The EsophyX Endoluminal Fundoplication Device for GORD: The First Patients from the United Kingdom

Youd, Philippa; Emmanuel, Anton; Gould, Stuart; Arebi, Naila; Gurmany, Salma; Fraser, Chris

doi:10.1016/j.gie.2007.03.1003

Cited by 1 publication

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“…Both studies, although they were small and had only short-term follow-up, demonstrated very encouraging results, with the majority of patients off antireflux medication following the procedure. 16,17 The largest reported series is a prospective multicenter trial by Cadière et al 9 in which 86 patients with GERD underwent endolumenal fundoplication using the first-generation EsophyX device. Of these, 59 patients had 1 to 3 cm hiatal hernias that were all reduced, based on endoscopic appearance, at the time of the procedure.…”

Section: Discussionmentioning

confidence: 99%

Endolumenal Fundoplication With EsophyX: The Initial North American Experience

et al. 2008

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EsophyX is a novel endolumenal therapeutic option for the treatment of gastroesophageal reflux disease (GERD). The device is passed into the stomach, where it deploys a series of full-thickness fasteners to create a neogastroesophageal valve. The objective of this study was to demonstrate the safety and characterize the effectiveness of this approach in the initial North American experience. This is a retrospective study of consecutive patients with GERD who had undergone endolumenal fundoplication with the EsophyX device. At follow-up, proton pump inhibitor usage was elicited and 2 validated questionnaires were administered measuring GERD health-related quality of life (range 0-50) and symptom severity (range 0-72). In limited preliminary evaluation, the initial North American experience with endolumenal fundoplication using the EsophyX device is that it appears to be safe and provides moderate effectiveness in treating the symptoms of GERD. Further studies comparing this technique with conventional medical and surgical therapies are necessary.

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Section: Discussionmentioning

confidence: 99%