality of patients’ life adversely. PSD also is a significant source of burden for caregivers. Recently, the number of publications on PSD has been an increasing worldwide that means PSD has attracted more and more attention. Therefore, a more comprehensive understanding of the publications on PSD is now required. The purpose of this paper is to analyze the research status, discover the hotspots and frontiers about PSD. Methods The publications’ raw data was retrieved from the Web of Science Core Collection on September 19, 2022. Impact Factor (IF) and Journal Citation Reports (JCR) segments of the publications were obtained from the Web of Science website. Visualization analysis was performed on CiteSpace and VOSviewer. Results From 2012 to 2022, the number of citations and publications about PSD increased exponentially year by year. Finally, a total of 3268 publications related to PSD were identified. China (867) and the US (738) had the most publications; Capital Med Univ and Univ Melbourne were the most prolific institutions. Ungvari GS and Hackett ML were the most active authors and the most prolific and co-cited, respectively. Journal of stroke cerebrovascular diseases (131 articles) was the highest output. Among the 3268 publications, International journal of stroke had the most citations (43.9 times), Stroke has the most citations (2,990) and the highest H-index value. The citation burst for 8 co-cited references lasts until 2022. Finally, this paper divided the hot spots into four categories: cluster 1 (study on risk factors of PSD), cluster 2 (clinically relevant research on PSD), cluster 3 (mechanisms of PSD), and cluster 4 (the Treatment Study for PSD). Conclusion PSD research is one research main area worldwide. This work demonstrated the knowledge structure and the evolution of the PSD research field and predictdresearches trends through visual analysis. The study of clinical treatment and prevention of PSD will instead of the study of the mechanism in the future. This study provides reference for future research of PSD.

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“…Many studies showed that some dietary natural products and nutrients had protective effects against depression through different mechanisms, including an anti-inflammatory effect, antioxidant effect, promoting the production of monoamine neurotransmitters, normalizing the hyperactivity of the HPA axis, regulating the microbiota–gut–brain axis, and other mechanisms [ 7 , 38 , 39 ], which are discussed in detail below ( Table 2 and Figure 1 ).…”

Section: Depressionmentioning

confidence: 99%

“…The HPA axis is an important part of the neuroendocrine system and plays an essential role in the control of stress response and the mediation of mood [ 64 ]. The hyperactivity of the HPA axis inhibited the negative feedback signal of cortisol and upregulated the levels of corticotropin-releasing factor (CRF) and adrenocorticotropic hormone (ACTH), which further resulted in depressive symptoms [ 38 ]. It was found that eicosapentaenoic acid (EPA)-enriched phospholipids suppressed HPA axis hyperactivity to ameliorate depressive symptoms induced by chronic stress and lipopolysaccharide (LPS) [ 65 ].…”

Section: Depressionmentioning

confidence: 99%

Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

Zhou

et al. 2022

Antioxidants

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Depression and anxiety are severe public health problems and have attracted more and more attention from researchers of food science and nutrition. Dietary natural products and nutrients, such as fish, coffee, tea, n-3 PUFA, lycopene, and dietary fiber, could play a vital role in the prevention and management of these diseases. The potential mechanisms of action mainly include inhibiting inflammation, ameliorating oxidative stress, modulating the microbiota–gut–brain axis, suppressing hypothalamic–pituitary–adrenal axis hyperactivity, and regulating the levels of monoamine neurotransmitters. In this narrative review, we summarize the most recent advancements regarding the effects of dietary natural products and nutrients on depression and anxiety, and their underlying mechanisms are discussed. We hope that this paper can provide a better understanding of the anti-depressive and anxiolytic action of dietary natural products, and that it is also helpful for developing dietary natural products for functional food, dietary supplements, or auxiliary agents for the prevention and management of these diseases.

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The etiology of poststroke-depression: a hypothesis involving HPA axis

Cited by 26 publications

References 108 publications

Treatments to post-stroke depression, which is more effective to HAMD improvement? A network meta-analysis

Treatments to post-stroke depression, which is more effective to HAMD improvement? A network meta-analysis

Bibliometric analysis of global research trends in post-stroke depression: hotspots and frontiers

Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review

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