The establishment of KORCC (KOrean Renal Cell Carcinoma) database

Abstract

PurposeThe purpose of this article is to report establishment of the 1st Web-based database (DB) system to collect renal cell carcinoma (RCC) data in Korea.Materials and MethodsThe new Web-based DB system was established to collect basic demographic and clinicopahtological characteristics of a large cohort of patients with RCC in Korea. Data from a total of 6,849 patients were collected from 8 tertiary care hospitals that agreed to participate in organizing the Korean Renal Cell Carcinoma (KORCC) study group as of 1 July 2015. Basic demographic and clinicopathological characteristics were collected. The data of patients who underwent surgical treatments were analyzed to characterize Korean RCC.ResultsWe established the 1st Web-based DB of Korean RCC, a database comprising renal mass management cases from multiple centers in Korea. The data of 5,281 patients who underwent surgical management (mean follow-up, 32 months) were analyzed. The most common symptom was incidentally detected renal mass (76.9%). Clinical T1a was the most common (54.3%) stage and mean tumor size was 4.8±4.2 cm. Radical nephrectomy accounted for 62.7% of cases and an open approach was used in 50.7% and 52.2% of radical and partial nephrectomies, respectively. The 5-year overall, cancer-specific and recurrence-free survival rates were 88.1%, 92.2%, and 88.0%, respectively.ConclusionsWe report the 1st establishment of a Web-based DB system to collect RCC data in Korea. This DB system will provide a solid basis for the characterization of Korean RCC.

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis

“…Furthermore, they only analyzed patients with cRCC. As RCC is a heterogeneous and complex disease [24, 25], its results may not be directly applicable to patients with non-cRCC. In a study of 228 patients with non-mRCC, Jagdev et al [22] reported that NLR was not an independent prognostic factor for disease-free survival.…”

Impact of Young Age at Diagnosis on Survival in Patients with Surgically Treated Renal Cell Carcinoma: a Multicenter Study

“…A database of 7,047 patients with RCC who were treated surgically between 1999 and 2011 at eight academic centers was reviewed. The database listed patient clinicopathologic characteristics including age at diagnosis, gender, body mass index (BMI), comorbidities (diabetes and hypertension), Eastern Cooperative Oncology Group (ECOG) performance status, surgical approach (open vs. laparoscopic), clinical tumor characteristics (tumor location, cTNM stage), tumor pathology (histologic tumor size, pTN stage, Fuhrman nuclear grade, histologic subtype, lymphovascular invasion, and surgical margin status), disease recurrence and site of recurrence (local or metastatic), and information on deaths and their causes (20). Patients with an incomplete data set (n = 1,457) and those with non-RCC pathology or pediatric RCC patients (younger than 18 years) (n = 412) were excluded; the final study group comprised 5,178 patients.…”

Age‐dependent prognostic value of body mass index for non‐metastatic clear cell renal cell carcinoma: A large multicenter retrospective analysis

“…Several epidemiological studies have recently conducted sub‐analyses to better understand obesity paradox, because RCC has a heterogeneous, and complex nature . One meta‐analysis demonstrated that the effects of BMI on CSS and overall survival varied according to tumor stage .…”

“…First, it is the first study to demonstrate the age‐based prognostic value of BMI for RCC, which may improve our understanding of the obesity paradox in predicting RCC prognosis. Second, it included a large multicenter cohort of 2092 patients with nm‐cRCC, which provides clearer information regarding this condition than if we had included patients with all forms and states of RCC, because RCC has a heterogeneous, and complex nature . Third, it considered obesity‐associated factors, such as a diabetes, and hypertension, as well as the most widely accepted prognostic factors for nm‐cRCC .…”

“…These factors might improve our understanding of the prognostic value of obesity for RCC prognosis, although BMI is the most commonly used obesity index in clinical studies and real practice. Finally, we only considered Korean patients, and it is possible that there are ethnic or regional factors that affected our findings, which may not be representative of other ethnic groups and especially Western populations …”