The ethnopharmacology and toxicology of Urginea sanguinea in the Pretoria area

Foukaridis, G.N.; Osuch, Elzbieta; Mathibe, Lehlohonolo J.; Tsipa, P.

doi:10.1016/0378-8741(95)90034-9

Cited by 17 publications

(10 citation statements)

References 2 publications

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“…A brine shrimp assay showed a seasonal variation in toxicity, with the plant being more toxic in February (late Summer) than in September (Spring). 251 Sekanama sanguinea has traditionally been used for many different conditions, including asthma and it is oen taken by pregnant women. A study by Marx et al 252 (as Urginea sanguinea) showed signicant damage to chick embryos aer exposure to this plant.…”

Section: The Urgineoideaementioning

confidence: 99%

The chemistry and biological activity of the Hyacinthaceae

2013

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The Hyacinthaceae (sensu APGII), with approximately 900 species in about 70 genera, can be divided into three main subfamilies, the Hyacinthoideae, the Urgineoideae and the Ornithogaloideae, with a small fourth subfamily the Oziroëoideae, restricted to South America. The plants included in this family have long been used in traditional medicine for a wide range of medicinal applications. This, together with some significant toxicity to livestock has led to the chemical composition of many of the species being investigated. The compounds found are, for the most part, subfamily-restricted, with homoisoflavanones and spirocyclic nortriterpenoids characterising the Hyacinthoideae, bufadienolides characterising the Urgineoideae, and cardenolides and steroidal glycosides characterising the Ornithogaloideae. The phytochemical profiles of 38 genera of the Hyacinthaceae will be discussed as well as any biological activity associated with both crude extracts and compounds isolated. The Hyacinthaceae of southern Africa were last reviewed in 2000 (T. S. Pohl, N. R. Crouch and D. A. Mulholland, Curr. Org. Chem., 2000, 4, 1287-1324; ref. 1); the current contribution considers the family at a global level.

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Section: The Urgineoideaementioning

confidence: 99%

The chemistry and biological activity of the Hyacinthaceae

2013

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“…According to Watt and Breyer-Brandwijk [ 6 ] and van Wyk and Gericke [ 8 ], traditional healers use the plant to treat venereal infections, abdominal pain, hypertension and numbness and its water extract to purify blood. The bulb is the most used part of Drimia, as it can be applied in emetics, heart tonics, expectorants, diuretics and ointments [ 9 ]. It can increase sex drive in males and help females who are infertile and ease dysmenorrhea [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…The bulb is the most used part of Drimia, as it can be applied in emetics, heart tonics, expectorants, diuretics and ointments [ 9 ]. It can increase sex drive in males and help females who are infertile and ease dysmenorrhea [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Bulbous Plants Drimia: “A Thin Line between Poisonous and Healing Compounds” with Biological Activities

et al. 2021

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Drimia (synonym Urginea) plants are bulbous plants belonging to the family Asparagaceae (formerly the family Hyacinthaceae) and are distinctive, powerful medicinal plants. Just some species are indigenous to South Africa and have been traditionally utilized for centuries to cure various diseases and/or ailments. They have been recognized among the most famous and used medicinal plants in South Africa. Traditionally, the plants are used for various illnesses such as dropsy, respiratory disease, bone and joint complications, skin disorders, epilepsy and cancer. A number of studies have reported biological properties such as antiviral, antibacterial, antioxidant and anti-inflammatory, immunomodulatory, and anticancer activities. Their bulbs are a popular treatment for colds, measles, pneumonia, coughs, fever and headaches. However, some plant species are regarded as one of the six most common poisonous plants in Southern Africa that are toxic to livestock and humans. Due to the therapeutic effects of the Drimia plant bulb, research has focused on the phytochemicals of Drimia species. The principal constituents isolated from this genus are cardiac glycosides. In addition, phenolic compounds, phytosterols and other phytochemical constituents were identified. This study constitutes a critical review of Drimia species’ bioactive compounds, toxicology, biological properties and phytochemistry, advocating it as an important source for effective therapeutic medicine. For this purpose, various scientific electronic databases such as ScienceDirect, Scopus, Google Scholar, PubMed and Web of Science were researched and reviewed to conduct this study. Despite well-studied biological investigations, there is limited research on the toxic properties and the toxic compounds of certain Drimia species. Searching from 2017 to 2021, Google Scholar search tools retrieved 462 publications; however, only 3 investigated the toxicity and safety aspects of Drimia. The aim was to identify the current scientific research gap on Drimia species, hence highlighting a thin line between poisonous and healing compounds, dotted across numerous publications, in this review paper.

