The Etiology of Neonatal Intensive Care Unit Death in Extremely Low Birth Weight Infants: A Multicenter Survey in China

Zhou, Jianguo; Ba, Yin; Du, Yang; Lin, Sam Bill; Chen, Chao

doi:10.1055/s-0040-1701611

Cited by 9 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BPD is an important medical condition that causes morbidity and mortality among very-low-birth-weight infants (4). It is affected by multiple factors, including antenatal, postnatal and genetic factors, such as maternal smoking, intrauterine growth restriction, intrauterine inflammation, mechanical ventilation, oxygen supplementation after birth, and cardiovascular malformation (22).…”

Section: Discussionmentioning

confidence: 99%

“…In some of these infants, worse cognitive and psychomotor development are also observed later in their development (6). We also considered death to be our outcome measure because death was a competing outcome with BPD (23) and BPD was a major cause of death (4). In this study, we developed and validated an easy-to-use nomogram as a new approach to diagnose BPD.…”

Section: Discussionmentioning

confidence: 99%

“…With the evolution of perinatal medical and respiratory support technology, the mortality of extremely preterm infants has been dramatically reduced, but the incidence of BPD has not changed over the last decades due to the increased survival of preterm newborns (3). BPD is still the major cause of mortality among preterm babies in Level III neonatal units in China (4). Some longitudinal studies have shown that BPD patients develop respiratory infections more frequently in the first 2 years of life and that their airway function is reduced during childhood (5).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development and Validation of a Nomogram for Predicting Bronchopulmonary Dysplasia in Very-Low-Birth-Weight Infants

et al. 2021

View full text Add to dashboard Cite

Background: Bronchopulmonary dysplasia is a common pulmonary disease in newborns and is one of the main causes of death. The aim of this study was to build a new simple-to-use nomogram to screen high-risk populations.Methods: In this single-center retrospective study performed from January 2017 to December 2020, we reviewed data on very-low-birth-weight infants whose gestational ages were below 32 weeks. LASSO regression was used to select variables for the risk model. Then, we used multivariable logistic regression to build the prediction model incorporating these selected features. Discrimination was assessed by the C-index, and and calibration of the model was assessed by and calibration curve and the Hosmer-Lemeshow test.Results: The LASSO regression identified gestational age, duration of ventilation and serum NT-proBNP in the 1st week as significant predictors of BPD. The nomogram-illustrated model showed good discrimination and calibration. The C-index was 0.853 (95% CI: 0.851–0.854) in the training set and 0.855 (95% CI: 0.77–0.94) in the validation set. The calibration curve and Hosmer-Lemeshow test results showed good calibration between the predictions of the nomogram and the actual observations.Conclusion: We demonstrated a simple-to-use nomogram for predicting BPD in the early stage. It may help clinicians recognize high-risk populations.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development and Validation of a Nomogram for Predicting Bronchopulmonary Dysplasia in Very-Low-Birth-Weight Infants

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Bronchopulmonary dysplasia (BPD) is a severe pulmonary complication of prematurity, and the leading cause of post-neonatal death in extremely preterm infants in neonatal intensive care units (NICUs) [ 1 , 2 ]. The current National Institute of Child Health and Human Development (NICHD) consensus definition of BPD is based on oxygen requirement and clinically assessed need for supplementary respiratory support at 28 days postnatal age and 36 weeks postmenstrual age (PMA) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

A modified lung ultrasound score to evaluate short-term clinical outcomes of bronchopulmonary dysplasia

