The essential oils of Chamaecyparis obtusa promote hair growth through the induction of vascular endothelial growth factor gene

Lee, Geun‐Shik; Hong, Eui‐Ju; Gwak, Ki-Seob; Park, Mi Jin; Choi, Kyung‐Chul; Choi, In‐Gyu; Jang, Je-Won; Jeung, Eui‐Bae

doi:10.1016/j.fitote.2009.06.016

Cited by 52 publications

(34 citation statements)

References 25 publications

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“…All the animals were housed in polycarbonate cages and acclimated in an environmentally controlled room (23±2˚C; relative humidity, 50±10%; frequent ventilation; and a 12-h light/dark cycle) prior to use as previously described (12). C. obtusa essential oil used in this study was provided by Enbita Co., Ltd. (Seoul, Korea) and was produced through steam distillation of pruned twigs and leaves of the C. obtusa tree, according to previously described methods (13). The rats were treated with C. obtusa essential oil to investigate its effects.…”

Section: Animals and Treatmentmentioning

confidence: 99%

“…Total cellular RNA was extracted using TRIzol reagent (Invitrogen), and the concentration of RNA was determined at 260 nm. RT-PCR was performed as previously described (13). Briefly, total RNA (1 µg) was reverse transcribed into complementary DNA (cDNA) using M-MLV reverse transcriptase (Invitrogen) and a random primer (9-mer; Takara Bio, Inc., Shiga, Japan).…”

Section: Peripheral Blood Mononuclear Cell (Pmnc) Isolationmentioning

confidence: 99%

“…Briefly, total RNA (1 µg) was reverse transcribed into complementary DNA (cDNA) using M-MLV reverse transcriptase (Invitrogen) and a random primer (9-mer; Takara Bio, Inc., Shiga, Japan). The cDNA (1 µl) was used for PCR under standard conditions (13,16); denaturation at 95˚C for 30 sec, annealing at 55˚C for 30 sec and extension at 72˚C for 1 min. The primer sequences used were as follows: COX-2 sense, 5'-TACCCGGACTGGATTCTACG-3' and antisense, 5'-AAGTTGGTGGGCTGTCAATC-3'; TNFα sense, 5'-CTGAGCTCAAGCCCTGGTAT-3' and antisense,…”

Section: Peripheral Blood Mononuclear Cell (Pmnc) Isolationmentioning

confidence: 99%

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Anti-inflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats

Kang

Yang

et al. 2013

Molecular Medicine Reports

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Abstract. Essential oils are concentrated hydrophobic liquids containing volatile aromatic compounds from plants. In the present study, the essential oil of Chamaecyparis obtusa (C. obtusa), which is commercially used in soap, toothpaste and cosmetics, was extracted. Essential oil extracted from C. obtusa contains several types of terpenes, which have been shown to have anti-oxidative and anti-inflammatory effects. In the present study, we examined the anti-inflammatory effects of C. obtusa essential oil in vivo and in vitro following the induction of inflammation by lipopolysaccharides (LPS) in rats. While LPS induced an inflammatory response through the production of prostaglandin E 2 (PGE 2 ) in the blood and peripheral blood mononuclear cells (PMNCs), these levels were reduced when essential oil was pre-administered. Additionally, the mechanism of action underlying the anti-inflammatory effects of C. obtusa essential oil was investigated by measuring the mRNA expression of inflammation-associated genes. LPS treatment significantly induced the expression of transforming growth factor α (TNFα) and cyclooxygenase-2 (COX-2) in rats, while C. obtusa essential oil inhibited this effect. Taken together, our results demonstrate that C. obtusa essential oil exerts anti-inflammatory effects by regulating the production of PGE 2 and TNFα gene expression through the COX-2 pathway. These findings suggest that C. obtusa essential oil may constitute a novel source of anti-inflammatory drugs.

