The Estimation of Small Amounts of Corticosterone in Rat Plasma

Zenker, Nicolas; Bernstein, Donald E.

doi:10.1016/s0021-9258(18)70434-1

Cited by 349 publications

(16 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The plasma corticosterone levels increased significantly in Group CS vs. Group C, and decreased significantly in Group L+CS vs. Group CS (F [3,20]=5.39, p<0.05). In Group L there was no significant difference vs. Group C (Table 1, Figure 3).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Losartan may prevent the elevation of plasma glucose, corticosterone and catecholamine levels induced by chronic stress

Üresin

Erbas

Ozek

et al. 2004

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

“…NE and E levels were determined by high performance liquid chromatography (HPLC), as described by Krstulovic et al 19 Plasma corticosterone levels were measured by a Jasco FP 750 spectrofluorometer. 20,21…”

Section: Methodsmentioning

confidence: 99%

Losartan may prevent the elevation of plasma glucose, corticosterone and catecholamine levels induced by chronic stress

Üresin

Erbas

Ozek

et al. 2004

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

show abstract

“…Blood samples were collected at 9:00 pm in order to exclude the effect of circadian rhythms on circulating plasma corticosterone. The plasma corticosterone level was estimated fluorometrically, according to the method of Zenker and Bernstein [18].…”

Section: Methodsmentioning

confidence: 99%

Permanent Relief from Intermittent Cold Stress-Induced Fibromyalgia-Like Abnormal Pain by Repeated Intrathecal Administration of Antidepressants

et al. 2011

View full text Add to dashboard Cite

BackgroundFibromyalgia (FM) is characterized by chronic widespread pain, which is often refractory to conventional painkillers. Numerous clinical studies have demonstrated that antidepressants are effective in treating FM pain. We previously established a mouse model of FM-like pain, induced by intermittent cold stress (ICS).ResultsIn this study, we find that ICS exposure causes a transient increase in plasma corticosterone concentration, but not in anxiety or depression-like behaviors. A single intrathecal injection of an antidepressant, such as milnacipran, amitriptyline, mianserin or paroxetine, had an acute analgesic effect on ICS-induced thermal hyperalgesia at post-stress day 1 in a dose-dependent manner. In addition, repeated daily antidepressant treatments during post-stress days 1-5 gradually reversed the reduction in thermal pain threshold, and this recovery was maintained for at least 7 days after the final treatment. In addition, relief from mechanical allodynia, induced by ICS exposure, was also observed at day 9 after the cessation of antidepressant treatment. In contrast, the intravenous administration of these antidepressants at conventional doses failed to provide relief.ConclusionsThese results suggest that the repetitive intrathecal administration of antidepressants permanently cures ICS-induced FM pain in mice.

show abstract

“…Corticosterone levels were estimated by the fluorescence method previously described by Zenker and Bernstein ( 1958 ). Briefly, aliquots of plasma were incubated with chloroform and centrifuged for 5 min at 900 × g , followed by the addition of 0.1 M NaOH and another round of centrifugation.…”

Section: Methodsmentioning

confidence: 99%

Prospecting for a quinoline containing selenium for comorbidities depression and memory impairment induced by restriction stress in mice

et al. 2022

View full text Add to dashboard Cite

Rationale Depression is often associated with memory impairment, a clinical feature of Alzheimer’s disease (AD), but no effective treatment is available. 7-Chloro-4-(phenylselanyl) quinoline (4-PSQ) has been studied in experimental models of diseases that affect the central nervous system. Objectives The pharmacological activity of 4-PSQ in depressive-like behavior associated with memory impairment induced by acute restraint stress (ARS) in male Swiss mice was evaluated. Methods ARS is an unavoidable stress model that was applied for a period of 240 min. Ten minutes after ARS, animals were intragastrically treated with canola oil (10 ml/kg) or 4-PSQ (10 mg/kg) or positive controls (paroxetine or donepezil) (10 mg/kg). Then, after 30 min, mice were submitted to behavioral tests. Corticosterone levels were evaluated in plasma and oxidative stress parameters; monoamine oxidase (MAO)-A and MAO -B isoform activity; mRNA expression levels of kappa nuclear factor B (NF-κB); interleukin (IL)-1β, IL-18, and IL-33; phosphatidylinositol-se-kinase (PI3K); protein kinase B (AKT2), as well as acetylcholinesterase activity were evaluated in the prefrontal cortex and hippocampus. Results 4-PSQ attenuated the depressive-like behavior, self-care, and memory impairment caused by ARS. Based on the evidence, we believe that effects of 4-PSQ may be associated, at least in part, with the attenuation of HPA axis activation, attenuation of alterations in the monoaminergic system, modulation of oxidative stress, reestablishment of AChE activity, modulation of the PI3K/AKT2 pathway, and reduction of neuroinflammation. Conclusions These results suggested that 4-PSQ exhibited an antidepressant-like effect and attenuated the memory impairment induced by ARS, and it is a promising molecule to treat these comorbidities.

show abstract

The Estimation of Small Amounts of Corticosterone in Rat Plasma

Cited by 349 publications

References 9 publications

Losartan may prevent the elevation of plasma glucose, corticosterone and catecholamine levels induced by chronic stress

Losartan may prevent the elevation of plasma glucose, corticosterone and catecholamine levels induced by chronic stress

Permanent Relief from Intermittent Cold Stress-Induced Fibromyalgia-Like Abnormal Pain by Repeated Intrathecal Administration of Antidepressants

Prospecting for a quinoline containing selenium for comorbidities depression and memory impairment induced by restriction stress in mice

Contact Info

Product

Resources

About