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“…The defense mechanisms of U. maritima are screened by the stored compounds of bafadienolides types and caustic saps in the bulbs (Foukaridis et al, 1995;Krenn et al, 2000). The cells of U. maritima contain raphides of calcium oxalate which produce mild inflammation and irritant contact dermatitis when rubbed on the skin (Cogne et al, 2001;Salinas et al, 2001;Makhlouf, 1978) as a major defense and tolerance against herbivores (Ruiz et al, 2002).…”

Section: Defense Mechanismsmentioning

confidence: 99%

“…Urginea sanguinea Schinz has been traditionally used as a blood purifier, abortifacient (Watt and Breyer-Brandwijik, 1962), a treatment for venereal diseases, abdominal pain and backache (Foukaridis et al, 1995). In addition, U. altissima (L.f.) Bak.…”

Section: Pharmaceutical Advantages Of U Maritimamentioning

confidence: 99%

Morphological and anatomical adaptations of the perennial geophyte Urginea maritima (L.) baker (liliaceae) to the mediterranean climate

Al-Tardeh¹

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The thanks I owe for this PhD are rather as many as the words that it consists of, probably equally important and definitely harder to express. I would, nevertheless, like to express my gratitude to everyone, who was, as meant to be, present or absent. I would like to express my deep gratitude to my supervisor Prof. Stylianos Delivopoulos for many things, most of which are difficult to express in words. I thank him for his continuous assistance, guidance, encouragement and friendship during the time I have spent at AUTH, Greece. Moreover, I would like to express my deep gratitude for his kindness and hospitality, for his quantity of enthusiasm and quality of interest. But most of all I thank him for having been both a teacher and a 'father' to me. I would also like to express my gratitude to Dr. Thomas Sawidis for helping me in the subject and scientifical revision of my work. I thank him for his kind heart which has boosted up my enthusiasm and emotions. I will never forget his assistance, discussions and joke especially about the "noble price". I also thank Dr. Barbara-Evelin Diannelidis for her endless assistance and encouragement. I am deeply grateful to the following botanical staff; Prof. Ioannes Tsekos who gave me the opportunity to elaborate my Ph.D at the Aristotle University of Thessaloniki before his retirement. In addition, I would like to express my very deep gratitude for his assistance and critical suggestions that he has made on my research. I also thank Dr. George Nikolaidis, Maria Moustaka and Michael Moustakas for their help and technical support especially in the use of their microscopes. Thanks are also due to Dr. Stylianos Kokkini, Artemios Bosabalidis and Eleftherios Eleftheriou for their moral support and encouragement. I am deep grateful to Dr Emmanuel-Nicholas Panderis for his friendship, jokes and some scientific assistance. Finally, I would like to thank everybody in the Department of Botany for the joyful atmosphere created in the lab during my research work. I also thank the SEM technician Mr. Stavros Oikonomidis for his help in carrying out the SEM protocol. I would like to express my deep gratitude to Mr. Tasos Makrantonakis and Thanasis Nikodimos for their help, moral support and lovely atmosphere created in Sharaf Al-Tardeh Prolegomena vii the TEM laboratory. I also thank Mrs. Soula Sapountzoglou (mama tou kosmou), Pavlos Gaithatzis and the secretary of the Department Mrs Arete Dimopoulou.I express my sincere thanks to my colleagues who, with their behaviour, gave a unique meaning of the concept "team work" and academic ethics. Those folks are Ioannes Akdamakis, Spyros Gelis, Natasa Tsirika, Giorgos Kofidis, Katerina Aligizaki, and Kalopesa Eleni for their constant encouragement and making a friendly atmosphere in the lab. They made sure not let a day pass without joking, smiling and drinking as well.

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The ethnopharmacology and toxicology of Urginea sanguinea in the Pretoria area

Cited by 17 publications

References 2 publications

The chemistry and biological activity of the Hyacinthaceae

The chemistry and biological activity of the Hyacinthaceae

Bulbous Plants Drimia: “A Thin Line between Poisonous and Healing Compounds” with Biological Activities

Morphological and anatomical adaptations of the perennial geophyte Urginea maritima (L.) baker (liliaceae) to the mediterranean climate

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