The etiology of acquired hemolytic anemia

Zuelzer, Wolf W.; Stulberg, Cyril S.; Page, R. H.; Teruva, José; Brough, A. Joseph

doi:10.1016/s0022-3476(65)81853-4

Cited by 11 publications

(8 citation statements)

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“…However, a causal association should be made with caution since intercurrent infections occur frequently in young children. In the pres ent studies, cytomegalovirus infection did not seem to be as important a factor in the aetiology of AIH as previously suggested [5,[11][12][13]. This may have been due to dif ferences in population, since in many of these previous cases, a varying degree of immune deficiency (which predisposes towards cytomegalovirus infection) was found [5,12], Only AP and BB had AIH secondary to an underlying chronic disorder (table I): in SJ and SA the haemolysis was consid ered to be related to Mycoplasma infec tions rather than to Down's syndrome (SJ), or to acute lymphoblastic leukaemia (SA).…”

Section: Association With Other Disorderssupporting

confidence: 53%

“…In the pres ent studies, cytomegalovirus infection did not seem to be as important a factor in the aetiology of AIH as previously suggested [5,[11][12][13]. This may have been due to dif ferences in population, since in many of these previous cases, a varying degree of immune deficiency (which predisposes towards cytomegalovirus infection) was found [5,12], Only AP and BB had AIH secondary to an underlying chronic disorder (table I): in SJ and SA the haemolysis was consid ered to be related to Mycoplasma infec tions rather than to Down's syndrome (SJ), or to acute lymphoblastic leukaemia (SA). In other series, AIH secondary to underlying chronic disorders made up a much higher proportion of cases, and im mune deficiency, collagen or lymphoproliferative diseases were seen in up to near ly 40% of patients [4,[6][7][8][9][10].…”

Section: Association With Other Disorderssupporting

confidence: 53%

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Autoimmune Haemolysis in Childhood and Adolescence

et al. 1984

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The clinico-pathological features of 42 children with autoimmune haemolysis are described. Over 65 % of cases were seen before their 5th birthday. In this group males predominated by the ratio of 2.5:1, but in the older children both sexes were equally affected. The incidence decreased from 1 in 188 × 10³ in young males to 1 in 1,780 × 10³ in children over 10. Cases were classified serologically. Of particular note was the frequency of Donath-Landsteiner haemolysis which equalled that due to warm autoantibodies; together these groups made up 79% of the total cases. Most haemolytic episodes followed an acute infection. This was frequently mild and often involved the upper respiratory tract; in only 2 patients was haemolysis associated with underlying collagenosis. Typically there was a sudden onset of pallor and malaise; jaundice, splenomegaly and hepatomegaly were found in about half the subjects. Haemoglobinuria was characteristic of Donath-Landsteiner haemolysis. The illness was severe, with Hb levels falling below 6.0 g/dl in 28 patients. Prednisolone, blood transfusion and, where indicated, antibiotics were usually effective in treating the illness, with splenectomy reserved for cases where this treatment was unsatisfactory. In several individuals no treatment was required. Recovery was rapid, and complete recovery occurred in 83 % of patients, usually within 6 months. Although 2 patients died, a generally optimistic prognosis can be given, particularly in the absence of an underlying chronic disorder.

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Section: Association With Other Disorderssupporting

confidence: 53%

Section: Association With Other Disorderssupporting

confidence: 53%

Autoimmune Haemolysis in Childhood and Adolescence

et al. 1984

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“…Acute infections or immunizations preceded AIHA in over 50% of 44 children reported by Ż upańska et al [23]. AIHA has been associated with CMV infection and CMV may initiate AIHA in children [22] as perhaps it did in this infant.…”

Section: Discussionmentioning

confidence: 87%

Intensive plasma exchange for severe autoimmune hemolytic anemia in a four-month-old infant

et al. 1999

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“…In certain instances enlarged lymph nodes exhibited histologic and cytologic changes, indicating that they were the primary site of cytomegalovirus multiplication prior to general dissemination [18). The recovery of virus from adenoid tissue |8|.…”

Section: Commentmentioning

confidence: 99%