The ethanolic extract obtained from<i>Campomanesia pubescens</i>(D.C.) O.BERG fruits exerts anxiolytic and antidepressant effects on chronic mild stress model and on anxiety models in Wistar rats: Behavioral evidences

Boas, Gustavo Roberto Villas; Silveira, Ana Paula Stefanello da; Farinelli, Brunna Charlla Feitosa; Cardoso, Cláudia Andréa Lima; Arce, Emely; Oesterreich, Silvia Aparecida

doi:10.1080/1028415x.2018.1466513

Cited by 18 publications

(9 citation statements)

References 48 publications

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“…Regarding emerging therapeutic treatments, subacute and chronic ketamine treatment was demonstrated to have antidepressant, anxiolytic, and precognitive effects by means of the CMS model with great reliability in 2017 [52]. Several drugs, including ginsenoside Rg2, ethanolic extract of Capsicum pubescens fruits (EEFCP), icariin, and lurasidone, have been shown to exert a similar antidepressive action in the past five years [53,54,55,56].…”

Section: Depression Modeling Approachesmentioning

confidence: 99%

Selecting an Appropriate Animal Model of Depression

Hao

Sun

et al. 2019

IJMS

163

112

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Depression has become one of the most severe psychiatric disorders and endangers the health of living beings all over the world. In order to explore the molecular mechanism that underlies depression, different kinds of animal models of depression are used in laboratory experiments. However, a credible and reasonable animal model that is capable of imitating the pathologic mechanism of depression in mankind has yet to be found, resulting in a barrier to further investigation of depression. Nevertheless, it is possible to explain the pathologic mechanism of depression to a great extent by a rational modeling method and behavioral testing. This review aims to provide a reference for researchers by comparing the advantages and disadvantages of some common animal depression models.

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Section: Depression Modeling Approachesmentioning

confidence: 99%

Selecting an Appropriate Animal Model of Depression

Hao

Sun

et al. 2019

IJMS

163

112

View full text Add to dashboard Cite

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“…It is important to note that chemically synthesized drugs are generally improved derivatives of prototypes of herbal isolated drugs [6]. Moreover, it has been observed that medicinal plants or extracts, used as co-adjuvant or as alternate therapy to allopathic medicine, are effective and have few adverse effects, as well as being low cost and locally available [7]. Flavonoids are ubiquitous plant secondary metabolites found in plants.…”

Section: Introductionmentioning

confidence: 99%

Quercetin Exerted Protective Effects in a Rat Model of Sepsis via Inhibition of Reactive Oxygen Species (ROS) and Downregulation of High Mobility Group Box 1 (HMGB1) Protein Expression

Cui

Peng

et al. 2019

Med Sci Monit

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Background Sepsis is a severe medical condition. Approximately 0.75 million people are diagnosed with sepsis in the USA annually. Several of anti-inflammatory drugs are used to manage sepsis, but with a very low success rate. This study examined the possible protective effects of a naturally occurring flavanone, quercetin, in a rat model of sepsis. Material/Methods The study was carried out using Wistar albino rats. Sepsis was induced by cecal ligation and puncture methods. Histological analysis was performed by hematoxylin and eosin (HE) staining. Reactive oxygen species (ROS) levels were determined by flow cytometery. Superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX) activities were determined by standard assays. Protein expression was determined by Western blot analysis. Results The results showed that quercetin reduced the tissue edema, congestion, and hemorrhage, increased the alveolar volume, and helped to maintain the lung anatomy of septic rats. Admistration of quercetin at the dosage of 15 and 20 mg/kg to septic rats caused significant reduction in the ROS levels. The activities and the expression of SOD, CAT, and APX were significantly decreased upon administration of quercetin in the septic rats at the dosage of 15 and 20 mg/kg. The effects of quercetin were also examined on the expression of the High mobility group box 1 (HMGB1) protein in septic rats. The results showed that quercetin caused a significant decrease in HMGB1 protein levels. Conclusions The findings of this study suggest that quercetin has therapeutic potential in the treatment of sepsis.

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“…Each stress stimulus was discontinuous and irregular. Administration of Andro/fluoxetine/K252a/vehicle was performed daily during the final 2 weeks (Zu et al, 2017; Sanna et al, 2018; Villas Boas et al, 2018; Wang et al, 2018). To assess the depressive-like behaviors of mice, the FST, TST, and SPT were performed.…”

Section: Methodsmentioning

confidence: 99%

Andrographolide Exerts Significant Antidepressant-Like Effects Involving the Hippocampal BDNF System in Mice

Zhang

Gao

Wang

et al. 2019

International Journal of Neuropsychopharmacology

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Background Major depressive disorder is a worldwide neuropsychiatric disorder associated with various symptoms, but current antidepressants used in clinical practice have various side effects and high failure rates. Andrographolide is the main bioactive ingredient of Andrographis paniculata and exhibits numerous pharmacological actions. This study aimed to evaluate the antidepressant-like effects of andrographolide in male C57BL/6J mice. Methods The antidepressant-like effects of andrographolide in mice were explored in a forced swim test, tail suspension test, and chronic unpredictable mild stress model of depression. Western blotting and immunofluorescence were further performed to assess the effects of chronic unpredictable mild stress and andrographolide on the brain-derived neurotrophic factor signalling cascade and hippocampal neurogenesis. Moreover, a pharmacological inhibitor (K252a) and a lentiviral-short hairpin RNA (LV-TrkB-shRNA) were used to clarify the antidepressant-like mechanism of andrographolide. Results Andrographolide exhibited antidepressant-like potential in the forced swim test and tail suspension test without influencing the locomotor activity of mice. Repeated andrographolide treatment not only produced significant antidepressant-like effects in the chronic unpredictable mild stress model but also prevented the decreasing effects of chronic unpredictable mild stress on hippocampal brain-derived neurotrophic factor signalling and neurogenesis in mice. Importantly, blockade of the hippocampal brain-derived neurotrophic factor system by K252a and TrkB-shRNA fully abolished the antidepressant-like effects of andrographolide in mice. Conclusions Andrographolide exerts antidepressant-like effects in mice via promoting the hippocampal brain-derived neurotrophic factor signalling cascade.

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The ethanolic extract obtained fromCampomanesia pubescens(D.C.) O.BERG fruits exerts anxiolytic and antidepressant effects on chronic mild stress model and on anxiety models in Wistar rats: Behavioral evidences

Abstract: The chemical analysis of the EEFCP indicated high content of flavonoids and the behavioral analysis revealed an antidepressant and anxiolytic effect, suggesting that these phytochemicals may be involved with these actions in the CNS.

Cited by 18 publications

References 48 publications

Selecting an Appropriate Animal Model of Depression

Selecting an Appropriate Animal Model of Depression

Quercetin Exerted Protective Effects in a Rat Model of Sepsis via Inhibition of Reactive Oxygen Species (ROS) and Downregulation of High Mobility Group Box 1 (HMGB1) Protein Expression

Andrographolide Exerts Significant Antidepressant-Like Effects Involving the Hippocampal BDNF System in Mice

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