The epigenome of male germ cells and the programming of phenotypes in cattle

Kiefer, Hélène; Sellem, Eli; Bonnet-Garnier, Amélie; Pannetier, Maëlle; Costes, Valentin; Schibler, Laurent; Jammes, Hélène

doi:10.1093/af/vfab062

Cited by 8 publications

(4 citation statements)

References 62 publications

(79 reference statements)

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“…Sperm epigenomes (e.g., DNA methylation, chromatin-associated proteins and non-coding RNAs) will be partly transmitted to the embryo, leading to the so-called intergenerational and transgenerational epigenetic inheritance, to influence the early development and health of offspring [ 2 ]. Furthermore, selection, breeding, and semen processing practices for AI may potentially cause epigenetic alterations of sperms, whereas other practices like embryo technology or hormonal treatments may influence sperm epigenome in the long-term period [ 3 ]. Undoubtedly, the understanding of bovine sperm epigenome and the identification of epigenetic biomarkers of sperm quality can help the selection of superior bulls in terms of both male fertility and genetic values of other economic traits reflected in the offspring (e.g., milk production and health) [ 4 – 6 ].…”

Section: The Epigenome Of Bovine Spermmentioning

confidence: 99%

“…2 ). The toroid-shaped structure of DNA is finally formed with arginine-rich protamines to enable a higher level of chromatin compaction [ 3 ], which helps to reduce nuclear volume and avoids oxidation during migration for fertilization of an oocyte. Therefore, spermatozoa are usually transcriptionally inactive, and their epigenome is unique as the ultimate form of male germ cell differentiation [ 16 ].…”

Section: The Epigenome Of Bovine Spermmentioning

confidence: 99%

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Harnessing male germline epigenomics for the genetic improvement in cattle

Wang

Feng

et al. 2023

J Animal Sci Biotechnol

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Sperm is essential for successful artificial insemination in dairy cattle, and its quality can be influenced by both epigenetic modification and epigenetic inheritance. The bovine germline differentiation is characterized by epigenetic reprogramming, while intergenerational and transgenerational epigenetic inheritance can influence the offspring’s development through the transmission of epigenetic features to the offspring via the germline. Therefore, the selection of bulls with superior sperm quality for the production and fertility traits requires a better understanding of the epigenetic mechanism and more accurate identifications of epigenetic biomarkers. We have comprehensively reviewed the current progress in the studies of bovine sperm epigenome in terms of both resources and biological discovery in order to provide perspectives on how to harness this valuable information for genetic improvement in the cattle breeding industry.

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Section: The Epigenome Of Bovine Spermmentioning

confidence: 99%

Section: The Epigenome Of Bovine Spermmentioning

confidence: 99%

Harnessing male germline epigenomics for the genetic improvement in cattle

Wang

Feng

et al. 2023

J Animal Sci Biotechnol

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“…The programming role of the paternal environment has been revealed in the past decade, with effects of paternal nutrition or exposure to environmental disruptors being reported in their offspring for several generations (Oshio et al, 2020;Soubry, 2018aSoubry, , 2018b. Briefly, genome-wide erasure and re-apposition of DNA methylation take place during pregnancy in the foetal male primordial germ cells and pro-spermatogonia, with different timing relative to conception in mice and cattle (Kiefer et al, 2021). This is an important window of epigenetic plasticity that can be altered by gestational conditions, with modifications of the sperm methylome that in mice have been shown to affect subsequent offspring fertility (Lambrot et al, 2013) and metabolism (Martinez et al, 2014).…”

Section: Paternalenvironmentmentioning

confidence: 99%

Intra‐uterine programming of future fertility

Chavatte‐Palmer,

Couturier‐Tarrade,

Rousseau‐Ralliard

2023

Reprod Domestic Animals

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The developmental origins of health and disease (DOHaD) shows that a relationship exists between parental environment at large, foeto‐placental development and the risk for the offspring to develop non‐transmittable disease(s) in adulthood. This concept has been validated in both humans and livestock. In mammals, after fertilization and time spent free in the maternal reproductive tract, the embryo develops a placenta that, in close relationship with maternal endometrium, is the organ responsible for exchanges between dam and foetus. Any modification of the maternal environment can lead to adaptive mechanisms affecting placental morphology, blood flow, foetal‐maternal exchanges (transporters) and/or endocrine function, ultimately modifying placental efficiency. Among deleterious environments, undernutrition, protein restriction, overnutrition, micronutrient deficiencies and food contaminants can be outlined. When placental adaptive capacities become insufficient, foetal growth and organ formation is no longer optimal, including foetal gonadal formation and maturation, which can affect subsequent offspring fertility. Since epigenetic mechanisms have been shown to be key to foetal programming, epigenetic modifications of the gametes may also occur, leading to inter‐generational effects. After briefly describing normal gonadal development in domestic species and inter‐species differences, this review highlights the current knowledge on intra‐uterine programming of offspring fertility with a focus on domestic animals and underlines the importance to assess transgenerational effects on offspring fertility at a time when new breeding systems are developed to face the current climate changes.

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“…In summary, in the sperm chromatin is happening some sequenced events: heat stress negatively modifies gene and protein expression which arises ROS production resulting in oxidative damage (Garcia-Oliveros et al, 2020). Nevertheless, those stimuli are suggested to cause marks along the sperm epigenome, reflected in increased DNA methylation, altered nucleoprotein substitution, male pronucleus delay, and final impairment in embryo development (Rahman et al, 2014;Kiefer et al, 2021). The resulting epigenetic profile varies among individuals, because of the degree of susceptibility to external or noxious stimuli.…”

Section: Oxidative and Heat Stressmentioning

confidence: 99%

What is known so far about bull sperm protamination: a review

2022

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Sperm routinary fitness evaluation is not sufficient to predict bull reproductive capacity as they present differences in fertility up to 40%. Among the defects which compromise spermatozoa functionality, new approaches consider the study of sperm chromatin, which is the core structure containing paternal genetic information. Sperm chromatin needs to be compacted to maintain the integrity of DNA, which occurs by binding nucleoproteins with high affinity to DNA. In the last stages of sperm maturation, chromatin is hyper-compacted by basic proteins called protamines in a process named protamination. In this review, we summarized intrinsic and extrinsic factors that are suggested to influence protamination in bull spermatozoa, considering old and new evidence from human and murine spermatozoa. Also, the current approaches to evaluate bull protamination and its relationship with fertility were described. Nevertheless, the physiological mechanisms of protamination are still poorly understood.

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The epigenome of male germ cells and the programming of phenotypes in cattle

Cited by 8 publications

References 62 publications

Harnessing male germline epigenomics for the genetic improvement in cattle

Harnessing male germline epigenomics for the genetic improvement in cattle

Intra‐uterine programming of future fertility

What is known so far about bull sperm protamination: a review

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