The etiologies of post-stroke depression: Different between lacunar stroke and non-lacunar stroke

Wang, Ke-Wu; Xu, Yang-Miao; Lou, Chaobin; Jing, Huang; Feng, Chao

doi:10.1016/j.clinsp.2022.100095

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…Studies about the significance of lesion location in PSD showed quite controversial results. However, the most frequently-mentioned locations that might be associated with PSD were frontal and temporal lobes, amygdala and the fronto-limbic-striatal circuit 10 , 35 , 36 , which were also the locations involved in the adjustment of autonomic nervous system and post-stroke arrhythmia. Based on the similar pathogenesis with similar locations involved in their occurrence, it’s reasonable that the occurrence of post-stroke arrhythmia could predict the occurrence of PSD.…”

Section: Discussionmentioning

confidence: 99%

Post-stroke arrhythmia could be a potential predictor for post-stroke depression

Xu,

Dong,

Zhang

et al. 2024

Sci Rep

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Post-stroke depression (PSD) is regarded as the consequence of multiple contributors involving the process of cognition, mood and autonomic system, with the specific mechanism unclear yet. As a common type of stroke-heart syndromes, post-stroke arrhythmia shared some common pathogenesis with PSD. We presumed that post-stroke arrhythmia might be an early distinguishable marker for the presence of PSD and aimed to verity their association in this study. Patients with first-ever ischemic stroke were enrolled. The presence of post-stroke ectopic arrhythmia and the symptoms of arrhythmia were recorded with anti-arrhythmia drugs prescribed when necessary. Patients were followed up 3 months later to identify their presence and severity of PSD using Hamilton Depression Scale (HAMD) and also presence and severity of arrhythmia. Characteristics including the prevalence of various types of arrhythmias were compared between PSD and non-PSD groups. The HAMD scores were compared between patients with and without arrhythmia in PSD group. Logistic regression was used to identify the independent predictor of PSD. Patients with PSD had higher prevalence of post-stroke arrhythmia especially newly-detected arrhythmia, symptomatic arrhythmia and poor-controlled arrhythmia. In PSD group, patients of post-stroke arrhythmia had higher scores of HAMD than those without arrhythmia. Presence of newly-detected, symptomatic and poor-controlled arrhythmias were independent predictor of PSD. post-stroke arrhythmia especially newly-detected arrhythmia and symptomatic arrhythmia could be an early predictor of PSD. Successful control of arrhythmia was associated with reduced prevalence and severity of PSD.

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Section: Discussionmentioning

confidence: 99%

Post-stroke arrhythmia could be a potential predictor for post-stroke depression

Xu,

Dong,

Zhang

et al. 2024

Sci Rep

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“…Thirdly, the differential metabolites in plasma were not further verified by targeted metabolomic or other biochemical methods. Fourthly, since TOAST type 52 and treatment methods 53 may affect the pathogenesis of PSD, the effects of these factors on plasma metabolomics in PSD patients should also be explored in large samples in the future. The strengths of this study are that we explored the metabolic alterations and identified a panel of biomarkers for PSD only in ischemic stroke patients.…”

Section: Limitations and Strengthsmentioning

confidence: 99%

Metabolic Alterations and Related Biological Functions of Post-Stroke Depression in Ischemic Stroke Patients

Wen¹,

Yan²,

Zheng³

et al. 2023

NDT

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Background Post-stroke depression (PSD) is one of the most common neuropsychiatric complications after stroke. However, the underlying mechanisms of PSD remain ambiguous, and no objective diagnosis tool is available to diagnose PSD. Previous metabolomic studies on PSD included patients with ischemic and hemorrhagic stroke indiscriminately, which is not conducive to elucidating and predicting the occurrence of PSD. The aim of this study is to elucidate the pathogenesis of PSD and provide potential diagnostic markers for PSD in ischemic stroke patients. Methods In total, 51 ischemic stroke patients at 2 weeks were included in this study. Those with depressive symptoms were assigned to the PSD group, while the others were assigned to the non-PSD group. Plasma metabolomics based on liquid chromatography–mass spectrometry (LC-MS) was performed to explore the differential plasma metabolites between the PSD and non-PSD groups. Results Principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) showed significant metabolic alterations between PSD patients and non-PSD patients. In total, 41 differential metabolites were screened out, mainly including phosphatidylcholines (PCs), L-carnitine and acyl carnitines, succinic acid, pyruvic acid and L-lactic acid. Metabolite-related pathway analysis revealed that alanine, aspartate and glutamate metabolism, glycerophospholipid metabolism and the citrate cycle (TCA cycle) may contribute to the pathogenesis of PSD. A panel of three signature metabolites [PC(22:5(7Z,10Z,13Z,16Z,19Z)/15:0), LysoPA(18:1(9Z)/0:0) and 1,5-anhydrosorbitol] was determined as potential biomarkers for PSD in ischemic stroke patients. Conclusion These findings are conducive to providing new insights into the pathogenesis of PSD and developing objective diagnostic tools for PSD in ischemic stroke patients.

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Depression in patients with cerebral microangiopathy

Боголепова

2023

RJTAO

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Cerebral microangiopathy (CMA) is one of the significant causes of depression in the elderly. Close associations of the risk of developing depression with white matter hyperintensity, the presence of lacunar infarcts, and other markers of vascular disease are shown. The available data suggest that various vascular mechanisms, in particular, involvement of small vessels of the brain, generalized microvascular and endothelial dysfunction, metabolic risk factors, – are risk factors for the development of depression. Pathogenetic mechanisms include cerebral hypoperfusion and immune dysregulation. Depression is also a common complication of coronavirus infection, occurring both in the acute and postCOVID periods. The same mechanisms as in vascular depression are involved in the pathogenesis of the development of post-COVID depressive disorders. Given the complexity of the mechanisms of development of depressive disorders in patients with CMA, the presence of severe comorbid vascular pathology, antidepressants with an optimal ratio of efficacy and safety should be preferred. Agomelatine (Valdoxan) is one of such drugs.

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The etiologies of post-stroke depression: Different between lacunar stroke and non-lacunar stroke

Cited by 3 publications

References 45 publications

Post-stroke arrhythmia could be a potential predictor for post-stroke depression

Post-stroke arrhythmia could be a potential predictor for post-stroke depression

Metabolic Alterations and Related Biological Functions of Post-Stroke Depression in Ischemic Stroke Patients

Depression in patients with cerebral microangiopathy

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