The Essential Oil of Zingiberaceae Leaf as Antioxidant and Antiglycation

Batubara, Irmanida; Zahra, Ummi; Darusman, Latifah Kosim; Maddu, Akhirudin

doi:10.21776/ub.ijeo.2016.001.01.05

Cited by 12 publications

(9 citation statements)

References 16 publications

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“…Indeed, some previous studies reported antiglycation activity from plant extracts. Crude extracts from Zingiber zerumbet and essential oil of Zingiber officinale were reported to possess antiglycation activity with IC 50 values of 377.95 and 207.95 µg/ml, respectively [17,25] . In this context, the extract PTR-21 exhibited IC 50 value that was 0.25 to 2-fold higher than other extracts.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, Antiglycation and in vivo Antiaging Effects of Metabolite Extracts from Marine Sponge-associated Bacteria

Prastya¹,

Astuti²,

Batubara³

et al. 2019

pharmaceutical-sciences

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Marine sponges are evolutionary multicellular organisms that have been reported as the best producers of bioactive compounds, which have antibacterial, antifungal, anticancer and cytotoxic properties [1] . The limitations of sponge biomass and ecological problems such as marine environmental damage and sponge extinction are the main factor for isolating the large scale bioactive compounds. Interestingly, a previous research showed that 40-60 % of sponge biomass is symbiotic microorganisms that can produce metabolite compounds similar to those produced by the host. It is hypothesized that symbiotic marine-microorganisms harbored by sponges are the original producers of these bioactive compounds [2] . Previous studies had revealed the antioxidant and anticancer activity of bacterial crude extracts isolated from sponge Jaspis sp. against human cervix HeLa cells and leukemic cell lines [3,4] . In addition, crude extract of Bacillus sp. isolated from sponge Haliclona sp. was also reported to have anticancer activity against MOLT4 cells and its activity is related to NRPS-PKS genes to encode the bioactive compounds [5] .Antioxidant activity plays an important role in cellular physiology as it has the ability to neutralize and prevent free radicals, including reactive oxygen species (ROS) and its derivatives, from damaging cells. However, an imbalance between ROS production and antioxidant defence may lead to oxidative stress, which may cause degenerative diseases such as cancer, Alzheimer's, cardiovascular, aging and neurological disorders [6] .

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Section: Resultsmentioning

confidence: 99%

Antioxidant, Antiglycation and in vivo Antiaging Effects of Metabolite Extracts from Marine Sponge-associated Bacteria

Prastya¹,

Astuti²,

Batubara³

et al. 2019

pharmaceutical-sciences

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“…Five different Zingiberaceae plants as shown in Table 1 were selected. The essential oils from the leaves of these plants have been reported to show antioxidant, antiglycation, and antibacterial activity against S. mutans as well as demonstrate the ability to degrade the biofilm produced by S. mutans [1,2]. As previously mentioned, the distillation process not only produces essential oils but also residue.…”

Section: Name Of Plants Moisture Content and Ash Content Of Samplesmentioning

confidence: 91%

“…People have used this family of plant to cure various diseases such as fever, skin diseases, digestive disorders, and respiratory disorders. The rhizome is the most used part of this plant, while the leaves had been reported to have high content of essential oils and shown tyrosinase inhibition, antioxidant, antiglycation, and antimicrobial activities [1,2]. Antioxidant and antiglycation are important for health and often associated with antiaging.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Biofilm Degradation Activity of Extract From Steam Distillation Residue of Zingiberaceae Leaves Against Streptococcus mutans

Batubara

Yunita

Suparto³

2019

J. Idn. Chem. Soc.

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Zingiberaceae is a family of plant that has been widely used to treat various diseases and as an element of spice in cooking. In this paper, the potential of the extract from the steam distillation residue of Zingiberaceae leaves as antibacterial and biofilm degradation agent was studied and determined against Streptococcus mutans. Five different species of Zingiberaceae, which consisted of Curcuma longa, Curcuma zeodoaria, Curcuma aeruginosa, Zingiber officinale, Zingiber cassumunar were taken for samples and their distillation residues were extracted by soxhlation using 3 different solvents namely n-hexane, ethyl acetate, and methanol. The antibacterial and biofilm degradation activity of the assay from each of the samples was determined by the microdilution technique. Among the 15 Zingiberaceae leaves distillation residue extracts, five are categorically active against Streptococcus mutans with their minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values being the same with that of chloramphenicol, 15.63 μg/mL. All extracts were found to degrade the biofilm. The methanol extract of C. zeodoaria leaves was found to have the highest antibacterial activity with MIC and MIB vaues of 15.63 ppm and the best to degrade the biofilm with inhibitory concentration 50% (IC50) of 15.33 ppm. The antibacterial and biofilm degradation activities of extracts are not related to the phenolic content and it was suggested that terpenoid such as (-)-zingiberene may have been the active component.

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“…Antioxidant activities of fractions were measured based on the radical scavenging activity toward 2,2′-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS), as described previously [ 18 , 19 ]. The antiglycation reactions were carried out by mixing fractions in solution and the glycation substrate based on a previous method [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

The Antiaging Effect of Active Fractions and Ent-11α-Hydroxy-15-Oxo-Kaur-16-En-19-Oic Acid Isolated from Adenostemma lavenia (L.) O. Kuntze at the Cellular Level

et al. 2020

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Background: The extract of Adenostemma lavenia (L.) O. Kuntze leaves has anti-inflammatory activities and is used as a folk medicine to treat patients with hepatitis and pneumonia in China and Taiwan. The diterpenoid ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid (11αOH-KA) is the major ingredient in the extract and has wide-spectrum biological activities, such as antitumor and antimelanogenic activities, as well as anti-inflammatory activity. However, the physical and biological properties of this compound as an antioxidant or antiaging agent have not been reported yet. Methods: In addition to in vitro assays, we monitored antioxidative and antiaging signals in Schizosaccharomyces pombe (yeast) and mouse melanoma B16F10 cells. Results: A. lavenia water and chloroform fractions showed antioxidant properties in vitro. The A. lavenia extracts and 11αOH-KA conferred resistance to H2O2 to S. pombe and B16F10 cells and extended the yeast lifespan in a concentration-dependent manner. These materials maintained the yeast mitochondrial activity, even in a high-glucose medium, and induced an antioxidant gene program, the transcriptional factor pap1+ and its downstream ctt1+. Accordingly, 11αOH-KA activated the antioxidative transcription factor NF-E2-related factor 2, NRF2, the mammalian ortholog of pap1+, in B16F10 cells, which was accompanied by enhanced hemeoxygenase expression levels. These results suggest that 11αOH-KA and A. lavenia extracts may protect yeast and mammalian cells from oxidative stress and aging. Finally, we hope that these materials could be helpful in treating COVID-19 patients, because A. lavenia extracts and NRF2 activators have been reported to alleviate the symptoms of pneumonia in model animals.

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The Essential Oil of Zingiberaceae Leaf as Antioxidant and Antiglycation

Cited by 12 publications

References 16 publications

Antioxidant, Antiglycation and in vivo Antiaging Effects of Metabolite Extracts from Marine Sponge-associated Bacteria

Antioxidant, Antiglycation and in vivo Antiaging Effects of Metabolite Extracts from Marine Sponge-associated Bacteria

Antibacterial and Biofilm Degradation Activity of Extract From Steam Distillation Residue of Zingiberaceae Leaves Against Streptococcus mutans

The Antiaging Effect of Active Fractions and Ent-11α-Hydroxy-15-Oxo-Kaur-16-En-19-Oic Acid Isolated from Adenostemma lavenia (L.) O. Kuntze at the Cellular Level

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