The Estimation of Thyroid Cancer Risk based on Type 2 Diabetes Mellitus and ABO Blood Group

Oroei, Mahbobeh

doi:10.5505/tjo.2020.2066

Cited by 2 publications

(3 citation statements)

References 18 publications

(26 reference statements)

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“…Multiple previous studies have shown a of ndings (22)(23)(24)(25). A.H. Mansour et al found that patients with blood type O tend to have a higher risk for thyroid cancer (as well as lymphomas and gastric cancers) than any other type of cancer (22).…”

Section: Discussionmentioning

confidence: 98%

“…Hui-xian Yan et al found that AB blood was more frequently associated with malignant than benign thyroid nodules (23). Others, such as Shahrokh et al and Meiling Huang et al, found that blood type B was more associated with the risk of thyroid cancer (24,25). All these different ndings can raise the conclusion that blood type does not predict the risk of malignancy or the benign nature of the disease.…”

Section: Discussionmentioning

confidence: 99%

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Research Title: ABO Blood Types Can Play a Role in Determining Prognosis of Thyroid Cancer in Adult Patients: A Single-centre Retrospective Study.

Ghunaim,

Alkhalifah,

Almontashri

et al. 2023

Preprint

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Background: Thyroid cancer is the most common endocrine malignancy. Previous research has linked the ABO blood group system to the risk and progression of different types of cancer. However, the association between specific blood groups and thyroid cancer risk and prognosis remains unclear. In this study, we aimed to investigate the relationship between ABO blood groups, thyroid cancer risk, and prognosis. Methods: All adult patients who underwent thyroidectomy in our centre between January 2012 and January 2021 were included. A total of 569 files were reviewed, and a total sample of 453 patients were matched after excluding patients with missing data. All sociodemographic, ABO blood groups, Rh factor, and histopathology records were accessed in the study. Result: Out of 435 patients, the majority had malignant thyroid diseases (69.9%). Papillary thyroid cancer was the most common (82.0%). Positive lymph nodes were found in 25% of patients, with blood type B having the highest rate (26.7%). Blood type AB had significantly higher rates of vascular invasion than all other blood types (40% vs 16.3%; p=0.03). Blood type AB was also associated with follicular subtype (20%), larger tumour size, higher capsular invasion (33.3%), and distant metastasis (6.7%). Meanwhile, blood type O had the lowest rates of both lymph node invasion and capsular invasion. Benign disease was significantly associated with hypothyroidism (p<0.001). Additionally, thyroiditis (31.8%) and Hashimoto’s (18.2%) were more common in blood Group B. Conclusion: Blood type AB had the highest rates of capsular invasion, vascular invasion, and distant metastasis compared to other blood types, indicating its potential aggressiveness. On the other hand, blood type O could be less aggressive than other blood groups.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Research Title: ABO Blood Types Can Play a Role in Determining Prognosis of Thyroid Cancer in Adult Patients: A Single-centre Retrospective Study.

Ghunaim,

Alkhalifah,

Almontashri

et al. 2023

Preprint

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“…There is not much research on the association between blood types and the Rh factor in thyroid cancer. Once believed to be a particular marker of PTC cells, the keratan sulfate epitope was shown to be generated concurrently with Poly-N-acetylglucosamine, which contains blood type antigens 16 .…”

Section: Sasmentioning

confidence: 99%

Investigation the role of Human Leukocyte Antigen-G in Iraqi patients with papillary thyroid carcinoma

Aljanabi,

Abed

2024

Baghdad Sci.J

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Human leukocyte antigen G (HLA-G) is a non-classical major histocompatibility complex (MHC) protein with well-known immunomodulatory characteristics. It is also believed to be an important sign of immune tolerance in cancer cells. Immune Escape. HLA-G is also associated with disease development and prognosis in cancer patients. The goal of this study was to compare soluble HLA-G (sHLA-G) levels before and after radioactive iodine therapy (RAI) by enzyme immunoassay (ELISA). Immunohistochemistry was used to examine HLA-G protein expression in thyroid tissues from patients with papillary thyroid cancer (PTC) to investigate the relationship between HLA-G expression and patients' clinical variables. Prospective research included 138 blood samples from patients and controls, as well as 25 thyroid paraffin-embedded tissues from individuals suffering from papillary thyroid cancer (PTC) and controls. Our findings demonstrated a significant difference in the means of people who had radioactive iodine therapy against those who did not (Mean SE = 4.19 0.31, 2.216 0.08, respectively). HLA-G staining, on the other hand, was identified in tumor cells in papillary thyroid cancer, all sections were positive, strongly stained and completely membranous, indicating the presence of HLA-G protein in the tested material. These findings suggest that HLA-G may be involved in the pathogenesis of papillary thyroid cancer.

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The Estimation of Thyroid Cancer Risk based on Type 2 Diabetes Mellitus and ABO Blood Group

Cited by 2 publications

References 18 publications

Research Title: ABO Blood Types Can Play a Role in Determining Prognosis of Thyroid Cancer in Adult Patients: A Single-centre Retrospective Study.

Research Title: ABO Blood Types Can Play a Role in Determining Prognosis of Thyroid Cancer in Adult Patients: A Single-centre Retrospective Study.

Investigation the role of Human Leukocyte Antigen-G in Iraqi patients with papillary thyroid carcinoma

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