The epidermal growth factor receptor is associated with phospholipase C-γ1 in meningiomas

Johnson, Mahlon D.; Horiba, Megumi; Winnier, Angela R.; Arteaga, Carlos L.

doi:10.1016/0046-8177(94)90270-4

Cited by 48 publications

(26 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown previously that PLCg is involved in epidermal growth factor receptor -mediated growth stimulation in benign human meningiomas (22). In contrast, the role of PLCg in atypical and anaplastic meningiomas has not been determined.…”

Section: Discussionmentioning

confidence: 95%

“…It has been well established that the growth factor -mediated activation of intracellular signaling cascades contributes to meningioma proliferation (13,15,16,22). However, most of these studies investigated benign WHO grade 1 tumors or primary cell cultures derived from such tumors, but the role of signaling cascade activation in atypical or malignant meningiomas remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Different Activation of Mitogen-Activated Protein Kinase and Akt Signaling Is Associated with Aggressive Phenotype of Human Meningiomas

Mawrin

Sasse

Kirches

et al. 2005

Clinical Cancer Research

117

View full text Add to dashboard Cite

Purpose: Activation of intracellular signaling cascades has been implicated in the growth control of benign meningiomas, but their role for meningioma progression and outcome is unknown. Here we determined the expression and function of proteins involved in mitogenactivated protein kinase (MAPK) and phosphinositol-3 kinase (PI3K)/Akt signaling in benign, atypical, and malignant meningiomas and studied their association with clinicopathologic data including meningioma recurrence. Experimental Design: Expression of various MAPK and PI3K signaling proteins was determined in 70 primary meningiomas and, if present, in recurrent tumors by immunohistochemistry andWestern blotting.The expression patterns in primary and recurrent tumors were related to clinical data.The effect of MAPK and PI3K pathway inhibition on cell proliferation and apoptosis was determined using a primary malignant meningioma cell culture. Results: Atypical and malignant meningiomas showed higher levels of phospho-Akt compared with benign tumors, and their proliferation could be inhibited by PI3K blocking using wortmannin. PI3K inhibition did not induce apoptosis in malignant meningioma cells. In contrast, expression of phospho-Raf and phospho-MAPK was decreased in aggressive meningiomas compared with benign tumors, but MAPK inhibition by PD98059 resulted in tumor cell apoptosis and decreased proliferation. Reduced MAPK activation was associated with meningioma recurrence, and PI3K activation was associated with poor preclinical condition and brain invasion of malignant meningiomas. Conclusions: Both MAPK and PI3K/Akt pathways are activated at different levels in benign and malignant meningiomas. Activation of PI3K/Akt signaling contributes to the aggressive behavior of malignant meningiomas, whereas MAPK activation is involved in both proliferation and apoptosis of malignant meningiomas.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Different Activation of Mitogen-Activated Protein Kinase and Akt Signaling Is Associated with Aggressive Phenotype of Human Meningiomas

Mawrin

Sasse

Kirches

et al. 2005

Clinical Cancer Research

117

View full text Add to dashboard Cite

show abstract

“…Both EGF and its receptor, EGFR, have been implicated in meningioma tumorigenesis. 1,2,4,[6][7][8]10,11,13,[16][17][18]20,28,37,40,41 Reports vary on the incidence of EGFR expression in meningiomas, with reported incidences ranging from 33 to 100%. 10,13 In the majority of studies, the incidence was placed in the range of 50 to 60%.…”

Section: Immunohistochemical Analysis Of Egfr Expressionmentioning

confidence: 99%

Association between absence of epidermal growth factor receptor immunoreactivity and poor prognosis in patients with atypical meningioma

Smith

Lal²,

Harmon-Smith³

et al. 2007

JNS

View full text Add to dashboard Cite

show abstract

“…[4,5] Weisman, et al [6] characterized expression of EGFR in meningiomas and suggested that EGFR is involved in the proliferation and/or differentiation of meningothelial cells. Although, there are a few studies from the west [7][8][9] on the expression of EGFR assessment in meningiomas, until date there are no studies from India. Another such marker is p53 which is a tumor suppressor gene located on the short arm of chromosome 17.…”

Section: Introductionmentioning

confidence: 99%

Assessment of expression of epidermal growth factor receptor and p53 in meningiomas

et al. 2014

View full text Add to dashboard Cite

show abstract

The epidermal growth factor receptor is associated with phospholipase C-γ1 in meningiomas

Cited by 48 publications

References 27 publications

Different Activation of Mitogen-Activated Protein Kinase and Akt Signaling Is Associated with Aggressive Phenotype of Human Meningiomas

Different Activation of Mitogen-Activated Protein Kinase and Akt Signaling Is Associated with Aggressive Phenotype of Human Meningiomas

Association between absence of epidermal growth factor receptor immunoreactivity and poor prognosis in patients with atypical meningioma

Assessment of expression of epidermal growth factor receptor and p53 in meningiomas

Contact Info

Product

Resources

About