Sun

Shen

et al. 2022

BMC Pulm Med

Self Cite

View full text Add to dashboard Cite

Background Lung ultrasound (LUS) is a useful tool for assessing the severity of lung disease, without radiation exposure. However, there is little data on the practicality of LUS in assessing the severity of bronchopulmonary dysplasia (BPD) and evaluating short-term clinical outcomes. We adapted a LUS score to evaluate BPD severity and assess the reliability of mLUS score correlated with short-term clinical outcomes. Methods Prospective diagnostic accuracy study was designed to enroll preterm infants with gestational age < 34 weeks. Lung ultrasonography was performed at 36 weeks postmenstrual age. The diagnostic and predictive values of new modified lung ultrasound (mLUS) scores based on eight standard sections were compared with classic lung ultrasound (cLUS) scores. Results A total of 128 infants were enrolled in this cohort, including 30 without BPD; 31 with mild BPD; 23 with moderate BPD and 44 with severe BPD. The mLUS score was significantly correlated with the short-term clinical outcomes, superior to cLUS score. The mLUS score well correlated with moderate and severe BPD (AUC = 0.813, 95% CI 0.739–0.888) and severe BPD (AUC = 0.801, 95% CI 0.728–0.875), which were superior to cLUS score. The ROC analysis of mLUS score to evaluate the other short-term outcomes also showed significant superiority to cLUS score. The optimal cutoff points for mLUS score were 14 for moderate and severe BPD and 16 for severe BPD. Conclusions The mLUS score correlates significantly with short-term clinical outcomes and well evaluates these outcomes in preterm infants.

show abstract

“…Bronchopulmonary dysplasia (BPD) is a chronic neonatal lung disease with adverse effects on pre-mature infants. It is related to adverse long-term pulmonary and neurodevelopmental outcomes, especially in very low birth weight infants (VLBW) (1)(2)(3)(4). Over the past 50 years, unlike other complications affecting VLBW, there has been no substantial decrease in the incidence of BPD despite of improvements in neonatal care (5).…”

Section: Introductionmentioning

confidence: 99%

Long-Term Outcomes of Bronchopulmonary Dysplasia Under Two Different Diagnostic Criteria: A Retrospective Cohort Study at a Chinese Tertiary Center

Zhang

Bao

et al. 2021

Front. Pediatr.

View full text Add to dashboard Cite

Unlike other complications among very low birth weight infants (VLBW), the incidence of bronchopulmonary dysplasia (BPD) has not decreased substantially, partly because of the different definitions of BPD applied by different researchers. In this retrospective cohort study, we aimed to compare the 2018 revised definition and the 2001 consensus definition of BPD proposed by the National Institute of Child Health and Human Development (NICHD), as well as to identify which definition better predicts severe respiratory morbidities or death. We included 417 infants born at a gestational age <32 weeks and classified them as having BPD or without BPD based on the two definitions, with a final follow-up at 18–24 months. We performed between-group comparisons of death and respiratory outcomes. Statistical analyses were performed using descriptive statistics, comparative tests, and receiver operating characteristic curves. The mean ± standard deviation gestational age and birth weight of the 417 eligible infants were 29.1 ± 1.4 weeks and 1186.6 ± 197.8 g, respectively. Among the included infants, five and three infants died before and after 36 weeks of post-menstrual age (PMA), respectively, with 68 and 344 infants evaluated at discharge and 36 weeks' PMA, respectively. We diagnosed 163 (39.1%) and 70 (16.8%) infants with BPD according to the 2001 and 2018 NICHD definitions, respectively. The 2001 NICHD definition displayed a higher sensitivity (0.60 vs. 0.28), better negative predictive value (0.89 vs. 0.85), and larger area under the receiver operating characteristic curve (0.66 vs. 0.57), but a lower specificity (0.65 vs. 0.87) and worse positive predictive value (0.26 vs. 0.31), than the 2018 definition for serious respiratory morbidity or mortality at a corrected age of 18–24 months. Compared with the 2018 NICHD definition of BPD, the 2001 NICHD consensus definition may result in more cases of false-positive or unclassified severity. However, it may be a better indicator of severe respiratory morbidities or death during the first 18–24 months. Nevertheless, there is a need for future studies to assess the validity of the new diagnostic criteria.

show abstract

The Etiology of Neonatal Intensive Care Unit Death in Extremely Low Birth Weight Infants: A Multicenter Survey in China

Cited by 9 publications

References 29 publications

Development and Validation of a Nomogram for Predicting Bronchopulmonary Dysplasia in Very-Low-Birth-Weight Infants

Development and Validation of a Nomogram for Predicting Bronchopulmonary Dysplasia in Very-Low-Birth-Weight Infants

A modified lung ultrasound score to evaluate short-term clinical outcomes of bronchopulmonary dysplasia

Long-Term Outcomes of Bronchopulmonary Dysplasia Under Two Different Diagnostic Criteria: A Retrospective Cohort Study at a Chinese Tertiary Center

Contact Info

Product

Resources

About