Abstract:Interest in epigenetics has gained substantial momentum as a result of their identified role in the regulation of tumor progression, as well as their ability to pharmacologically target genes. Pituitary Neuroendocrine tumors (PitNETs) tend to be inactivated via epigenetic modification, and although emerging evidence has suggested a role for epigenetic factors in PitNET tumorigenesis, the degree to which these factors may be targeted by new therapeutic strategies still remains poorly understood. The objective o… Show more
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