The essential chaperone DNAJC17 activates HSP70 to coordinate RNA splicing and G2-M progression
David V. Allegakoen,
Kristen Kwong,
Jacqueline Morales
et al.
Abstract:Molecular chaperones including the heat-shock protein 70-kilodalton (HSP70) family and the J-domain containing protein (JDP) co-chaperones maintain homeostatic balance in eukaryotic cells through regulation of the proteome. The expansive JDP family helps direct specific HSP70 functions, and yet loss of single JDP-encoding genes is widely tolerated by mammalian cells, suggesting a high degree of redundancy. By contrast, essential JDPs might carry out HSP70-independent functions or fill cell-context dependent, h… Show more
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