The etiology of autoimmune diabetes and thyroiditis: evidence for common genetic susceptibility

Levin, Lara; Tomer, Yaron

doi:10.1016/s1568-9972(03)00080-6

Cited by 67 publications

(51 citation statements)

References 25 publications

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“…Abundant epidemiological data supports a genetic basis of T1D and AITD. Each disease is thought to be influenced by multiple susceptibility genes, as well as, environmental factors (10). The high prevalence of anti-thyroid peroxidase antibodies (anti-TPO) in patients with T1D prompts the necessity for further thyroid function evaluation (11).…”

Section: Introductionmentioning

confidence: 99%

Organ Specific Autoantibodies in Preclinical and Early Clinical Type 1 Diabetes in Turkey

Erten¹,

Gürol²,

Deniz³

et al. 2007

Upsala Journal of Medical Sciences

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Type 1 diabetes mellitus (T1D) patients (G1; n=73) and first degree relatives with of FPIR (G2; n=18) were screened for two other autoantibodies, anti-glutamic acid decarboxylase (GADA) and insulin autoantibodies (IAA), and for other organ-specific autoantibodies, anti-gastric parietal cell (anti-PCA) and anti-thyroid peroxidase (anti-TPO) as well. The two control groups consisted of healthy subjects (G3; n:55 and G4; n:13). In G1, positivity of ICA, GADA, IAA, anti-TPO and anti-PCA were 63%, 75.1%, 27.4%, 17.8% and 8.2%, respectively. In G2, positivity for GADA, IAA, anti-TPO and anti-PCA were 55.6%, 11.1%, 16.7% and 11.1%, respectively. None of the anti-TPO or anti-PCA positive cases had clinical or laboratory thyroid disease or pernicious anemia.Other organ specific antibodies, in case they accompany GADA and/or IAA in high risk individuals, result in higher risk for T1D. Moreover, this condition may indicate future potential for developing thyrogastric autoimmune diseases.In conclusion; autoantibodies are markers for autoimmune destruction in T1D, and for identification of subjects at risk for disease. Even at the time of diagnosis of T1D, screening for thyrogastric autoimmunity might be recommended for early detection of the relevant diseases.

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Section: Introductionmentioning

confidence: 99%

Organ Specific Autoantibodies in Preclinical and Early Clinical Type 1 Diabetes in Turkey

Erten¹,

Gürol²,

Deniz³

et al. 2007

Upsala Journal of Medical Sciences

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“…The most widely accepted is the autoimmune genetic hypothesis, assuming involvement of genes associated with immune regulation [17]. Numerous observations have confirmed that genetic susceptibility is shared among autoimmune diseases, with the strongest association seen between T1DM and autoimmune thyroid disease (AITD) [11,12,[18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Przypadek pokrzywki autoimmunologicznej współistniejącej z autoimmunologicznym zespołem wielogruczołowym typu III związanym z chorobą Hashimoto, cukrzycą typu 1 i bielactwem

Kasznicki¹,

Drzewoski²

2014

Endokrynologia Polska

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We present a case of autoimmune polyglandular syndrome type III (APS III) associated with Hashimoto's disease, type 1 diabetes mellitus, vitiligo and autoimmune urticaria. This rare genetic disorder occurs with unknown frequency in the Polish population. It is characterised by endocrine tissue destruction resulting in the malfunction of multiple organs. Several cases of APS III associated with organ-specific autoimmune diseases such as coeliac disease, hypogonadism and myasthenia gravis, as well as organ-nonspecific or systemic autoimmune diseases such as sarcoidosis, Sjögren syndrome, and rheumatoid arthritis have been described. To the best of our knowledge, we here describe the first case of APS III associated with autoimmune thyroiditis, type 1 diabetes mellitus, vitiligo and autoimmune urticaria in an adult patient.

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“…Из всех ва-риантов сочетаний АИЗ наиболее четко это прослежива-ется для СД1 и аутоиммунных заболеваний щитовидной железы (АИЗ ЩЖ) [6][7][8][9][10]. Распространенность АИЗ ЩЖ у родственников больных СД1 достигает 48% по срав-нению с общей популяцией -лишь 3-10% [6,[11][12][13].…”

Section: /2013unclassified

Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis

et al. 2013

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Сравнительный анализ распределения частот аллелей и генотипов HLA II класса у пациентов с сахарным диабетом 1 типа в отсутствие и в сочетании с аутоиммунным тиреоидитом Репина Е.А., Атаманова Т.М., Зверева Я.С., Тишина Ю.В., Прокофьев С.А. ФГБУ Эндокринологический научный центр

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The etiology of autoimmune diabetes and thyroiditis: evidence for common genetic susceptibility

Cited by 67 publications

References 25 publications

Organ Specific Autoantibodies in Preclinical and Early Clinical Type 1 Diabetes in Turkey

Organ Specific Autoantibodies in Preclinical and Early Clinical Type 1 Diabetes in Turkey

Przypadek pokrzywki autoimmunologicznej współistniejącej z autoimmunologicznym zespołem wielogruczołowym typu III związanym z chorobą Hashimoto, cukrzycą typu 1 i bielactwem

Comparative analysis of HLA II allele and genotype frequency distribution in patients with type 1 diabetes mellitus and autoimmune thyroiditis

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