The etching of glass patterned by microcontact printing with application to microfluidics and electrophoresis

Hannes, Benjamin; Vieillard, Julien; Chakra, Elie Bou; Mazurczyk, Radoslaw; Mansfield, Colin D.; Potempa, Jan; Krawczyk, Stanisław; Cabrera, Michel

doi:10.1016/j.snb.2007.08.025

Cited by 19 publications

(16 citation statements)

References 46 publications

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“…The relief pattern of the stamp is a negative duplication of a silicon master that is micromachined according to the protocol reported by Hannes et al 29,32 The design of the stamp holder, which incorporates a guiding fixture to facilitate the handling of the stamp, is shown in Fig. In this article, we use Rhodorsil 3255 from Rhodia, which is of intermediate 4.4 MPa Young modulus.…”

Section: Description Of the Instrumentmentioning

confidence: 99%

“…29 For other filling factors, it is necessary to significantly reduce the load, as explained in Sec. Consequently, the load during contact was directly dependent on the air pressure, i.e., 7.8 N / bar with a 10 mm diameter piston ͑all pressures in this paper pertain to gauge pressure͒.…”

Section: Guiding and Actuation Of The Stamp Movementmentioning

confidence: 99%

“…29 Therefore, in this work, the machine's architecture will be reviewed and the instrument will be characterized. The use of the first generation of this machine has been reported in a recent article concerning the etching of microfluidic glass devices localized by CP but without detailed explanation about the instrument.…”

Section: Introductionmentioning

confidence: 99%

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A new instrument for automated microcontact printing with stamp load adjustment

Chakra

Hannes

Dilosquer

et al. 2008

Review of Scientific Instruments

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An instrument for automated microcontact printing (microCP) on microscope slides is described. The movement of the stamp, which is actuated by a computer controlled pneumatic actuator, is precisely guided until it makes contact with the substrate. As a consequence, the absolute position of the microprinted patterns is reproducible over a series of substrates with 1 mum standard deviation. Exchange of substrates and stamps is a quick and simple procedure. This makes possible the microprinting of adjacent or superimposable patterns, with different products, in a reproducible manner. Furthermore, a novel approach is described for adjusting the load on the stamp during contact. Two adjustable screws are set up so that their length (with reference to the substrate holder) limits the stamp compression during contact. The load on the stamp is proportional to the stamp compression and from the experimental point of view, this is controlled by the operator adjusting the screws. This makes possible the microCP with stamps incorporating large surface features as well as stamps with isolated features raised on the surface. For proof of concept, automated microCP of a single parallelepiped polydimethylsiloxane feature, with a surface of 2 cm x 30 microm and a height of 25 mum, is demonstrated inside a microfluidic channel without roof collapse. A second example is provided with a single cross feature, possessing an overall surface of 140 x 140 microm(2) and a height of 14 microm. Potential applications of this versatile, inexpensive and compact instrument are discussed. The machine's potential for high throughput also makes it suitable for mass production applications.

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Section: Description Of the Instrumentmentioning

confidence: 99%

Section: Guiding and Actuation Of The Stamp Movementmentioning

confidence: 99%

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A new instrument for automated microcontact printing with stamp load adjustment

Chakra

Hannes

Dilosquer

et al. 2008

Review of Scientific Instruments

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“…With respect to fabrication processes, microfluidic platforms are typically fabricated by etching channels in glass (Hannes et al 2008;Iliescu 2006), injection molding (Edwards et al 2002), hot embossing (Becker and Heim 2000) and micromilling (Mescher et al 2009) of polymers or soft lithography processes (Fujii 2002). However, with regard to the integration of microfluidics with optical platforms based on optical waveguides, these fabrication processes struggle to satisfy the requirements demanded by optical waveguides.…”

Section: Introductionmentioning

confidence: 99%

Development and characterisation of integrated microfluidics on waveguide-based photonic platforms fabricated from hybrid materials

Copperwhite

O’Sullivan

Boothman

et al. 2011

Microfluid Nanofluid

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“…We have recently reported on the development of an automated microcontact printer [24] and as the first example of application with this instrument, the fabrication of microfluidic structures on glass substrates has been described [25]. The objective of this present work is to show the potential of this machine in the field of nanobiotechnology and more precisely, to demonstrate its ability to print biomolecules inside previously etched microfluidic channel.…”

Section: Introductionmentioning

confidence: 99%

Grafting of antibodies inside integrated microfluidic–microoptic devices by means of automated microcontact printing

Chakra¹,

Hannes²,

Vieillard³

et al. 2009

Sensors and Actuators B: Chemical

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A novel approach to integrating biochip and microfluidic devices is reported in which microcontact printing is a key fabrication technique. The process is performed using an automated microcontact printer that has been developed as an application-specific tool. As proof-of-concept the instrument is used to consecutively and selectively graft patterns of antibodies at the bottom of a glass channel for use in microfluidic immunoassays. Importantly, feature collapse due to over compression of the PDMS stamp is avoided by fine control of the stamp's compression during contact. The precise alignment of biomolecules at the intersection of microfluidic channel and integrated optical waveguides has been achieved, with antigen detection performed via fluorescence excitation. Thus, it has been demonstrated that this technology permits sequential microcontact printing of isolated features consisting of functional biomolecules at any position along a microfluidic channel and also that it is possible to precisely align these features with existing components.

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The etching of glass patterned by microcontact printing with application to microfluidics and electrophoresis

Cited by 19 publications

References 46 publications

A new instrument for automated microcontact printing with stamp load adjustment

A new instrument for automated microcontact printing with stamp load adjustment

Development and characterisation of integrated microfluidics on waveguide-based photonic platforms fabricated from hybrid materials

Grafting of antibodies inside integrated microfluidic–microoptic devices by means of automated microcontact printing

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