The Etiological Relationship Between Migraine and Sudden Hearing Loss

Arslan, Yıldız; Arslan, İlker Burak; Aydin, Huriye; Yagiz, O; Tokuçoğlu, Figen; Çukurova, İbrahim

doi:10.1097/mao.0000000000001617

Cited by 12 publications

(19 citation statements)

References 13 publications

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“…There are a number of studies that described fluctuating or permanent SSNHL in patients with migraine. In other words, migraine has been found to be a risk factor of sudden deafness [Viirre et al, 1996;Evans et al, 2009;Arslan et al, 2017;Hwang et al, 2018;Kim et al, 2019]. A population-based cohort study conducted in the Re-public of Korea, which included 44,714 individuals, showed that the risk of development of SSNHL in patients with migraine was 1.34 times higher than in controls [Bolay et al, 2008].…”

Section: Discussionmentioning

confidence: 99%

“…(1) The most accepted theory is based on the vascular mechanism of migraine. Vasospasms associated with migraine in small arterioles within the cochlea and labyrinth can induce the ELH [Radtke et al, 2012;Blödow et al, 2014;Arslan et al, 2017;Kırkım et al, 2017]. (2) Some inflammations and neurotransmitters involved in the pathogenesis of migraine affect the inner ear and the central auditory system [Balaban, 2011].…”

Section: Discussionmentioning

confidence: 99%

“…This pathophysiology can induce endolymphatic hydrops (ELH). That can explain the audiological changes in patients with migraine and VM [Balaban, 2011;Radtke et al, 2012;Blödow et al, 2014;Gürkow et al, 2014;Arslan et al, 2017;Kırkım et al, 2017]. VM not only has vertigo symptoms similar to MD, but also the pathological manifestations are similar.…”

Section: Introductionmentioning

confidence: 98%

“…In terms of phonophobia, some research about auditory of migraine has been reported. Nowadays, there are many studies reporting sudden sensorineural hearing loss (SSNHL) in patients with migraine [Viirre et al, 1996;Evans et al, 2009;Arslan et al, 2017;Hwang et al, 2018;Kim et al, 2019]. But the auditory in VM patients have not been widely investigated.…”

Section: Introductionmentioning

confidence: 99%

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Audiological Findings in Patients with Vestibular Migraine and Migraine: History of Migraine May Be a Cause of Low-Tone Sudden Sensorineural Hearing Loss

Xue

Lin

et al. 2020

Audiol Neurotol

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Introduction: The aim of this study was to investigate and compare the auditory findings in migraine, vestibular migraine (VM), and healthy controls. Methods: Twenty-eight migraine patients (56 ears), 18 VM (36 ears), and 25 healthy controls (50 ears) were included. Audiometry, speech discrimination scores, distortion product optoacoustic emission (DPOAE), and auditory brainstem response were tested. Results: The pure tone in the VM group showed higher thresholds at lower frequencies (250, 500, 1,000, 2,000 Hz) than the control group, with statistical differences observed (P_{250 Hz} = 0.001, P_{500 Hz} = 0.003, P_{1,000 Hz} = 0.016, P_{2,000 Hz} = 0.002). Compared with the healthy controls, the patients with VM had significantly lower amplitudes of DPOAE at 1 kHz (p < 0.001) and 2 kHz (p = 0.020), and the patients with migraine had lower amplitudes at 2 kHz (p = 0.042). Compared with the control group, the patients with migraine reported prolonged latency of wave V (p = 0.016) and IPL I–V (p = 0.003). The patients with VM had significant prolongation of IPL I–V (p = 0.024). Conclusion: Not only the peripheral, but also the central auditory system was involved in patients with migraine and VM. In particular, lower frequencies of the auditory system were more likely to be involved in VM. The history of migraine may be a cause of low-tone sudden sensorineural hearing loss.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Audiological Findings in Patients with Vestibular Migraine and Migraine: History of Migraine May Be a Cause of Low-Tone Sudden Sensorineural Hearing Loss

