The Epithelial-to-Mesenchymal Transition Supports HCMV Infection and Biosynthesis in Mammary Epithelial Cells Through Two Distinct Mechanisms
Preethi Golconda,
Mariana Andrade-Medina,
Rachel Matrenec
et al.
Abstract:Human cytomegalovirus (HCMV) infects a wide range of cell types in the body, including a variety of epithelial cell types. Despite the significance of epithelial cells during infection, HCMV has been difficult to study in epithelial cells. In this study, we examined HCMV infection in mammary and prostate epithelial cell lines, finding that the virus establishes a semi-permissive, biosynthetically abortive state. Building on previous work, we hypothesized that shifting epithelial cells to a mesenchymal cell sta… Show more
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