The esophagogastric junction in patients with asymptomatic lower esophageal mucosal rings

Eckardt, V.; Adami, Bernd; Hücker, H; Leeder, H.

doi:10.1016/0016-5085(80)90366-2

Cited by 26 publications

(3 citation statements)

References 23 publications

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“…Prospective studies have documented an association with reflux in fewer than two thirds of patients with SR (2,4,8). Patients with SR have a normal lower esophageal sphincter pressure, suggesting that SR does not develop in the setting of prolonged lower esophageal sphincter hypotension (16–18). In addition, the presence of esophageal inflammation varies from 27% to 45% (18,19), and studies using pH monitoring to correlate the presence of excess acid in the esophagus with SR have been unsuccessful (3).…”

Section: Discussionmentioning

confidence: 99%

Association of Schatzki Ring With Eosinophilic Esophagitis in Children

Nurko,

Teitelbaum,

Husain

et al. 2004

J. pediatr. gastroenterol. nutr.

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Objective:To describe the clinicopathologic characteristics of children with Schatzki ring and to determine if Schatzki ring is associated with eosinophilic esophagitis.Methods:The authors report 18 adolescents with radiographically diagnosed Schatzki ring (SR). Their clinical and histologic characteristics were reviewed in a blinded fashion.Results:The mean age of the patients was 15.8 ± 0.8 years and mean duration of symptoms was 2.6 ± 0.4 years. By histologic criteria, two groups of patients were defined. Eight had clinical and histologic criteria of eosinophilic esophagitis (EE) and 10 of peptic esophagitis. There were no differences in the symptoms or radiographic findings in the two groups. The SR was not identified by endoscopy in any EE patient and was identified in 70% of peptic esophagitis patients. Grossly apparent mucosal features associated with EE were significantly more common in those with EE. Those with peptic esophagitis had a significantly higher acid exposure than did those with EE (12.6 ± 2.9 v 2.0 ± 1.1%; P < 0.01) by esophageal pH probe. Patients with peptic esophagitis responded to proton pump inhibitors and/or dilatation, whereas those with EE did not have good response and required specific therapy for EE.Conclusions:EE may play a role in the pathogenesis of some patients with SR.

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Section: Discussionmentioning

confidence: 99%

Association of Schatzki Ring With Eosinophilic Esophagitis in Children

Nurko,

Teitelbaum,

Husain

et al. 2004

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

show abstract

“…Prospective studies have documented an association with reflux in fewer than two thirds of patients with SR (2,4,8). Patients with SR have a normal lower esophageal sphincter pressure, suggesting that SR does not develop in the setting of prolonged lower esophageal sphincter hypotension (16)(17)(18). In addition, the presence of esophageal inflammation varies from 27% to 45% (18,19), and studies using pH monitoring to correlate the presence of excess acid in the esophagus with SR have been unsuccessful (3).…”

Section: Discussionmentioning

confidence: 99%

Clinical Quiz

Teitelbaum

2004

J. pediatr. gastroenterol. nutr.

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“…So when C astiglione et al (2) suggest that meals should be standardized during esophageal pH monitoring, because the number of reflux episodes are dependent on meal composition, registration of reflux episodes can apparently also be influenced by ordinary life style, i.e., body position, talking, and swallowing. This does not appear to be of any significance in clinical investigations, but in experimental settings it can probably explain some of the results of E ckardt et al (3), where they describe a technique for simultaneous measurements of transmural electric potential difference (PD) and intraluminal pressure, thus making it possible to identify the location of the squamo‐columnar junction and the LES simultaneously. They found that intragastric potentials were always more lumen negative than the intraesophageal potentials, and after positioning the electrode in the PD transitional zone in the gastroesophageal junction, they observed that swallowing was associated with a brief oscillation in PD, whereas breathing had no effect on transmural electric PD.…”

Section: Discussionmentioning

confidence: 99%