Xue

Lin

et al. 2020

Audiol Neurotol

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“…3,14,15 There have also been nationwide population-based and prospective cohort studies suggesting that migraine, a complex neurovascular disorder, can increase the risk for developing SSNHL. [16][17][18] Thus, we present an investigation to evaluate the efficacy of supplementing IT steroid injection with migraine medications in improving SSNHL treatment outcome.…”

Section: Introductionmentioning

confidence: 99%

Adjuvant Migraine Medications in the Treatment of Sudden Sensorineural Hearing Loss

et al. 2020

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Objectives/Hypothesis: To examine the hearing outcomes of patients with sudden sensorineural hearing loss (SSNHL) treated with oral and intratympanic (IT) steroid only or a combination of steroid and migraine treatment. Our hypothesis was that adjuvant migraine medications may improve outcomes in SSNHL. Methods: A retrospective chart review at a tertiary otology center was conducted to identify patients with SSNHL who received oral steroid and IT dexamethasone injection(s) with or without migraine medications (a combination of nortriptyline and topiramate). Results: A total of 47 patients received oral steroid and IT dexamethasone injection(s) only, and 46 patients received oral steroid and IT dexamethasone injection(s) as well as migraine lifestyle changes plus a combination of nortriptyline and topiramate. There were no significant differences in demographics and baseline audiometric data between the two groups. Both groups demonstrated improvements in pure tone average (PTA) and hearing thresholds at 250 Hz and 8000 Hz posttreatment. However, compared to steroid-only group, the adjuvant migraine medications group had significantly greater improvements in hearing thresholds at the lower frequencies (250 Hz, 500 Hz, 1000 Hz). Patients in the latter cohort also had greater improvement in PTA (P = .01) and received fewer IT injections (P = .04) PTA improvement of ≥ 10 dB was observed in 36 patients (78%) in the adjuvant migraine medications group and 22 patients (46%) in the control group (P < .001). Conclusion: In multimodal treatment of SSNHL, supplementing oral and IT steroid with migraine medications may result in greater improvements in lower frequency hearing thresholds and PTA. Furthermore, adjuvant migraine treatment can lead to decrease in number of IT injections, thus reducing procedure-related risks and complications.

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Migraine and risk of sudden sensorineural hearing loss: A systematic review and meta‐analysis

Mohammadi

Balajelini

Rajabi

2020

Laryngoscope Investig Oto

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Objective: The pathophysiology of idiopathic sudden sensorineural hearing loss (SSNHL) is poorly understood. This study aimed to explore the association of migraine and risk of SSNHL in a meta-analysis of population-based cohort studies. Methods: A systematic literature search of studies published until December 2019 was carried out in Medline, Embase, Scopus, Web of Science, and Google Scholar using appropriate keywords. References of the retrieved articles were also examined for inclusion. Random-effects meta-analysis was performed by calculating pooled hazard ratio (HR) and associated 95% confidence interval (CI) using the DerSimonian and Laird method while considering conceptual heterogeneity. Results: Three eligible cohort studies, with 282 250 participants, were included. In total, 56 450 had migraine, and 225 800 had no migraine. Of those with migraine, 0.88% had SSNHL, and among those without migraine, 0.59% had SSNHL. Pooled HR for the risk of SSNHL was 1.84 (95% CI: 1.11-2.57; P < .001). In cohort studies on females, migraine was not significantly the risk of SSHL than no migraine. However, in male cohort studies, the migraine had a higher risk of SSHL than no

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The Etiological Relationship Between Migraine and Sudden Hearing Loss

Abstract: SSNHL patients had a higher prevalence of migraine. Although those with migraine had higher recovery rates, the differences were not statistically significant.

Cited by 12 publications

References 13 publications

Audiological Findings in Patients with Vestibular Migraine and Migraine: History of Migraine May Be a Cause of Low-Tone Sudden Sensorineural Hearing Loss

Audiological Findings in Patients with Vestibular Migraine and Migraine: History of Migraine May Be a Cause of Low-Tone Sudden Sensorineural Hearing Loss

Adjuvant Migraine Medications in the Treatment of Sudden Sensorineural Hearing Loss

Migraine and risk of sudden sensorineural hearing loss: A systematic review and meta‐analysis

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