The essential metals for humans: a brief overview

Zoroddu, Maria Antonietta; Aaseth, Jan; Crisponi, Guido; Medici, Serenella; Peana, Massimiliano; Nurchi, Valeria Marina

doi:10.1016/j.jinorgbio.2019.03.013

Cited by 590 publications

(242 citation statements)

References 81 publications

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“…The concentration of ions in the environment determines whether it has an inactive, destructive, or stimulating effect on various types of cells. Copper is an element necessary for the proper functioning of all cells [90]. For example, it should be delivered to the human body (an adult, weighing about 70 kg) at a dose of about 1.35 mg/day [91].…”

Section: Discussionmentioning

confidence: 99%

Influence of Material Composition on Structure, Surface Properties and Biological Activity of Nanocrystalline Coatings Based on Cu and Ti

et al. 2020

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In this paper, the influence of material composition on structure and surface properties of bioactive coatings based on Cu and Ti is described. Nanocrystalline coatings were prepared by innovative pulsed DC magnetron sputtering. For their preparation, a multi-magnetron system was used in order to obtain films with various copper content. The main goal of our work was the complex analysis of biological activity of Cu-Ti films in comparison with their material composition and surface state. Antimicrobial activity (for E. coli and S. aureus), as well as the impact on cell viability (L929 line), were investigated. The physicochemical properties were examined with the aid of X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, and atomic absorption spectroscopy. It was found that all prepared films were nanocrystalline and bactericidal, but their cytotoxicity was related to the Cu-content in the film. Complex analysis of the bioactivity was developed in relation to the copper ion migration process. Moreover, manufacturing of antibacterial films with stimulating action on L929 cell line was possible.

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Section: Discussionmentioning

confidence: 99%

Influence of Material Composition on Structure, Surface Properties and Biological Activity of Nanocrystalline Coatings Based on Cu and Ti

et al. 2020

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“…The essential metals play a key role in the physiological and biochemical processes in plants and animals. Metals such are Na, K, Mg, Ca, Fe, Mn, Co, Cu, Zn and Mo have been identified as essential elements for life and body of human beings [12]. However, at certain concentrations, both essential and non-essential metals can be toxic to living organisms [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Spatial and temporal distribution and contamination assessment of heavy metal in Woji Creek

Dibofori-Orji¹,

Ihunwo

Udo

et al. 2019

Environ. Res. Commun.

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Land use is one major factor that affects river water quality which is related to anthropogenic activities. Studies have shown that abandoned boats on watershed, petroleum and untreated wastewater from abattoirs can lead to anthropogenic pollution in surface waters. This study, therefore, was designed to assess spatial and temporal variation of selected heavy metals and level of pollution in Woji Creek. The study was carried out in the months of August, September and October 2018. Water samples were collected from five stations along the creek over a 3.2 km stretch. Water was collected to be analysed for heavy metals (Nickel, Cadmium, Copper, Lead and Iron). Results were subjected to ANOVA and heavy metal pollution index (HPI) was calculated using aquatic toxicity reference values (TRV) as threshold values. Heavy metal dominance in Woji was in the order of Pb>Ni>Fe>Cd>Cu. In the river, Ni had mean values ranging from 0.379±0.259 mg l −1 in August to 0.545±0.369 in October, while Pb with the highest concentration had mean values ranging from 0.229±0.333 mg l −1 in October to 1.534±0.103 mg l −1 in September. Concentrations of metals analysed were high than the TRV. Temporal analysis of HPI calculated for the study was above the critical heavy metal pollution index (100) (August=329.358, September=361.796, October=112.715). A correlation was observed between heavy metals analysed during the study. Spatial analysis of HPI showed higher pollution level at Station 3 with the highest anthropogenic activity along the creek. Cu showed a negative correlation to other metals analysed. Sources of pollution on this creek was identified to be both natural and majorly anthropogenic sources. This study, therefore, points out the need for proper environmental management as regards commercial activities around the waterways.

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“…As BAL and DMSA, also DMPS enhance Cu and Zn urinary excretion, which in some patients give deficiency symptoms (Flora and Pachauri 2010;Kosnett 2004). The trace elements Cu and Zn are both antagonists in function and essential for living cells (Bjørklund 2013;Chasapis et al 2012;Zoroddu et al 2019). Consequently, monitoring their concentrations during chelation treatment is required .…”

Section: Dmpsmentioning

confidence: 99%

“…As in trace amounts is an essential nutrient for energy generation in prokaryotes and several eukaryotes, including birds and mammals. It is also possible that As is an essential trace element for humans, although its role in metabolism has not been clearly defined (Oremland and Stolz 2003;Uthus 1992;Zoroddu et al 2019). The human body contains approximately 0.08-0.02 mg As/kg, which mainly is concentrated in liver, kidneys, lungs, bones, and hair.…”

Section: Introductionmentioning

confidence: 99%

Arsenic intoxication: general aspects and chelating agents

et al. 2020

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Arsenic (As) is widely used in the modern industry, especially in the production of pesticides, herbicides, wood preservatives, and semiconductors. The sources of As such as contaminated water, air, soil, but also food, can cause serious human diseases. The complex mechanism of As toxicity in the human body is associated with the generation of free radicals and the induction of oxidative damage in the cell. One effective strategy in reducing the toxic effects of As is the usage of chelating agents, which provide the formation of inert chelator-metal complexes with their further excretion from the body. This review discusses different aspects of the use of metal chelators, alone or in combination, in the treatment of As poisoning. Consideration is given to the therapeutic effect of thiol chelators such as meso-2,3-dimercaptosuccinic acid, sodium 2,3-dimercapto-1-propanesulfonate, 2,3-dimercaptopropanol, penicillamine, ethylenediaminetetraacetic acid, and other recent agents against As toxicity. The review also considers the possible role of flavonoids, trace elements, and herbal drugs as promising natural chelating and detoxifying agents.

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The essential metals for humans: a brief overview

Cited by 590 publications

References 81 publications

Influence of Material Composition on Structure, Surface Properties and Biological Activity of Nanocrystalline Coatings Based on Cu and Ti

Influence of Material Composition on Structure, Surface Properties and Biological Activity of Nanocrystalline Coatings Based on Cu and Ti

Spatial and temporal distribution and contamination assessment of heavy metal in Woji Creek

Arsenic intoxication: general aspects and chelating agents

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