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Section: Animals and Treatmentmentioning

confidence: 99%

Section: Peripheral Blood Mononuclear Cell (Pmnc) Isolationmentioning

confidence: 99%

Section: Peripheral Blood Mononuclear Cell (Pmnc) Isolationmentioning

confidence: 99%

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Anti-inflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats

Kang

Yang

et al. 2013

Molecular Medicine Reports

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“…In the past several years, there have been numerous attempts to develop new agents capable of preventing and/or treating pattern baldness. 3,11,12) Currently, natural extracts from several plants have been used for hair growth promotion, including Asiasari radix, 13) Eclipta alba, 14) essential oil of Chamaecyparis obtuse, 15) Zizyphus jujube, 16) and Sophora flavescens. 12) Rice (Oryza sativa) is one of the most important crops worldwide.…”

mentioning

confidence: 99%

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Choi

Jeon²,

Moon³

et al. 2014

Biological & Pharmaceutical Bulletin

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The potential hair growth-promoting activity of rice bran supercritical CO 2 extract (RB-SCE) and major components of RB-SCE, linoleic acid, policosanol, γ-oryzanol, and γ-tocotrienol, were evaluated with the histological morphology and mRNA expression levels of cell growth factors using real-time reverse transcriptase-polymerase chain reaction (PCR) in C57BL/6 mice. RB-SCE showed hair growth-promoting potential to a similar extent as 3% minoxidil, showing that the hair follicles were induced to be in the anagen stage. The numbers of the hair follicles were significantly increased. In addition, mRNA expression levels of vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), and keratinocyte growth factor (KGF) were also significantly increased and that of transforming growth factor-β (TGF-β) decreased in RB-SCE-treated groups. Among the major components of RB-SCE, linoleic acid and γ-oryzanol induced the formation of hair follicles according to examination of histological morphology and mRNA expression levels of cell growth factors. In conclusion, our results demonstrate that RB-SCE, particularly linoleic acid and γ-oryzanol, promotes hair growth and suggests RB-SCE can be applied as hair loss treatment. Key words rice bran supercritical CO 2 extract; hair growth-promoting activity; in vivoAlthough hair loss is not a mortal disorder, it has a great impact on a person's self-respect, mental health, and overall quality of life. Approximately 50-60 hairs are normally lost per day, which does not have a noticeable effect on appearance; however, excess loss (>100) results in baldness. Androgenetic alopecia is the most common type of hair loss, affecting millions of both men and women.1) There are many causes of hair loss in men and women, including diseases, nutritional deficiency, aging, hormone imbalance, and stress. Androgenetic alopecia may occur as early as the teenage years, but typically begin in the later decades of life. 2,3) Hair loss affects at least half of all men by the age of 50 and up to 70% of 70-year-old men. 4)

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“…In addition, it suggested that HGF could promote the hair follicles growth of newborn mice and the hair follicle would become longer and larger in histology when the mice was injected HGF in the dorsal skin subcutaneously (Fushimi et al, 2011). Lee showed that epithin/matriptase (Epi/MTP) which played a significant role in mammary epithelial cell growth and morphogenesis participated in mammary epithelial growth and modeling through activation of pro-HGF (Lee et al, 2010a).…”

Section: Hepatocyte Growth Factor (Hgf)mentioning

confidence: 99%

Progress in Relevant Growth Factors Promoting the Growth of Hair Follicle

Valerie¹

2012

American Journal of Animal and Veterinary Sciences

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Abstract:Hair is a protective appendage on the body that is considered accessory structure of the integument. Hair follicle development takes place during fetal skin development and relies on tightly regulated ectodermal-mesodermal interactions. The morphological changes of the hair cycle have been very clear that hair morphogenesis and epidermal development are orchestrated by an array of growth factors. In this review, we summarize the major growth factors involved in promoting growth of hair follicles.

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The essential oils of Chamaecyparis obtusa promote hair growth through the induction of vascular endothelial growth factor gene

Cited by 52 publications

References 25 publications

Anti-inflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats

Anti-inflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Progress in Relevant Growth Factors Promoting the Growth of Hair Follicle

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