The Esterolytic Properties of Synthetic Macromolecules With Pendant Imidazole Groups, Cooperative Effects on the Polymer Chain*

Fullerene-Based Mimics of Biocatalysts Show Remarkable Activity and Modularity

“…In this way, great efforts have been devoted to understanding the well-optimized mechanism-of-action of biocatalysts, and diverse biochemical approaches have been employed to design unnatural analogues. So far, short peptide sequences, − functionalized nanoparticles, , organic catalysts, − polymeric materials, − catalytic antibodies, − and cofactors or metal-introduced bio-macromolecules have been used in the redesign of enzymes through chemical intuition and computational algorithms. − ,− These strategies seek to mimic the versatile aspects of biocatalysts in a minimalistic frame without a well-defined tertiary structure. Short peptides are commonly used in enzyme-inspired biocatalyst studies, and self-assembling peptide sequences are especially preferred due to their ability to recapitulate the protein folding process (Figure ).…”

“…Self-assembly allows optimal and stable interactions between primary units, which facilitate catalytic action in a manner analogous to that of natural catalysts. The activity of such structures stems from the intermolecular interactions between multiple units. , Organic catalyst models generally rely on a fixed active site that is integrated into a given support or cavity, which in turn often limits the capability of these rather rigid structures to remodel enzymatic activity. , Besides their structural stability enabling multi-usage, many organic catalysts have limited applicability for biological studies.…”

“…9,25 Organic catalyst models generally rely on a fixed active site that is integrated into a given support or cavity, which in turn often limits the capability of these rather rigid structures to remodel enzymatic activity. 10,12 Besides their structural stability enabling multi-usage, many organic catalysts have limited applicability for biological studies.…”