The equine immune responses to infectious and allergic disease: A model for humans?

Horohov, David W.

doi:10.1016/j.molimm.2014.09.020

Cited by 29 publications

(23 citation statements)

References 171 publications

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“…Lack of upregulation of miR-146a and miR-146b could represent a weakness of an equine model such as this, although this is potentially consistent with some human models using patient-sourced cells [46] as opposed to cell lines. Nonetheless, valuable insight can be gained from the comparative study of naturally-occurring disease between species, and the equine model offers a unique addition to the tool box of options for exploration of events that orchestrate the inflammatory cascade directing life-threatening endotoxemia and septic shock [70]. …”

Section: Discussionmentioning

confidence: 99%

Characterization of basal and lipopolysaccharide-induced microRNA expression in equine peripheral blood mononuclear cells using Next-Generation Sequencing

et al. 2017

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The innate immune response to lipopolysaccharide contributes substantially to the morbidity and mortality of gram-negative sepsis. Horses and humans share an exquisite sensitivity to lipopolysaccharide and thus the horse may provide valuable comparative insights into this aspect of the inflammatory response. MicroRNAs, small non-coding RNA molecules acting as post-transcriptional regulators of gene expression, have key roles in toll-like receptor signaling regulation but have not been studied in this context in horses. The central hypothesis of this study was that lipopolysaccharide induces differential microRNA expression in equine peripheral blood mononuclear cells in a manner comparable to humans. Illumina Next Generation Sequencing was used to characterize the basal microRNA transcriptome in isolated peripheral blood mononuclear cells from healthy adult horses, and to evaluate LPS-induced changes in microRNA expression in cells cultured for up to four hours. Selected expression changes were validated using quantitative reverse-transcriptase PCR. Only miR-155 was significantly upregulated by LPS, changing in parallel with supernatant tumor necrosis factor-α concentration. Eight additional microRNAs, including miR-146a and miR-146b, showed significant expression change with time in culture without a clear LPS effect. Target predictions indicated a number of potential immunity-associated targets for miR-155 in the horse, including SOCS1, TAB2 and elements of the PI3K signaling pathway, suggesting that it is likely to influence the acute inflammatory response to LPS. Gene alignment showed extensive conservation of the miR-155 precursor gene and associated promoter regions between horses and humans. The basal and LPS-stimulated microRNA expression pattern characterized here were similar to those described in human leukocytes. As well as providing a resource for further research into the roles of microRNAs in immune responses in horses, this will facilitate inter-species comparative study of the role of microRNAs in the inflammatory cascade during endotoxemia and sepsis.

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Section: Discussionmentioning

confidence: 99%

Characterization of basal and lipopolysaccharide-induced microRNA expression in equine peripheral blood mononuclear cells using Next-Generation Sequencing

et al. 2017

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“…Severe equine asthma, also known as heaves, RAO (recurrent airway obstruction), or SPAOPD (summer-pasture associated obstructive pulmonary disease) is a spontaneously occurring disease of horses and a recognized model for human asthma [ 19 , 172 , 173 ]. Among the equine asthma phenotypes ( Figure 3 ), the severe form describes horses that are experiencing episodes of dyspnea at rest triggered by hay dust antigens and reversible with the administration of bronchodilators, in the absence of infections.…”

Section: Severe Equine Asthma: a Model Of Oxi-inflamm-agingmentioning

confidence: 99%

The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma

Bullone

Lavoie

2017

IJMS

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Aging is associated with a dysregulation of the immune system, leading to a general pro-inflammatory state of the organism, a process that has been named inflamm-aging. Oxidative stress has an important role in aging and in the regulation of immune responses, probably playing a role in the development of age-related diseases. The respiratory system function physiologically declines with the advancement of age. In elderly asthmatic patients, this may contribute to disease expression. In this review, we will focus on age-related changes affecting the immune system and in respiratory structure and function that could contribute to asthma occurrence, and/or clinical presentation in the elderly. Also, naturally occurring equine asthma will be discussed as a possible model for studying the importance of oxidative stress and immun-aging/inflamm-aging in humans.

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“…The equine immune system can mount a strong immune response against many viral pathogens, resulting their successful elimination and resolution of infection [17][18][19]. Similarly, both natural and experimental EAV infection induces a solid and durable immune response that protects horses against subsequent infections [14,20].…”

Section: Eav Persistent Infection In the Stallionmentioning

confidence: 99%

Host Factors that Contribute to Equine Arteritis Virus Persistence in the Stallion: an Update

Balasuriya

Sarkar

Carossino

et al. 2016

Journal of Equine Veterinary Science

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The equine immune responses to infectious and allergic disease: A model for humans?

Cited by 29 publications

References 171 publications

Characterization of basal and lipopolysaccharide-induced microRNA expression in equine peripheral blood mononuclear cells using Next-Generation Sequencing

Characterization of basal and lipopolysaccharide-induced microRNA expression in equine peripheral blood mononuclear cells using Next-Generation Sequencing

The Contribution of Oxidative Stress and Inflamm-Aging in Human and Equine Asthma

Host Factors that Contribute to Equine Arteritis Virus Persistence in the Stallion: an Update

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